Harvard Catalyst Profiles
Contact, publication, and social network information about Harvard faculty and fellows.
Open Source Software
to edit your profile (add a photo, awards, links to other websites, etc.)
Edit My Profile
My Person List (
Return to Top
Search Result Details
Back to Search Results
This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following items that are connected to
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.
The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
Aspartic Acid Endopeptidases
Synaptotagmins interact with APP and promote Aß generation.
Synapsin 1 promotes Aß generation via BACE1 modulation.
Limited Substrate Specificity of PS/?-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells.