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One or more keywords matched the following items that are connected to Berezovska, Oksana
Item TypeName
Academic Article Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Academic Article Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Academic Article Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Academic Article Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
Academic Article Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.
Academic Article The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
Academic Article Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Academic Article Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
Academic Article Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Academic Article Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Academic Article Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
Academic Article Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
Concept Aspartic Acid Endopeptidases
Concept Aspartic Acid
Academic Article Synaptotagmins interact with APP and promote Aß generation.
Academic Article Synapsin 1 promotes Aß generation via BACE1 modulation.
Academic Article Limited Substrate Specificity of PS/?-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells.
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  • Aspartic Acid
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.