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One or more keywords matched the following properties of Lange, Christoph
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overview Research Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized the package in collaboration with GoldenHelix. Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc. Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics. Education Ph.D., 2000, University of Reading, United Kingdom
One or more keywords matched the following items that are connected to Lange, Christoph
Item TypeName
Academic Article Role of common and rare APP DNA sequence variants in Alzheimer disease.
Academic Article Genome-wide association scan of attention deficit hyperactivity disorder.
Academic Article Genomic screening and replication using the same data set in family-based association testing.
Academic Article Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
Academic Article Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected.
Academic Article Statistical challenges for genome-wide association studies of suicidality using family data.
Academic Article HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.
Academic Article Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan.
Academic Article Recommendations for using standardised phenotypes in genetic association studies.
Academic Article On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples.
Academic Article Quantitative trait prediction based on genetic marker-array data, a simulation study.
Academic Article A new testing strategy to identify rare variants with either risk or protective effect on disease.
Academic Article PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies.
Academic Article Stronger evidence for replication of NPPA using genome-wide genotyping data.
Academic Article CGene: an R package for implementation of causal genetic analyses.
Academic Article Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.
Academic Article Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
Academic Article On the frequency of copy number variants.
Academic Article Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
Academic Article 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate.
Academic Article Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease.
Academic Article Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
Academic Article Genomic screening in family-based association testing.
Academic Article On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls.
Academic Article Genome-wide association analysis of body mass in chronic obstructive pulmonary disease.
Academic Article Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
Academic Article Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium.
Academic Article Variants in FAM13A are associated with chronic obstructive pulmonary disease.
Academic Article An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes.
Academic Article Estimating the number of unseen variants in the human genome.
Academic Article On quality control measures in genome-wide association studies: a test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data.
Academic Article On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.
Academic Article A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
Academic Article Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample.
Academic Article Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis.
Academic Article Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
Academic Article Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
Academic Article On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects.
Academic Article A Bayesian approach to genetic association studies with family-based designs.
Academic Article Two-stage testing strategies for genome-wide association studies in family-based designs.
Academic Article Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.
Academic Article Family-based designs in the age of large-scale gene-association studies.
Academic Article P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R.
Academic Article Differentiating population stratification from genotyping error using family data.
Academic Article Genome-wide association studies of family data in pharmacogenetics: a case study.
Academic Article On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies.
Academic Article On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test.
Academic Article Genomics and genome-wide association studies: an integrative approach to expression QTL mapping.
Academic Article Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
Academic Article On the follow-up of genome-wide association studies: an overall test for the most promising SNPs.
Academic Article Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
Concept Genome-Wide Association Study
Concept Genome
Concept Genome, Human
Concept Genome, Viral
Academic Article A general semi-parametric approach to the analysis of genetic association studies in population-based designs.
Academic Article Sex-specific association of a common variant of the XG gene with autism spectrum disorders.
Academic Article Efficient strategy for detecting gene × gene joint action and its application in schizophrenia.
Academic Article A genome-wide association study of bronchodilator response in asthmatics.
Academic Article On the simultaneous association analysis of large genomic regions: a massive multi-locus association test.
Academic Article Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test.
Academic Article Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
Academic Article On rare-variant analysis in population-based designs: decomposing the likelihood to two informative components.
Academic Article Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.
Academic Article Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia.
Academic Article Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway.
Academic Article A novel method for detecting association between DNA methylation and diseases using spatial information.
Academic Article A general framework for robust and efficient association analysis in family-based designs: quantitative and dichotomous phenotypes.
Academic Article Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci.
Academic Article Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
Academic Article Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks.
Academic Article Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability.
Academic Article A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Academic Article On the Recombination Rate Estimation in the Presence of Population Substructure.
Academic Article Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project.
Academic Article Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease.
Grant Common Genetic Determinants of Asthma and COPD-PROGRAM PROJECT
Grant Systems Biology of Airway Disease
Grant Novel Statistical Approaches to Mental Health Phenotype Analysis in GWA Studies
Grant A New Approach to Mental Health Phenotypes in Family Genomewide Association
Academic Article Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests.
Academic Article Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.
Academic Article A general approach to testing for pleiotropy with rare and common variants.
Academic Article Gene-based segregation method for identifying rare variants in family-based sequencing studies.
Academic Article Identification of genetic outliers due to sub-structure and cryptic relationships.
Academic Article On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows.
Academic Article PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies.
Academic Article Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm.
Academic Article Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease.
Academic Article Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.
Academic Article Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.
Academic Article A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP.
Academic Article Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data.
Academic Article Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus.
Academic Article Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent.
Academic Article A novel locus for exertional dyspnoea in childhood asthma.
Academic Article locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies.
Academic Article Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus.
Academic Article Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.
Search Criteria
  • Genome
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.