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One or more keywords matched the following properties of Guttmann, Charles
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overview Dr. Charles R. G. Guttmann is an Associate Professor of Radiology at Harvard Medical School, and the Director of the Center for Neurological Imaging, a multi-disciplinary laboratory at Brigham and Women’s Hospital, combining biomedical and computer scientists/biomedical engineers. His research interests focus on the understanding, modeling, and monitoring of neurological diseases, such as multiple sclerosis (MS) and small vessel disease in aging, by integrating imaging-derived biomarkers with clinical, genetic, immunological, and other biomarkers. To this end his laboratory has developed a large scale repository and image analysis workflow management system that has been in use for close to 20 years, and has been populated with images, image-derived metrics, a variety of genetic and blood biomarkers, as well as clinical information inserted at the time of clinical visits. To date the data repository includes over 25,000 magnetic resonance imaging (MRI) exams and data from over 45,000 clinical visits over the past in 8,556 MS patients. This system has enabled multiple large-scale, cross-disciplinary studies addressing a variety of scientific questions, such as genetic determinants of brain atrophy in MS, association studies between risk factors such as smoking and the progression of disease in MS, as well as prospective longitudinal studies to understand the clinical evolution and pathogenesis of MS, as well as to generate predictive models for use in clinical disease management. His current work includes identifying MRI correlates of fatigue and predictors of response to fatigue management interventions. Other projects in Dr. Guttmann's laboratory include studies on the role of perivascular spaces in sleep, sleep deprivation Alzheimer's Disease, and other neurological conditions; lesion-symptom mapping for image-guided focused ultrasound treatment of essential tremor. Dr. Guttmann is also leading the development of SPINE, a web-based virtual laboratory for collaborative scientific research and education. SPINE integrates data federation, image analysis workflows (automated and interactive), as well as statistical modeling. A differentiating aspect of SPINE is the tight interaction between scientific experimentation on one side, and education and image analysis standardization on the other. This approach includes web-based “club-sourcing” of domain experts and ‘crowdsourcing’ of less educated scientific contributors that can be certified in focused analytical tasks, such as outlining an anatomical structure on a CT or MRI image stack.
One or more keywords matched the following items that are connected to Guttmann, Charles
Item TypeName
Academic Article Automatic identification of gray matter structures from MRI to improve the segmentation of white matter lesions.
Academic Article A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis.
Academic Article Multiple sclerosis medical image analysis and information management.
Academic Article MRI time series modeling of MS lesion development.
Academic Article Quantitative follow-up of patients with multiple sclerosis using MRI: technical aspects.
Academic Article Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis.
Academic Article Simplified MRI prediction of clinically definite multiple sclerosis: a stepping stone towards treatment criteria?
Academic Article CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.
Academic Article Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed?
Academic Article Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis.
Academic Article Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy.
Academic Article Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study.
Academic Article Analysis of individual changes of multiple sclerosis lesions’ 3-D geometry over time using spherical harmonics
Academic Article MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability.
Academic Article Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage.
Academic Article Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis.
Academic Article Application of spherical harmonics derived space rotation invariant indices to the analysis of multiple sclerosis lesions' geometry by MRI.
Academic Article Thalamic atrophy and cognition in multiple sclerosis.
Academic Article Three-dimensional analysis of the geometry of individual multiple sclerosis lesions: detection of shape changes over time using spherical harmonics.
Academic Article Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis.
Academic Article Single-slab three-dimensional T2-weighted fast spin-echo MR imaging of multiple sclerosis patients
Academic Article Magnetic resonance imaging and multiple sclerosis: what does it tell us?
Academic Article Synergies of High-Resolution Multi-Channel Lesion Segmentation in multiple Sclerosis: MPRAGE, 3D FLAIR, 3D T2WI and 3D DIR
Academic Article A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis.
Academic Article Can MRI reveal phenotypes of multiple sclerosis?
Academic Article Rate of brain atrophy in benign vs early multiple sclerosis.
Academic Article One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosis.
Academic Article Automated segmentation of multiple sclerosis lesion subtypes with multichannel MRI.
Academic Article Time-series modeling of multiple sclerosis disease activity: a promising window on disease progression and repair potential?
Academic Article The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis.
Academic Article A method for the analysis of the geometrical relationship between white matter pathology and the vascular architecture of the brain.
Academic Article Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosis.
Academic Article Registration and subtraction of 2D-T2SE images in a routine multicentre multiple sclerosis (MS) trial setting
Academic Article Time-series analysis of MRI intensity patterns in multiple sclerosis.
Academic Article Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study.
Academic Article Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis.
Academic Article A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis.
Academic Article Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability.
Academic Article Building a probabilistic anatomical brain atlas for multiple sclerosis
Academic Article "Now, more than ever. Progress in multiple sclerosis research"
Academic Article Predicting short-term disability in multiple sclerosis.
Academic Article Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis.
Academic Article HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study.
Academic Article Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale.
Academic Article Subtraction MR images in a multiple sclerosis multicenter clinical trial setting.
Academic Article Long-interval T2-weighted subtraction magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials.
Academic Article Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis.
Academic Article Identification of abnormal brain configurations in multiple sclerosis
Academic Article Registration and subtraction of 2D-T2SE images in a routine multi-centre multiple sclerosis trial setting
Academic Article A prospective study of multiple sclerosis: correlation between MRI, clinical and immunological findings
Academic Article Incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study.
Academic Article Identification and clinical impact of multiple sclerosis cortical lesions as assessed by routine 3T MR imaging.
Academic Article Segmentation of subtraction images for the measurement of lesion change in multiple sclerosis.
Academic Article Segmentation of multiple lesion types in multiple sclerosis
Academic Article MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals.
Academic Article Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters.
Academic Article A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon beta
Academic Article Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis.
Academic Article Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy.
Academic Article Unbiased treatment effect estimates by modeling the disease process of multiple sclerosis.
Academic Article Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Gadolinium MRI Meta-analysis Group.
Academic Article A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.
Academic Article 3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis.
Academic Article Human gray matter: feasibility of single-slab 3D double inversion-recovery high-spatial-resolution MR imaging.
Academic Article MRI in multiple sclerosis: current status and future prospects.
Academic Article Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study.
Academic Article MRI time-series modeling of acute and subacute phases of multiple sclerosis lesions
Academic Article Magnetic Resonance Disease Severity Scale (MRDSS) Predicts Clinical Progression in Multiple Sclerosis
Academic Article Prevalence and pattern of cognitive impairment in early MS
Academic Article Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression
Academic Article Quantitative dynamic analysis of the evolution of multiple sclerosis lesions using optical field flow computation of serial MRI data
Academic Article Image registration framework for large-scale longitudinal MRI data sets: strategy and validation.
Academic Article The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis.
Academic Article Monitoring multiple sclerosis: requirements for image segmentation
Academic Article The evolution of multiple sclerosis lesions on serial MR.
Academic Article Smoking and disease progression in multiple sclerosis.
Academic Article Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data.
Academic Article Seasonal prevalence of MS disease activity.
Academic Article Daclizumab use in patients with pediatric multiple sclerosis.
Academic Article Highly reproducible MS lesion burden quantitation
Academic Article Disease modeling in multiple sclerosis: assessment and quantification of sources of variability in brain parenchymal fraction measurements.
Academic Article A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.
Academic Article The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis.
Academic Article HLA B*44: protective effects in MS susceptibility and MRI outcome measures.
Academic Article MRI Meausurement of Whole Spinal Cord Volume at 3T: Reproducibility and Relevance to Multiple Sclerosis
Academic Article Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis.
Academic Article Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden.
Academic Article Quantitative follow-up of patients with multiple sclerosis using MRI: reproducibility.
Academic Article Analysis of geometrical relations between multiple sclerosis lesions and brain vasculature
Academic Article Variability of brain atrophy estimates in multiple sclerosis
Academic Article Application of single-slab 3D-FLAIR, 3D-DIR and 3D-T2
Academic Article MRI Measures of Pathology and their Relationship to Central Nervous System Atrophy in Multiple Sclerosis
Academic Article Integration of contrast-enhanced and native MR imaging in multiple sclerosis
Concept Multiple Sclerosis
Concept Multiple Sclerosis, Chronic Progressive
Concept Multiple Sclerosis, Relapsing-Remitting
Academic Article No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50.
Academic Article Interferon beta 1b following natalizumab discontinuation: one year, randomized, prospective, pilot trial.
Academic Article Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome.
Academic Article Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.
Academic Article Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study.
Academic Article An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2.
Academic Article Microstructural changes in the striatum and their impact on motor and neuropsychological performance in patients with multiple sclerosis.
Academic Article Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study.
Academic Article Weekly multimodal MRI follow-up of two multiple sclerosis active lesions presenting a transient decrease in ADC.
Academic Article Using multiple imputation to efficiently correct cerebral MRI whole brain lesion and atrophy data in patients with multiple sclerosis.
Academic Article Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models.
Academic Article Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients.
Academic Article Multiple sclerosis lesion formation and early evolution revisited: A weekly high-resolution magnetic resonance imaging study.
Academic Article A Sensitive and Automatic White Matter Fiber Tracts Model for Longitudinal Analysis of Diffusion Tensor Images in Multiple Sclerosis.
Academic Article Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression.
Academic Article Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis.
Academic Article Hippocampal microstructural damage correlates with memory impairment in clinically isolated syndrome suggestive of multiple sclerosis.
Academic Article The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.
Academic Article Characterizing Clinical and MRI Dissociation in Patients with Multiple Sclerosis.
Academic Article Exploration of machine learning techniques in predicting multiple sclerosis disease course.
Academic Article The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis.
Academic Article Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis.
Academic Article Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI.
Academic Article Changes to the septo-fornical area might play a role in the pathogenesis of anxiety in multiple sclerosis.
Academic Article Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences.
Academic Article Objective Evaluation of Multiple Sclerosis Lesion Segmentation using a Data Management and Processing Infrastructure.
Academic Article Evidence of axonal damage in cerebellar peduncles without T2-lesions in multiple sclerosis.
Academic Article Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression.
Academic Article Brain anatomical correlates of fatigue in multiple sclerosis.
Academic Article History of fatigue in multiple sclerosis is associated with grey matter atrophy.
Academic Article Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods.
Academic Article A novel classification of fatigue in multiple sclerosis based on longitudinal assessments.
Academic Article New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions.
Academic Article Temporal association of sNfL and gad-enhancing lesions in multiple sclerosis.
Academic Article Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort.
Academic Article Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study.
Academic Article MRI Lesion State Modulates the Relationship Between Serum Neurofilament Light and Age in Multiple Sclerosis.
Academic Article Microstructural Changes in the Left Mesocorticolimbic Pathway are Associated with the Comorbid Development of Fatigue and Depression in Multiple Sclerosis.
Academic Article Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data.
Academic Article Usability of a Mobile App for Real-Time Assessment of Fatigue and Related Symptoms in Patients With Multiple Sclerosis: Observational Study.
Academic Article Development and evaluation of a manual segmentation protocol for deep grey matter in multiple sclerosis: Towards accelerated semi-automated references.
Academic Article Author Correction: Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.