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One or more keywords matched the following items that are connected to Geha, Raif
Item TypeName
Academic Article Regulation of IgE synthesis in humans: a tale of two signals.
Academic Article Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells.
Academic Article Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain.
Academic Article Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency.
Academic Article IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
Academic Article Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.
Academic Article Novel immune deficiencies: defective transcription of lymphokine genes.
Academic Article Engagement of CD14 on human monocytes terminates T cell proliferation by delivering a negative signal to T cells.
Academic Article The H1 histamine receptor regulates allergic lung responses.
Academic Article Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation.
Academic Article IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils.
Academic Article Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.
Academic Article The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen.
Academic Article Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.
Academic Article An immunodeficiency characterized by defective signal transduction in T lymphocytes.
Academic Article SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
Academic Article CD1d restricted natural killer T cells are not required for allergic skin inflammation.
Academic Article Hydrocortisone and IL-4 induce IgE isotype switching in human B cells.
Academic Article Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells.
Academic Article A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
Academic Article Induction of human T cell proliferation by a monoclonal antibody to CD5.
Academic Article Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV.
Academic Article An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis.
Academic Article Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells.
Academic Article Mechanisms of the failure of resting B cells to present tetanus toxoid antigen to T cells.
Academic Article Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands.
Academic Article Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes.
Academic Article Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene.
Academic Article Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.
Academic Article Regulation of IgE synthesis in humans.
Academic Article Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.
Academic Article Differential role of SLP-76 domains in T cell development and function.
Academic Article Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching.
Academic Article Interleukin 4 down-regulates the expression of CD14 in normal human monocytes.
Academic Article Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells.
Academic Article C4b-binding protein (C4BP) activates B cells through the CD40 receptor.
Academic Article Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome.
Academic Article Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses.
Academic Article Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone.
Academic Article Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact.
Academic Article IgE regulation and lymphokine patterns in aging humans.
Academic Article Immunosuppressant deoxyspergualin inhibits antigen processing in monocytes.
Academic Article Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.
Academic Article Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.
Academic Article Expression of the CD40 ligand in T lymphocytes and induction of IgE isotype switching.
Academic Article Decreased expression of the ligand for CD40 in newborn lymphocytes.
Academic Article Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
Academic Article CD40 ligation and IL-4 use different mechanisms of transcriptional activation of the human lymphotoxin alpha promoter in B cells.
Academic Article Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen.
Academic Article Molecular mechanisms of immunoglobulin E regulation.
Academic Article Molecular mechanisms of IgE regulation.
Academic Article Disodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells.
Academic Article Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.
Academic Article WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
Academic Article Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma.
Academic Article RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation.
Academic Article Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
Academic Article Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone.
Academic Article Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1.
Academic Article Regulation of IgE synthesis in humans.
Academic Article IL-10 is critical for Th2 responses in a murine model of allergic dermatitis.
Academic Article WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation.
Academic Article CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation.
Academic Article Mechanisms of inhibition of IgE synthesis by nedocromil sodium: nedocromil sodium inhibits deletional switch recombination in human B cells.
Academic Article Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells.
Academic Article Lymphokine profile in bone marrow transplant recipients.
Academic Article COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization.
Academic Article Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
Academic Article Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE.
Academic Article Regulation of IgE synthesis: from the membrane to the genes.
Academic Article WIP is critical for T cell responsiveness to IL-2.
Academic Article Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis.
Academic Article Role of protein tyrosine kinases and phosphatases in isotype switching: crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells.
Academic Article Severe combined immunodeficiency with selective T-cell cytokine genes.
Academic Article A protein of the AP-1 family is a component of nuclear factor of activated T cells.
Academic Article Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.
Academic Article Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb.
Academic Article Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis.
Academic Article Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3.
Academic Article Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1.
Academic Article CD40 ligation induces lymphotoxin alpha gene expression in human B cells.
Academic Article Interleukin-4 receptor expression by human B cells: functional analysis with a human interleukin-4 toxin, DAB389IL-4.
Academic Article CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.
Academic Article Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome.
Academic Article Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency.
Academic Article IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.
Academic Article Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes.
Academic Article Role of JAK3 in CD40-mediated signaling.
Academic Article Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations.
Academic Article Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.
Academic Article Novel immune deficiencies: defective transcription of lymphokine genes.
Academic Article The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription.
Academic Article Regulation of human IgE synthesis.
Concept Receptors, Interleukin
Concept Interleukin-18
Concept Interleukin-5
Concept Receptors, Interleukin-4
Concept Interleukin-2 Receptor alpha Subunit
Concept Interleukin-12
Concept Interleukin-1 Receptor-Associated Kinases
Concept Receptors, Interleukin-21
Concept Receptors, Interleukin-2
Concept Interleukin-17
Concept Interleukin-1beta
Concept Interleukin-4
Concept Interleukin-23
Concept Interleukin-6
Concept Interleukin-10
Concept Receptors, Interleukin-1
Concept Interleukin-13 Receptor alpha1 Subunit
Concept Interleukins
Concept Receptors, Interleukin-3
Concept Interleukin-1alpha
Concept Interleukin-1
Concept Interleukin-2
Concept Interleukin-3
Concept Interleukin-13
Concept Receptors, Interleukin-13
Academic Article TRIF signaling is essential for TLR4-driven IgE class switching.
Academic Article Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA.
Academic Article The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) mice.
Academic Article Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.
Academic Article IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells.
Academic Article Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis.
Academic Article IL-22 derived from ?d T cells restricts Staphylococcus aureus infection of mechanically injured skin.
Academic Article IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
Academic Article Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency.
Academic Article DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.
Academic Article DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.
Academic Article Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses.
Academic Article WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.
Academic Article IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice.
Academic Article MyD88 signaling in T regulatory cells by endogenous ligands dampens skin inflammation in filaggrin deficient mice.
Academic Article Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1a release.
Academic Article Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.
Search Criteria
  • Interleukins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.