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overview Our research focuses on the investigation of immune responses against HIV at mucosal surfaces. The vast majority of HIV is transmitted following exposure to virus at a mucosal site. Mucosal tissues, particularly gut associated lymphoid tissue (GALT), also represents the main compartment of viral replication and the largest reservoir of latently infected cells. Despite this, HIV pathogenesis has primarily been studied in the most accessible compartment- the peripheral blood. However, only 2-3% of all lymphocytes reside in the blood- a small minority relative to the 70-90% of the body’s T and B cells that reside within mucosal tissues. One of the bottlenecks to obtaining a deeper understanding of immune responses against HIV at mucosal sites is the inherently small amount of material that can be obtained from mucosal sampling. We are therefore utilizing new cutting-edge technologies to simultaneously capture multiple measures of HIV-specific immune responses using small numbers of cells. Using these methodologies we have begun to map mucosal immune responses in the GALT and female reproductive tract at a level of resolution that has not been previously possible with existing technologies. We have also characterized how the microbiome at these mucosal surfaces impacts HIV acquisition and disease progression. See more details at: kwonlab.org
One or more keywords matched the following items that are connected to Kwon, Douglas
Item TypeName
Concept Metagenome
Academic Article Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome.
Grant Inflammation and the vaginal metagenome in HIV acquisition
Grant The enteric microbiome in treated and progressive HIV infection
Academic Article HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation.
Academic Article Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.
Academic Article Gut microbiota is critical for the induction of chemotherapy-induced pain.
Grant The enteric microbiome in HIV-associated chronic immune activation and cardiovascular disease
Academic Article Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity.
Academic Article The Influence of Cervicovaginal Microbiota on Mucosal Immunity and Prophylaxis in the Battle against HIV.
Grant Multi-omics characterization of HIV-associated changes in the gut microbiome and host mucosal immunity
Academic Article Capturing sequence diversity in metagenomes with comprehensive and scalable probe design.
Academic Article The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis.
Academic Article The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission.
Grant Impact of the vaginal microbiome on HVTN705 vaccine efficacy
Grant Phase 2 placebo-controlled randomized trial of LACTIN-V (Lactobacillus crispatus CTV-05) among women at high risk of HIV acquisition in Durban, South Africa
Academic Article Determinants of Vaginal Microbiota Composition.
Academic Article Bugs, drugs, and HIV: the role of the vaginal microbiome in HIV risk and antiretroviral efficacy for HIV prevention.
Academic Article Comparison of the vaginal microbiota in postmenopausal Black and White women.
Academic Article Modeling the temporal dynamics of cervicovaginal microbiota identifies targets that may promote reproductive health.
Academic Article Antigen Presenting Cells Link the Female Genital Tract Microbiome to Mucosal Inflammation, With Hormonal Contraception as an Additional Modulator of Inflammatory Signatures.
Academic Article Correction to: Modeling the temporal dynamics of cervicovaginal microbiota identifies targets that may promote reproductive health.
Search Criteria
  • Microbiota
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.