Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Nahrendorf, Matthias
PropertyValue
overview The Nahrendorf laboratory focuses on the role of immunity in cardiovascular health and disease, specifically in atherosclerosis and heart failure. Of particular interest are the function, supply and production of leukocytes, and the signals that regulate hematopoiesis after injuries such as myocardial infarction or stroke. We described that after MI, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart (Science 2009, New York Times 2009). We further found that MI, chronic stress and sedentary life style modulate the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells (Nature 2012, Nature Med 2014, Nature Med 2019). Resident macrophages, on the other hand, do not derive from circulating cells and promote steady state functions such as cardiac conduction (Cell 2017). The laboratory also develops and employs imaging to sample biology non-invasively, using MR, nuclear, optical and microscopic modalities.
One or more keywords matched the following items that are connected to Nahrendorf, Matthias
Item TypeName
Academic Article Origins of tumor-associated macrophages and neutrophils.
Academic Article Angiotensin II drives the production of tumor-promoting macrophages.
Academic Article Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
Academic Article Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
Academic Article Myocardial infarction accelerates atherosclerosis.
Academic Article Innate response activator B cells protect against microbial sepsis.
Academic Article Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction.
Concept Spleen
Academic Article Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir.
Academic Article Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans.
Academic Article Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.
Academic Article Lifestyle effects on hematopoiesis and atherosclerosis.
Academic Article Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.
Academic Article Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?
Academic Article Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation.
Academic Article On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.
Academic Article E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction.
Academic Article A durable murine model of spleen transplantation with arterial and venous anastomoses.
Search Criteria
  • Spleen
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.