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overview My laboratory's major research focus is on liver fibrosis/cirrhosis. Specifically, we are investigating the basic mechanisms of progression and regression of liver scarring. Our goal is the development of non-invasive diagnostic tools to measure these processes in the clinic, and novel therapies to prevent and reverse cirrhosis and its life-threatening complications. We are actively working on the development, validation and optimization of small animal models for novel drug target discovery and efficacy testing. Some of our current basic research projects include the investigation of a novel macrophage-mediated pathway of fibrosis reversal, a role of intestinal microbiota in chronic liver disease, and elucidating the molecular mechanisms of fibrotic matrix stabilization and collagen cross-linking which make liver scarring irreversible.
One or more keywords matched the following items that are connected to Popov, Yury
Item TypeName
Academic Article Hepatic fibrosis: from bench to bedside.
Academic Article Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression.
Academic Article Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells.
Academic Article Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
Academic Article Role of the receptor for advanced glycation end products in hepatic fibrosis.
Academic Article Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells.
Academic Article Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes.
Academic Article Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis.
Academic Article Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.
Academic Article Epithelial-to-mesenchymal transition in liver fibrosis: dead or alive?
Academic Article Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies.
Academic Article Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis.
Academic Article Mouse model of primary biliary cirrhosis with progressive fibrosis: are we there yet?
Academic Article Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.
Academic Article Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies.
Academic Article Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis.
Academic Article Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice.
Academic Article CFTR dysfunction predisposes to fibrotic liver disease in a murine model.
Academic Article Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.
Concept Liver Cirrhosis, Experimental
Concept Liver Cirrhosis
Concept Liver Cirrhosis, Biliary
Academic Article Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation.
Academic Article Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.
Academic Article Vascular endothelial growth factor promotes fibrosis resolution and repair in mice.
Academic Article Extrahepatic platelet-derived growth factor-ß, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice.
Academic Article Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.
Academic Article A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer.
Academic Article Specific hepatic delivery of procollagen a1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis.
Academic Article Integrin avß6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.
Academic Article Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice.
Academic Article Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.
Academic Article Aspirin use is associated with lower indices of liver fibrosis among adults in the United States.
Academic Article Optimized Mouse Models for Liver Fibrosis.
Academic Article Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal.
Academic Article Contribution of Liver Nonparenchymal Cells to Hepatic Fibrosis: Interactions with the Local Microenvironment.
Academic Article Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis.
Academic Article Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.
Academic Article Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.
Academic Article Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer.
Academic Article Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis.
Academic Article Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis.
Academic Article 3D analysis of microvasculature in murine liver fibrosis models using synchrotron radiation-based microtomography.
Academic Article Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis.
Search Criteria
  • Liver Fibrosis
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.