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One or more keywords matched the following items that are connected to Kahn, C.
Item TypeName
Academic Article Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance.
Academic Article Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
Academic Article Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.
Academic Article beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes.
Academic Article An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
Academic Article Altered insulin signaling in retinal tissue in diabetic states.
Academic Article Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression.
Academic Article Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.
Academic Article The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system.
Academic Article Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.
Academic Article Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.
Academic Article Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Academic Article Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
Academic Article Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
Academic Article Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
Academic Article Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Academic Article Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
Academic Article Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes.
Academic Article Bidirectional modulation of insulin action by amino acids.
Academic Article Crosstalk between insulin and angiotensin II signalling systems.
Academic Article Insulin and the beta3-adrenoceptor differentially regulate uncoupling protein-1 expression.
Academic Article Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Academic Article Role of brain insulin receptor in control of body weight and reproduction.
Academic Article Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production.
Academic Article Expression and function of IRS-1 in insulin signal transmission.
Academic Article [Insulin signalization and molecular mechanisms of insulin resistance].
Academic Article Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Academic Article Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.
Academic Article A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
Academic Article Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
Academic Article Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.
Academic Article The role of insulin and IGF-1 signaling in longevity.
Academic Article Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia.
Academic Article Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice.
Academic Article Bi-directional regulation of brown fat adipogenesis by the insulin receptor.
Academic Article Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
Academic Article PI 3-kinase regulatory subunits as regulators of the unfolded protein response.
Academic Article Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
Academic Article Endocrine regulation of ageing.
Academic Article Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
Academic Article The insulin signaling system.
Academic Article Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice.
Academic Article Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.
Academic Article Extended longevity in mice lacking the insulin receptor in adipose tissue.
Academic Article Suppression of aging in mice by the hormone Klotho.
Academic Article Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.
Academic Article Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.
Academic Article Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha.
Academic Article Insulin receptor knockout mice.
Academic Article Role of insulin action and cell size on protein expression patterns in adipocytes.
Academic Article Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
Academic Article Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.
Academic Article Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Academic Article Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
Academic Article Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
Academic Article Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Academic Article SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
Academic Article Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.
Academic Article Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes.
Academic Article Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration.
Academic Article Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Academic Article The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.
Academic Article High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
Academic Article 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice.
Academic Article Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
Academic Article The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
Academic Article Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.
Academic Article Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Academic Article Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors.
Academic Article Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.
Academic Article Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Academic Article Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
Academic Article New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.
Academic Article Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Academic Article Insulin signalling and the regulation of glucose and lipid metabolism.
Academic Article Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.
Academic Article Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. I. Activation of protein kinase C stimulates tyrosine phosphorylation and activation of ErbB2 and ErbB3.
Academic Article Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. II. Comparison of phorbol ester and sphingomyelinase-induced phosphorylation of ErbB2 and ErbB3.
Academic Article Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
Academic Article Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Academic Article Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
Academic Article Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier.
Academic Article Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.
Academic Article Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.
Academic Article Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.
Academic Article Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.
Academic Article Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
Academic Article Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.
Academic Article Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation.
Academic Article Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.
Academic Article Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
Academic Article Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.
Academic Article Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
Academic Article GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.
Academic Article Transmembrane domain inversion blocks ER release and insulin receptor signaling.
Academic Article Critical nodes in signalling pathways: insights into insulin action.
Academic Article The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Academic Article Developmental origin of fat: tracking obesity to its source.
Academic Article Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
Academic Article Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.
Academic Article Molecular determinants of insulin action.
Academic Article Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.
Academic Article Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.
Academic Article Molecular determinants of insulin action.
Academic Article Insulin action and the insulin signaling network.
Academic Article Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.
Academic Article Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells.
Academic Article Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.
Academic Article beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
Academic Article From mice to men: insights into the insulin resistance syndromes.
Academic Article Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.
Academic Article TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.
Academic Article Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells.
Academic Article Effect of phospholipase treatment on insulin receptor signal transduction.
Academic Article Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
Academic Article Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Academic Article Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Academic Article The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.
Academic Article Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
Academic Article Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.
Academic Article A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.
Concept Signal Transduction
Academic Article Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1.
Academic Article Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-?.
Academic Article Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.
Academic Article Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Academic Article SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.
Academic Article Divergent roles of growth factors in the GnRH regulation of puberty in mice.
Academic Article Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease.
Academic Article Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors.
Academic Article Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.
Academic Article Insulin receptor signaling in normal and insulin-resistant states.
Academic Article Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.
Academic Article Insulin action in brain regulates systemic metabolism and brain function.
Academic Article Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.
Academic Article Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.
Academic Article Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.
Academic Article Effect of cholesterol reduction on receptor signaling in neurons.
Academic Article CDK4 is an essential insulin effector in adipocytes.
Academic Article Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance.
Academic Article Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability.
Academic Article Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.
Academic Article Antibiotic effects on gut microbiota and metabolism are host dependent.
Academic Article Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
Academic Article Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.
Academic Article Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.
Academic Article Insulin resistance in vascular endothelial cells promotes intestinal tumour formation.
Academic Article Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice.
Academic Article Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
Academic Article Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.
Academic Article Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action.
Academic Article Attenuation of PKCd enhances metabolic activity and promotes expansion of blood progenitors.
Academic Article Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.
Academic Article Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes.
Academic Article FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.
Academic Article Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.
Academic Article Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome.
Academic Article Insulin/IGF1 signalling mediates the effects of ß2 -adrenergic agonist on muscle proteostasis and growth.
Academic Article A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes.
Academic Article Characterization of viral insulins reveals white adipose tissue-specific effects in mice.
Academic Article Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.
Search Criteria
  • Pathway Signal Transduction
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.