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overview Faculty Academic Appointments 12/92-11/93 Instructor Department of Physiology UTHSCSA 12/93-12/96 Assistant Professor Department of Physiology UTHSCSA 06/97-05/04 Assistant Professor Department of Biochemistry Weill Medical College of Cornell University, New York, NY 10/98-06/06 Assistant Professor Department of Neuroscience Weill Medical College of Cornell University 07/04-04/07 Associate Professor Department of Neuroscience Weill Medical College of Cornell University 01/08 - 9/16 Associate Professor Department of Surgery Harvard Medical School; Split to newly created Department of Neurosurgery (11/2013) 10/16 -- present Associate Professor Department of Medicine Harvard Medical School Appointments at Hospitals/Affiliated Institutions 12/96-04/07 Research Scientist Dementia Research Service Burke Medical Research Institute 04/07-12/06 Lead Investigator Department of Neurosurgery Brigham and Women’s Hospital 01/16 - Lead Investigator-Biochemist Division of Sleep and Circadian Disorders Brigham and Women’s Hospital Professional Societies American Association for Advancement of Science (AAAS) American Cancer Society American Chemical Society (ACS) American Society for Biochemistry and Molecular Biology (ASBMB) American Society for Nutrition Sleep Research Society Issued US patents Biomarkers for health effects of low calorie diets Kristal, B.S., W.R. Matson, P.E. Milbury, Methodology for predicting and/or diagnosing disease, US Patent 6,558,955, issued 5/6/2003 Identification of biomarkers of caloric restriction as potential markers for human disease risk using a Coularray-based (electrochemistry) approach Metabolomics Patent Family, 10 Issued US Patents, Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics. This patent family was originally licensed from our lab by Metabolon from Weill Medical College of Cornell University. Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,005,255, issued 2/28/2006 Describes a method for identifying small molecules relevant for ALS, i.e., this is the primary patent for the use of metabolomics for studies related to ALS. Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,329,489, issued 2/12/2008 Describes a method for identifying small molecules relevant for ALS, schizophrenia, depression, Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease, i.e., this is the primary patent for the use of metabolomics for the major neurological diseases Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,550,258, issued 6/23/2009 This is the primary patent for the use of metabolomics for most neurological diseases and conditions not specifically covered above. Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,550,260, issued 6/23/2009 This is the primary patent for the use of metabolomics for most metabolic diseases including diabetes, obesity, cachexia, and anorexia. Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,553,616, issued 6/30/2009 This is the primary patent for the use of metabolomics for most oncologic diseases (cancer) Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,635,556, issued 12/22/2009 This is the primary patent for the use of metabolomics to address the effects of added agents (e.g., drugs, therapeutics) in patients suffering metabolic, immunologic, neurologic, oncologic, diseases, viral infections, and other diseases, i.e., this is the primary patent for the use of metabolomics for issues related to drug development or drug treatments Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,682,783, issued 3/23/2010 This patent furthers the description of the use of metabolomics in depression . Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,682,784, issued 3/23/2010 This patent furthers the description of the use of metabolomics in schizophrenia. Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,910,301, issued 3/22/2011 This patent furthers the description of the use of metabolomics in studying the effects of exogenous agents, including the use of metabolomics for studying/determining toxicity and known and unknown toxins. Kaddurah-Daouk, R., and Kristal, B.S., Methods for drug discovery, disease treatment, and diagnosis using metabolomics, US Patent 7,947,453, issued 5/24/2011 This patent covers the use of metabolomics for the primary prediction of the effect of a drug on an individual. Machine Learning Patent Family, two issued patents, Kristal, B.S. and Martin R.J., System and method to enable training a machine learning network in the presence of weak or absent training exemplars This patent family enables the combining of human and machine intelligence for solving problems in which the users lack the typically required large datasets. The two patents differ in technical aspects of how the modeling can be done. Kristal, B.S. and Martin R.J., System and method to enable training a machine learning network in the presence of weak or absent training exemplars, US Patent 8,095,480, issued 1/10/2012 Kristal, B.S. and Martin R.J., System and method to enable training a machine learning network in the presence of weak or absent training exemplars, US Patent 8,838,511, issued 9/16/2014 Trainees Junior Faculty Co-mentor, Katherine Gregory, K23 Award, (note: Boston College Faculty at the time of K-award, now Harvard Medical school Faculty) Post-Doctoral Fellows Honglian Shi, PhD, Boris F. Krasnikov, PhD, Ugo Paolucci, MD, Irina Stavrovskaya, PhD (also mentored as HMS Instructor) Sergei Baranov, PhD Xiaofeng (Sophie) Guo, PhD Susan Bird (née Schaivo), PhD (also mentored as HMS Instructor) Rose Gathungu, PhD (also mentored as HMS Instructor) Fateme Tousi, PhD Shucha Zhang, PhD Marlen Menlyadiev, PhD (Current) Harvard College Undergraduates Defne Altan, research and advisor for her honors undergraduate thesis (Thomas T Hoopes Prize) Research Interests My lab’s primary projects relate to the use of metabolomics and lipidomics for personalized risk analysis for future chronic/age-related diseases based on diet (quantity and quality), adiposity and other “lifestyle” factors such as sleep and circadian phenotypes. We seek to work across disciplines, resolving issues at the levels of analytical chemistry and informatics as well as in the biological and clinical realms. I served as the founding secretary and member of the Board of Directors of the Metabolomics Society (2004-2008) and on their Board of Directors (2004-2011).
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  • Caloric Restriction
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.