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Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells.
Methylmercury-induced toxicity is mediated by enhanced intracellular calcium through activation of phosphatidylcholine-specific phospholipase C.
Nuclear translocation of cytosolic phospholipase A2 is induced by ATP depletion.
Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells.
Vasopressin increases cytosolic free calcium concentration in glomerular mesangial cells.
Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.