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One or more keywords matched the following items that are connected to Flaherty, Keith
Item TypeName
Academic Article Antisense therapeutics: lessons from early clinical trials.
Academic Article Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Academic Article Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment.
Academic Article Her-2 targeted therapy: beyond breast cancer and trastuzumab.
Academic Article The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.
Academic Article VEGFR-targeted therapy.
Academic Article HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest.
Academic Article EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
Academic Article Expression of sorafenib targets in melanoma patients treated with carboplatin, paclitaxel and sorafenib.
Academic Article Genetic subgrouping of melanoma reveals new opportunities for targeted therapy.
Academic Article Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification.
Academic Article Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.
Academic Article Resistance to BRAF-targeted therapy in melanoma.
Academic Article Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.
Academic Article An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.
Academic Article Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy.
Academic Article BRAF, a target in melanoma: implications for solid tumor drug development.
Academic Article New molecular targets in melanoma.
Academic Article COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Academic Article CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.
Academic Article The MAPK pathway in melanoma.
Academic Article Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Academic Article Two phase 2 trials of the novel Akt inhibitor perifosine in patients with advanced renal cell carcinoma after progression on vascular endothelial growth factor-targeted therapy.
Academic Article Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.
Academic Article Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.
Academic Article Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.
Academic Article Targeting the RAS pathway in melanoma.
Academic Article Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors.
Academic Article BRAF inhibitors and melanoma.
Academic Article Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.
Academic Article Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation.
Academic Article Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Academic Article Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights.
Academic Article Is it good or bad to find a BRAF mutation?
Academic Article Improved survival with MEK inhibition in BRAF-mutated melanoma.
Academic Article Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.
Academic Article BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.
Academic Article p53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition.
Academic Article BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.
Academic Article Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer.
Academic Article RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
Academic Article CCR drug updates: sorafenib and sunitinib in renal cell carcinoma.
Academic Article Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Academic Article Integrating BRAF/MEK inhibitors into combination therapy for melanoma.
Academic Article MEK and RAF inhibitors for BRAF-mutated cancers.
Academic Article RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.
Academic Article Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.
Academic Article Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Academic Article Hyperspectral imaging: a non-invasive method of imaging melanoma lesions in a patient with stage IV melanoma, being treated with a RAF inhibitor.
Academic Article Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.
Academic Article The future of tyrosine kinase inhibitors: single agent or combination?
Academic Article Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Academic Article Biological challenges of BRAF inhibitor therapy.
Academic Article Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment.
Concept Mitogen-Activated Protein Kinase 3
Concept Mitogen-Activated Protein Kinase Kinases
Concept MAP Kinase Kinase Kinases
Concept Receptor Tyrosine Kinase-like Orphan Receptors
Concept Protein Kinase C-alpha
Concept Cyclin-Dependent Kinase 2
Concept Protein Kinase Inhibitors
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Mitogen-Activated Protein Kinase 1
Concept Janus Kinase 1
Concept MAP Kinase Kinase 2
Concept Glycogen Synthase Kinase 3
Concept Cyclin-Dependent Kinase 6
Concept Cyclin-Dependent Kinase Inhibitor p16
Concept Cyclin-Dependent Kinase Inhibitor p27
Concept Cyclin-Dependent Kinase 4
Concept MAP Kinase Signaling System
Concept Cyclin-Dependent Kinase Inhibitor p18
Concept Protein Kinase C
Concept MAP Kinase Kinase 1
Academic Article MAP kinase signaling and inhibition in melanoma.
Academic Article BRAF in melanoma: current strategies and future directions.
Academic Article TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma.
Academic Article The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling.
Academic Article Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma.
Academic Article Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases.
Academic Article MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition.
Academic Article A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
Academic Article Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.
Academic Article Major therapeutic developments and current challenges in advanced melanoma.
Academic Article Cyclin-dependent kinases as therapeutic targets in melanoma.
Academic Article Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.
Academic Article Genetic alterations and personalized medicine in melanoma: progress and future prospects.
Academic Article Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors.
Academic Article Pathways and therapeutic targets in melanoma.
Academic Article PDGFRa up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
Academic Article A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors.
Academic Article Current status and future directions of molecularly targeted therapies and immunotherapies for melanoma.
Academic Article The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFa.
Academic Article Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma.
Academic Article Combined BRAF (Dabrafenib) and MEK inhibition (Trametinib) in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor.
Academic Article Systematic identification of signaling pathways with potential to confer anticancer drug resistance.
Academic Article Improved overall survival in melanoma with combined dabrafenib and trametinib.
Academic Article Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype.
Academic Article EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma.
Academic Article Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.
Academic Article Survival patterns following brain metastases for patients with melanoma in the MAP-kinase inhibitor era.
Academic Article Effectively targeting CRAF: rational serendipity targeting SRC?
Academic Article The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
Academic Article Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
Academic Article Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma.
Academic Article YAP in MAPK pathway targeted therapy resistance.
Academic Article Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.
Academic Article BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma--A Trial of the ECOG-ACRIN Cancer Research Group (E2804).
Academic Article Feeling energetic? New strategies to prevent metabolic reprogramming in melanoma.
