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One or more keywords matched the following items that are connected to Yaffe, Michael
Item TypeName
Academic Article MAGUK SH3 domains--swapped and stranded by their kinases?
Academic Article The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function.
Academic Article A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase.
Academic Article A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.
Academic Article Distinct mechanisms act in concert to mediate cell cycle arrest.
Academic Article Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1.
Academic Article Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis.
Academic Article Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.
Academic Article Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase.
Academic Article Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation.
Academic Article Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Academic Article Studying the optimal peptide substrate motifs of protein kinase C using oriented peptide libraries.
Academic Article Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation.
Academic Article Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.
Academic Article Study of substrate specificity of MAPKs using oriented peptide libraries.
Academic Article MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
Academic Article The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Academic Article The combined status of ATM and p53 link tumor development with therapeutic response.
Academic Article Signal transduction. Grabbing phosphoproteins.
Academic Article Signal transduction: molecular monogamy.
Academic Article A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.
Academic Article Functional dynamics of Polo-like kinase 1 at the centrosome.
Academic Article The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.
Academic Article Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening.
Academic Article A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
Academic Article Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.
Academic Article A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
Academic Article Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody.
Academic Article Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
Academic Article How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis.
Academic Article p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
Academic Article Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
Academic Article The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry.
Academic Article Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase.
Academic Article Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Academic Article 14-3-3 Proteins--a focus on cancer and human disease.
Academic Article MAP kinase pathways activated by stress: the p38 MAPK pathway.
Academic Article A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis.
Academic Article ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.
Academic Article Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.
Academic Article Systematic discovery of in vivo phosphorylation networks.
Concept Mitogen-Activated Protein Kinase 3
Concept Mitogen-Activated Protein Kinase Kinases
Concept Protein Kinase Inhibitors
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Mitogen-Activated Protein Kinase 1
Concept CDC2 Protein Kinase
Concept Mitogen-Activated Protein Kinase 8
Concept Glycogen Synthase Kinase 3
Concept A Kinase Anchor Proteins
Concept Nucleoside-Phosphate Kinase
Concept I-kappa B Kinase
Concept Cyclin-Dependent Kinase 6
Concept Casein Kinase II
Concept Protein Kinase C-delta
Concept ZAP-70 Protein-Tyrosine Kinase
Concept Cyclin-Dependent Kinase Inhibitor p16
Concept Cyclin-Dependent Kinase Inhibitor p27
Concept Cyclin-Dependent Kinase 4
Concept MAP Kinase Signaling System
Concept Protein Kinase C
Concept DNA-Activated Protein Kinase
Concept Pyruvate Kinase
Academic Article Cell cycle re-entry mechanisms after DNA damage checkpoints: giving it some gas to shut off the breaks!
Academic Article Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.
Academic Article Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
Academic Article Screening kinase phosphorylation motifs using Peptide libraries.
Academic Article Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.
Academic Article Fixin' to divide.
Academic Article Salvaging the septic heart through targeting the interleukin-6/p38 mitogen-activated protein kinase signaling network.
Academic Article DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
Academic Article Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.
Academic Article Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.
Academic Article Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
Academic Article Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks.
Academic Article Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.
Academic Article Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.
Academic Article Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs.
Academic Article Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Academic Article Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.
Academic Article A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Grant Neutrophil Priming in Trauma and Sepsis
Grant High-Throughput Assay Design:Polo Kinase Inhibitors(RMI)
Grant 2004 Growth Factor Signalling Gordon Conference
Grant Identification of Molecular Pathways in Cancer Biology
Grant Phosphoserine Dependant Assembly of Signaling complexes
Grant HEAT SHOCK PROTEIN HSP-90 FOLLOWING INJURY
Grant Modeling human phosphorylation networks through kinome-wide profiling
Grant Protein Kinase Signaling and Cell Cycle Control
Grant Protein Kinase Signaling in the Genotoxic Stress Response
Academic Article Histidine N(t)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
Academic Article Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.
Grant RNA-Binding Proteins as Molecular Integrators that Control the Response of HGSOC to Ant-Cancer Therapies
Academic Article Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.
Academic Article Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.
Academic Article Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
Academic Article Substrate-based kinase activity inference identifies MK2 as driver of colitis.
Academic Article Redox priming promotes Aurora A activation during mitosis.
Academic Article BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.
Academic Article Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division.
Academic Article MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.
Academic Article Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.
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  • Elongation Factor 2 Kinase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.