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One or more keywords matched the following properties of Pascual-Leone, Alvaro
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overview At the Berenson-Allen Center for Noninvasive Brain Stimulation that I direct we have three distinct missions: (1) Research explores brain-behavior relations, brain plasticity and its modulation, employing different noninvasive brain stimulation techniques combined with careful task design, electroencephalography, and functional brain imaging. (2) Educational efforts feature an intensive course in noninvasive brain stimulation offered three times per year as part of Harvard’s Continuing Medical Education program. (3) Clinical work includes diagnostic studies therapeutic applications of noninvasive brain stimulation for treatment of neuropsychiatric disorders. My work has been fundamental in establishing transcranial magnetic stimulation (TMS) as a tool capable of revealing causal brain-behavior relations and the timing of information flow and dynamic adaptation in neural networks. My laboratory has contributed to increasing the knowledge about the mechanisms of action and improving the methodology of TMS and its combination with other neurophysiologic and brain imaging methods. For example we developed a method to interface TMS with EEG to allow the study of the effects of brain stimulation on ongoing brain activity and ultimately enable the use of EEG activity as a means of controlling the stimulation applied, and a novel methodology to introduce TMS into the MRI scanner in order to be able to study the neural activity evoked by TMS and thus correlate behavioral with underlying neurophysiologic effects. I was the first to show that trains of repetitive TMS can be reliably and safely disrupt the activity of a given brain region transiently and thus provide insights about the causality of brain activity in behavior. I demonstrated the rapid plasticity of motor cortical outputs during motor learning, the requirement of visual cortex input for tactile Braille reading in the blind, the causal role of primary visual cortex and the dynamics of interhemipheric compensatory processes during mental imagery, and the need for fast back-projections in visual awareness tasks. Moreover, coupling TMS with physiologic and imaging techniques, I showed that repetitive TMS can induce lasting changes in regional brain excitability and exert trans-synaptic modulatory effects on neural network activity in animal and human studies. This allows for the investigation of the rapid neuroplastic changes that compensate for brain injury or dysfunction, and permits the model-driven, individually-tailored modulation of disrupted networks for treating common neuropsychiatric conditions. We showed that TMS can aide in the recovery of hand function and aphasia after stroke, the adaptation to blindness, the rehabilitation of neglect, the control of addictive behavior, and the acquisition of language and imitation behavior in autism. My laboratory carried out the first double blind study of rTMS in major depression, and the first proof-of-principle studies suggesting therapeutic possibilities of TMS in epilepsy, Parkinson's disease, visceral pain and dystonia. This work provides support to the notion that modulation of activity along a distributed neural network can induce long-lasting plastic changes, even in the adult brain, and have behavioral consequences, which in certain conditions may be therapeutic.
One or more keywords matched the following items that are connected to Pascual-Leone, Alvaro
Item TypeName
Academic Article Transcranial magnetic stimulation (TMS)
Academic Article Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study.
Academic Article A new device and protocol for combining TMS and online recordings of EEG and evoked potentials.
Academic Article Single pulse TMS-induced modulations of resting brain neurodynamics encoded in EEG phase.
Academic Article Inter- and intra-individual variability of paired-pulse curves with transcranial magnetic stimulation (TMS).
Academic Article Repetitive TMS temporarily alters brain diffusion.
Academic Article Impact of TMS on the primary motor cortex and associated spinal systems.
Academic Article Reversal of TMS-induced motor twitch by training is associated with a reduction in excitability of the antagonist muscle.
Academic Article Integrating TMS with EEG: How and what for?
Academic Article Exploring paradoxical functional facilitation with TMS.
Academic Article A review of combined TMS-EEG studies to characterize lasting effects of repetitive TMS and assess their usefulness in cognitive and clinical neuroscience.
Academic Article Visual cortex excitability increases during visual mental imagery--a TMS study in healthy human subjects.
Academic Article Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson's disease and concurrent depression.
Academic Article EEG onset of a seizure during TMS from a focus independent of the stimulation site.
Academic Article Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS.
Academic Article Screening questionnaire before TMS: an update.
Academic Article Current use of ECT and TMS
Academic Article Baseline cortical excitability determines whether TMS disrupts or facilitates behavior.
Academic Article Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity.
Academic Article Cumulative sessions of repetitive transcranial magnetic stimulation (rTMS) build up facilitation to subsequent TMS-mediated behavioural disruptions.
Academic Article Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI.
Academic Article Effects of single-pulse transcranial magnetic stimulation (TMS) on functional brain activity: a combined event-related TMS and evoked potential study.
Academic Article Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements.
Academic Article La TMS pour experimenter sur le cerveau sans danger
Academic Article Studies of crossmodal functions with TMS
Academic Article TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia.
Academic Article TMS
Academic Article Improved naming after TMS treatments in a chronic, global aphasia patient--case report.
Academic Article State-dependency effects on TMS: a look at motive phosphene behavior.
Academic Article The NeuroStar TMS device: conducting the FDA approved protocol for treatment of depression.
Academic Article Insights on the neural basis of motor plasticity induced by theta burst stimulation from TMS-EEG.
Academic Article Improved language in a chronic nonfluent aphasia patient after treatment with CPAP and TMS.
Academic Article TMS: using the theta-burst protocol to explore mechanism of plasticity in individuals with Fragile X syndrome and autism.
Academic Article Measuring and manipulating brain connectivity with resting state functional connectivity magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS).
Academic Article “Transcranial Magnetic Stimulation (TMS) Methods and Apparatus”
Academic Article Transcranial magnetic stimulation (TMS)
Academic Article Repetitive TMS over posterior STS disrupts perception of biological motion.
Academic Article Cerebellar TMS in treatment of a patient with cerebellar ataxia: evidence from clinical, biomechanics and neurophysiological assessments.
Academic Article The EEG correlates of the TMS-induced EMG silent period in humans.
Mentoring - Completed Student Project EEG microstates and repetitive TMS: Changes in EEG microstate dynamics following continuous theta burst stimulation to the dorsolateral prefrontal cortex
Academic Article Differentiation of motor cortical representation of hand muscles by navigated mapping of optimal TMS current directions in healthy subjects.
Academic Article TMS affects moral judgment, showing the role of DLPFC and TPJ in cognitive and emotional processing.
Academic Article Differential effects of motor cortical excitability and plasticity in young and old individuals: a Transcranial Magnetic Stimulation (TMS) study.
Academic Article Language improvements after TMS plus modified CILT: Pilot, open-protocol study with two, chronic nonfluent aphasia cases.
Academic Article Transcranial magnetic stimulation (TMS) therapy for autism: an international consensus conference held in conjunction with the international meeting for autism research on May 13th and 14th, 2014.
Academic Article Synchronous and opposite roles of the parietal and prefrontal cortices in bistable perception: a double-coil TMS-EEG study.
Academic Article Cortical Excitability During Passive Action Observation in Hospitalized Adults With Subacute Moderate to Severe Traumatic Brain Injury: A Preliminary TMS Study.
Academic Article The Clinical TMS Society Consensus Review and Treatment Recommendations for TMS Therapy for Major Depressive Disorder.
Grant Neural Plasticity Associated with Braille Learning
Grant Cortical plasticity in type II diabetes mellitus
Grant Transcranial Stimulation in Spino-Cerebellar Ataxia
Grant Role of functional brain connectivity on efficacy of TMS for depression
Grant Seeing through the Ears
Grant Cortical Plasticity in Autism Spectrum Disorders
Grant Study and Modulation of Brain Plasticity
Academic Article Consensus: "Can tDCS and TMS enhance motor learning and memory formation?"
Academic Article Multifocal repetitive TMS for motor and mood symptoms of Parkinson disease: A randomized trial.
Academic Article Preliminary Upper Estimate of Peak Currents in Transcranial Magnetic Stimulation at Distant Locations From a TMS Coil.
Academic Article Reproducibility of Single-Pulse, Paired-Pulse, and Intermittent Theta-Burst TMS Measures in Healthy Aging, Type-2 Diabetes, and Alzheimer's Disease.
Academic Article Rostral anterior cingulate cortex is a structural correlate of repetitive TMS treatment response in depression.
Grant Reliability of Repetitive TMS-induced Modulation of Cortical Excitability
Grant The Development and Human Translation of Temporal Interference Brain Stimulation
Academic Article Clinical utility and prospective of TMS-EEG.
Academic Article Effects of Transcranial Static Magnetic Stimulation on Motor Cortex Evaluated by Different TMS Waveforms and Current Directions.
Academic Article Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's disease.
Academic Article Ultra-focal Magnetic Stimulation Using a µTMS coil: a Computational Study.
Academic Article Large-scale analysis of interindividual variability in theta-burst stimulation data: Results from the 'Big TMS Data Collaboration'.
Academic Article Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.
Academic Article Large-scale analysis of interindividual variability in single and paired-pulse TMS data.
Search Criteria
  • TMS
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.