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One or more keywords matched the following items that are connected to Kaelin, William
Item TypeName
Academic Article Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Academic Article How oxygen makes its presence felt.
Academic Article The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer.
Academic Article HIF hydroxylation and the mammalian oxygen-sensing pathway.
Academic Article Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Academic Article Proline hydroxylation and gene expression.
Academic Article The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing.
Academic Article HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Academic Article Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
Concept Hydroxylation
Academic Article Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Academic Article pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
Grant Real-Time Imaging of Hypoxia based on VHL Activity
Grant Real-Time Imaging of Hypoxia based on VHL Activity
Grant A Luciferase Fusion Protein Library to Identify &Monitor Ubiquitylation Targets
Academic Article PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
Academic Article VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Academic Article EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.
Search Criteria
  • Hydroxylation
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.