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One or more keywords matched the following items that are connected to Walsh, Christopher
Item TypeName
Academic Article Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17.
Academic Article Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid.
Academic Article Expressed protein ligation to probe regiospecificity of heterocyclization in the peptide antibiotic microcin B17.
Academic Article Genetics and assembly line enzymology of siderophore biosynthesis in bacteria.
Academic Article Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster.
Academic Article Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
Academic Article Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase.
Academic Article Dissection of the EntF condensation domain boundary and active site residues in nonribosomal peptide synthesis.
Academic Article Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry.
Academic Article Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.
Academic Article Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate.
Academic Article Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases.
Academic Article CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway.
Academic Article Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis.
Academic Article Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality.
Academic Article Toward efficient analysis of >70 kDa proteins with 100% sequence coverage.
Academic Article Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.
Academic Article Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase.
Academic Article Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.
Academic Article ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17.
Academic Article The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily.
Academic Article Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.
Academic Article Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa.
Academic Article Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains.
Academic Article Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces.
Academic Article Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: interaction of the 1-1382 and 1383-2035 fragments.
Academic Article Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme.
Academic Article Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis.
Academic Article Functional analysis of an interspecies chimera of acyl carrier proteins indicates a specialized domain for protein recognition.
Academic Article Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase.
Academic Article Cloning and characterization of the biosynthetic gene cluster for kutznerides.
Academic Article Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies.
Academic Article NRPS substrate promiscuity diversifies the xenematides.
Academic Article Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases.
Academic Article The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.
Academic Article A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection.
Academic Article Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.
Academic Article Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase.
Academic Article How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Academic Article Thiazole and oxazole peptides: biosynthesis and molecular machinery.
Academic Article Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization.
Academic Article Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine.
Academic Article A chemoenzymatic approach to glycopeptide antibiotics.
Academic Article In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites.
Academic Article Determinants for differential effects on D-Ala-D-lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci.
Academic Article In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities.
Academic Article Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
Academic Article Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function.
Academic Article The McbB component of microcin B17 synthetase is a zinc metalloprotein.
Academic Article Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity.
Academic Article Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases.
Academic Article The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides.
Academic Article A singular enzymatic megacomplex from Bacillus subtilis.
Academic Article Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic.
Academic Article Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.
Academic Article Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.
Academic Article Biomimetic synthesis and optimization of cyclic peptide antibiotics.
Academic Article The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.
Academic Article Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase.
Academic Article Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection.
Academic Article Structural analysis of an open active site conformation of nonheme iron halogenase CytC3.
Academic Article Anthranilate-activating modules from fungal nonribosomal peptide assembly lines.
Academic Article Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants.
Academic Article Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
Academic Article Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation.
Academic Article tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics.
Academic Article Mutational analysis of posttranslational heterocycle biosynthesis in the gyrase inhibitor microcin B17: distance dependence from propeptide and tolerance for substitution in a GSCG cyclizable sequence.
Concept Amino Acid Sequence
Academic Article Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain.
Academic Article The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds.
Academic Article Structural elements of an NRPS cyclization domain and its intermodule docking domain.
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  • Amino Acid Sequence
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.