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Genomic instability and endoreduplication triggered by RAD17 deletion.
ATRIP associates with replication protein A-coated ssDNA through multiple interactions.
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells.
Calcium Influx Guards Replication Forks against Exonuclease 1.