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One or more keywords matched the following properties of Pascual-Leone, Alvaro
overview At the Berenson-Allen Center for Noninvasive Brain Stimulation that I direct we have three distinct missions: (1) Research explores brain-behavior relations, brain plasticity and its modulation, employing different noninvasive brain stimulation techniques combined with careful task design, electroencephalography, and functional brain imaging. (2) Educational efforts feature an intensive course in noninvasive brain stimulation offered three times per year as part of Harvard’s Continuing Medical Education program. (3) Clinical work includes diagnostic studies therapeutic applications of noninvasive brain stimulation for treatment of neuropsychiatric disorders. My work has been fundamental in establishing transcranial magnetic stimulation (TMS) as a tool capable of revealing causal brain-behavior relations and the timing of information flow and dynamic adaptation in neural networks. My laboratory has contributed to increasing the knowledge about the mechanisms of action and improving the methodology of TMS and its combination with other neurophysiologic and brain imaging methods. For example we developed a method to interface TMS with EEG to allow the study of the effects of brain stimulation on ongoing brain activity and ultimately enable the use of EEG activity as a means of controlling the stimulation applied, and a novel methodology to introduce TMS into the MRI scanner in order to be able to study the neural activity evoked by TMS and thus correlate behavioral with underlying neurophysiologic effects. I was the first to show that trains of repetitive TMS can be reliably and safely disrupt the activity of a given brain region transiently and thus provide insights about the causality of brain activity in behavior. I demonstrated the rapid plasticity of motor cortical outputs during motor learning, the requirement of visual cortex input for tactile Braille reading in the blind, the causal role of primary visual cortex and the dynamics of interhemipheric compensatory processes during mental imagery, and the need for fast back-projections in visual awareness tasks. Moreover, coupling TMS with physiologic and imaging techniques, I showed that repetitive TMS can induce lasting changes in regional brain excitability and exert trans-synaptic modulatory effects on neural network activity in animal and human studies. This allows for the investigation of the rapid neuroplastic changes that compensate for brain injury or dysfunction, and permits the model-driven, individually-tailored modulation of disrupted networks for treating common neuropsychiatric conditions. We showed that TMS can aide in the recovery of hand function and aphasia after stroke, the adaptation to blindness, the rehabilitation of neglect, the control of addictive behavior, and the acquisition of language and imitation behavior in autism. My laboratory carried out the first double blind study of rTMS in major depression, and the first proof-of-principle studies suggesting therapeutic possibilities of TMS in epilepsy, Parkinson's disease, visceral pain and dystonia. This work provides support to the notion that modulation of activity along a distributed neural network can induce long-lasting plastic changes, even in the adult brain, and have behavioral consequences, which in certain conditions may be therapeutic.
One or more keywords matched the following items that are connected to Pascual-Leone, Alvaro
Item TypeName
Mentoring - Completed Student Project Modulation of the dorsolateral prefrontal cortex with repetitive transcranial magnetic stimulation in obesity.
Academic Article Modulation of spinal cord excitability by subthreshold repetitive transcranial magnetic stimulation of the primary motor cortex in humans.
Academic Article Transcranial magnetic stimulation evidence of a potential role for progesterone in the modulation of premenstrual corticocortical inhibition in a woman with catamenial seizure exacerbation.
Academic Article Study and modulation of human cortical excitability with transcranial magnetic stimulation.
Academic Article Single pulse TMS-induced modulations of resting brain neurodynamics encoded in EEG phase.
Academic Article Modulation in motor threshold after a severe episode of gastrointestinal distress.
Academic Article Effects of musical training on speech-induced modulation in corticospinal excitability.
Academic Article Modulation of right motor cortex excitability without awareness following presentation of masked self-images.
Academic Article Modulation of intracortical neuronal circuits in human hand motor area by digit stimulation.
Academic Article The role of the angular gyrus in the modulation of visuospatial attention by the mental number line.
Academic Article Modulation of motor cortical outputs to the reading hand of braille readers.
Academic Article Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation.
Academic Article Modulation of cortical motor outputs by the symbolic meaning of visual stimuli.
Academic Article Phase-specific modulation of cortical motor output during movement observation.
Academic Article Assessment and modulation of neural plasticity in rehabilitation with transcranial magnetic stimulation.
Academic Article Abnormal modulation of corticospinal excitability in adults with Asperger's syndrome.
Academic Article Modulation of a brain-behavior relationship in verbal working memory by rTMS.
Academic Article Modulation of untruthful responses with non-invasive brain stimulation.
Academic Article Modulation of premotor mirror neuron activity during observation of unpredictable grasping movements.
Academic Article Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI.
Academic Article Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus.
Academic Article Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: a double-blind, sham-controlled study.
Academic Article The role of reading activity on the modulation of motor cortical outputs to the reading hand in Braille readers.
Academic Article Modulation of cortical motor output maps during development of implicit and explicit knowledge.
Academic Article Reciprocal modulation and attenuation in the prefrontal cortex: an fMRI study on emotional-cognitive interaction.
Academic Article Modulation of steady-state auditory evoked potentials by cerebellar rTMS.
Academic Article Rapid reversible modulation of human motor outputs after transient deafferentation of the forearm: a study with transcranial magnetic stimulation.
Academic Article Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC).
Academic Article Modulation of decision-making in a gambling task in older adults with transcranial direct current stimulation.
Academic Article Interhemispheric modulation induced by cortical stimulation and motor training.
Academic Article Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson's disease.
Academic Article Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills.
Academic Article Rapid modulation of human cortical motor outputs following ischaemic nerve block.
Academic Article Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy.
Academic Article Exploration and modulation of brain network interactions with noninvasive brain stimulation in combination with neuroimaging.
Academic Article Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation.
Academic Article Modulation of input-output curves by low and high frequency repetitive transcranial magnetic stimulation of the motor cortex.
Academic Article Unconscious modulation of motor cortex excitability revealed with transcranial magnetic stimulation.
Academic Article Modulation of EEG functional connectivity networks in subjects undergoing repetitive transcranial magnetic stimulation.
Academic Article Modulation of smoking and decision-making behaviors with transcranial direct current stimulation in tobacco smokers: a preliminary study.
Academic Article Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder.
Academic Article Neurochemical Modulation in Posteromedial Default-mode Network Cortex Induced by Transcranial Magnetic Stimulation.
Academic Article Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders.
Grant Cortical plasticity in type II diabetes mellitus
Grant Cortical Plasticity in Autism Spectrum Disorders
Grant Study and Modulation of Brain Plasticity
Grant Non-invasive stimulation for improving motor function in spinal cord injury
Academic Article Modulation of motor cortex excitability predicts antidepressant response to prefrontal cortex repetitive transcranial magnetic stimulation.
Grant Reliability of Repetitive TMS-induced Modulation of Cortical Excitability
Academic Article Modulation of network-to-network connectivity via spike-timing-dependent noninvasive brain stimulation.
Academic Article Drug-Responsive Inhomogeneous Cortical Modulation by Direct Current Stimulation.
Academic Article Modulation of motor cortical excitability by continuous theta-burst stimulation in adults with autism spectrum disorder.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.