Harvard Catalyst Profiles

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One or more keywords matched the following items that are connected to Tanzi, Rudolph
Item TypeName
Academic Article The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Academic Article Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Academic Article Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.
Academic Article Copper catalyzed oxidation of Alzheimer Abeta.
Academic Article Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.
Academic Article Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
Academic Article Metal chelation as a potential therapy for Alzheimer's disease.
Academic Article Mounting evidence for the involvement of zinc and copper in Alzheimer's disease.
Academic Article The galvanization of beta-amyloid in Alzheimer's disease.
Academic Article Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection.
Academic Article The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.
Academic Article Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Academic Article Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Academic Article Modulation of A beta adhesiveness and secretase site cleavage by zinc.
Academic Article PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses.
Academic Article Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.
Academic Article Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42.
Academic Article Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.
Academic Article Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Academic Article The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.
Academic Article Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats.
Academic Article 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Academic Article Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
Concept Copper
Academic Article The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants.
Search Criteria
  • Copper
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.