Academic Article Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v): results of a phase 3, open-label, randomised trial.
Academic Article BRAF Inhibition Generates a Host-Tumor Niche that Mediates Therapeutic Escape.
Academic Article Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors.
Academic Article Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.
Academic Article Antitumor Activity of BRAF Inhibitor and IFNa Combination in BRAF-Mutant Melanoma.
Academic Article Survival of patients with advanced metastatic melanoma: The impact of novel therapies.
Academic Article Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells.
Academic Article Correlation of BRAF Mutation Status in Circulating-Free DNA and Tumor and Association with Clinical Outcome across Four BRAFi and MEKi Clinical Trials.
Academic Article Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.
Academic Article Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.
Academic Article The Conundrum of Genetic "Drivers" in Benign Conditions.
Academic Article Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors.
Academic Article Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors.
Academic Article A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors.
Academic Article Subretinal Fluid Associated With MEK Inhibitor Use in the Treatment of Systemic Cancer.
Academic Article Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
Academic Article Parallel In Vivo Assessment of Drug Phenotypes at Various Time Points during Systemic BRAF Inhibition Reveals Tumor Adaptation and Altered Treatment Vulnerabilities.
Academic Article MAPK Pathway Inhibitors Sensitize BRAF-Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB.
Academic Article PLX4032, a highly selective V600EBRAF kinase inhibitor: Clinical correlation of activity with pharmacokinetic and pharmacodynamic parameters in a phase I trial.
Academic Article A phase II trial of perifosine in patients with advanced renal cell carcinoma (RCC) who have failed tyrosine kinase inhibitors (TKI).
Academic Article Pharmacodynamic study of the raf kinase inhibitor BAY 43-9006: Mechanisms of hypertension.
Academic Article Induction of apoptosis by the BRAFV600E kinase inhibitor PLX4032 in BRAFV600E melanoma cells through regulation of endoplasmic reticulum stress-related genes.
Academic Article The BEST trial (E2804): A randomized phase II study of VEGF, RAF kinase, and mTOR combination targeted therapy (CTT) with bevacizumab (bev), sorafenib (sor), and temsirolimus (tem) in advanced renal cell carcinoma (RCC).
Academic Article MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway.
Academic Article Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.
Academic Article Phase I study of GW572016 (lapatinib), a dual kinase inhibitor, in combination with irinotecan (IR), 5-fluorouracil (FU) and leucovorin (LV).
Academic Article PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo.
Academic Article Tissue-Agnostic Drug Development.
Academic Article An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
Academic Article Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials.
Academic Article Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells.
Academic Article A first-in-human phase I, multicenter, open-label, dose-escalation study of the oral RAF/VEGFR-2 inhibitor (RAF265) in locally advanced or metastatic melanoma independent from BRAF mutation status.
Academic Article Survival of patients with advanced metastatic melanoma: the impact of novel therapies-update 2017.
Academic Article BRAF Inhibitors Amplify the Proapoptotic Activity of MEK Inhibitors by Inducing ER Stress in NRAS-Mutant Melanoma.
Academic Article Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study.
Academic Article Tumor-associated B-cells induce tumor heterogeneity and therapy resistance.
Academic Article PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.
Academic Article First-in-human trial of the PI3Kß-selective inhibitor SAR260301 in patients with advanced solid tumors.
Academic Article Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.
Academic Article First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study.
Academic Article Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.
Academic Article Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.
Academic Article Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
Academic Article Toward Minimal Residual Disease-Directed Therapy in Melanoma.
Academic Article Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS): a multicentre, open-label, randomised, phase 3 trial.
Academic Article A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITFhigh /AXLlow melanoma.
Academic Article A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.
Academic Article ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.
Academic Article MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.
Academic Article A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations.
Academic Article Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma.
Academic Article Genetic Aberrations in the CDK4 Pathway Are Associated with Innate Resistance to PD-1 Blockade in Chinese Patients with Non-Cutaneous Melanoma.
Academic Article A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors.
Academic Article Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.
Academic Article Angiogenic Factor and Cytokine Analysis among Patients Treated with Adjuvant VEGFR TKIs in Resected Renal Cell Carcinoma.
Academic Article Impact of depth of response on survival in patients treated with cobimetinib?±?vemurafenib: pooled analysis of BRIM-2, BRIM-3, BRIM-7 and coBRIM.
Academic Article Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation.
Academic Article Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131).
Academic Article Survival of patients with advanced metastatic melanoma: The impact of MAP kinase pathway inhibition and immune checkpoint inhibition - Update 2019.
Academic Article Targeted and immunotherapies in BRAF mutant melanoma: where we stand and what to expect.
Academic Article Dabrafenib and Trametinib in Patients With Tumors With BRAFV600E Mutations: Results of the NCI-MATCH Trial Subprotocol H.
Academic Article Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.
Academic Article Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma: safety run-in and biomarker cohorts of COMBI-i.
Academic Article Correction to: MAP kinase signaling and inhibition in melanoma.
Academic Article Efficacy and Safety of Trametinib in Non-V600 BRAF Mutant Melanoma: A Phase II Study.
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  • Elongation Factor 2 Kinase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.