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Item TypeName
Academic Article Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance.
Academic Article In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus.
Academic Article Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
Academic Article Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells.
Academic Article Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats.
Academic Article Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.
Academic Article Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle.
Academic Article Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.
Academic Article Adriamycin therapy for advanced insulinoma.
Academic Article Insulin induces the phosphorylation of DNA-binding nuclear proteins including lamins in 3T3-F442A.
Academic Article Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.
Academic Article beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes.
Academic Article Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.
Academic Article Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process.
Academic Article An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
Academic Article Altered insulin signaling in retinal tissue in diabetic states.
Academic Article Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression.
Academic Article Effects of phosphorylation on function of the Rad GTPase.
Academic Article Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display.
Academic Article Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
Academic Article Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.
Academic Article Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
Academic Article The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system.
Academic Article Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.
Academic Article Alterations in insulin receptor and substrate phosphorylation in hypertensive rats.
Academic Article Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
Academic Article Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.
Academic Article Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Academic Article Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
Academic Article The cellular fate of glucose and its relevance in type 2 diabetes.
Academic Article The insulin receptor--a critical link in glucose homeostasis and insulin action.
Academic Article Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice?
Academic Article Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Academic Article Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
Academic Article Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
Academic Article Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates.
Academic Article Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Academic Article Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains.
Academic Article Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.
Academic Article Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
Academic Article Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene.
Academic Article Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.
Academic Article Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes.
Academic Article Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro.
Academic Article Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system.
Academic Article Bidirectional modulation of insulin action by amino acids.
Academic Article Crosstalk between insulin and angiotensin II signalling systems.
Academic Article Insulin and the beta3-adrenoceptor differentially regulate uncoupling protein-1 expression.
Academic Article Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Academic Article Role of brain insulin receptor in control of body weight and reproduction.
Academic Article A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.
Academic Article Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
Academic Article Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.
Academic Article Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production.
Academic Article Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
Academic Article Expression and function of IRS-1 in insulin signal transmission.
Academic Article [Insulin signalization and molecular mechanisms of insulin resistance].
Academic Article Unraveling the mechanism of action of thiazolidinediones.
Academic Article Putting the genes for type II diabetes on the map.
Academic Article Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Academic Article Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.
Academic Article Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.
Academic Article Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
Academic Article A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
Academic Article Development of an in vitro reconstitution assay for glucose transporter 4 translocation.
Academic Article Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.
Academic Article Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
Academic Article The emerging genetic architecture of type 2 diabetes.
Academic Article Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
Academic Article A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Academic Article Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Academic Article Evidence for a circulating islet cell growth factor in insulin-resistant states.
Academic Article Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.
Academic Article Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.
Academic Article Insulin resistance: a look at the role of insulin receptor kinase.
Academic Article Mouse models of insulin resistance.
Academic Article High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats.
Academic Article Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.
Academic Article Berson, Yalow, and the JCI: the agony and the ecstasy.
Academic Article Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.
Academic Article Coordinate phosphorylation of insulin-receptor kinase and its 175,000-Mr endogenous substrate in rat hepatocytes.
Academic Article The role of insulin and IGF-1 signaling in longevity.
Academic Article Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia.
Academic Article Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice.
Academic Article Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome.
Academic Article Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase.
Academic Article Beneficial effects of subcutaneous fat transplantation on metabolism.
Academic Article New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Academic Article Bi-directional regulation of brown fat adipogenesis by the insulin receptor.
Academic Article The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells.
Academic Article Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.
Academic Article Triglycerides and toggling the tummy.
Academic Article The Joslin Diabetes Center.
Academic Article Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1.
Academic Article Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice.
Academic Article Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats.
Academic Article Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis.
Academic Article Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver.
Academic Article Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
Academic Article PI 3-kinase regulatory subunits as regulators of the unfolded protein response.
Academic Article Epidemiologic approach to the etiology of type I diabetes mellitus and its complications.
Academic Article Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor.
Academic Article Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.
Academic Article Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice.
Academic Article Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Academic Article Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
Academic Article Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.
Academic Article Endocrine regulation of ageing.
Academic Article Perverted priorities. The physician/scientist as spokesman and salesman for biomedical research. Presidential address to the American Society for Clinical Investigation, Washington, DC, 29 April 1989.
Academic Article Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone.
Academic Article Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
Academic Article Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility.
Academic Article Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Academic Article The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.
Academic Article Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice.
Academic Article Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice.
Academic Article Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes.
Academic Article Leptin therapy for type 1 diabetes gains traction.
Academic Article Cold but not sympathomimetics activates human brown adipose tissue in vivo.
Academic Article SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Academic Article Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies.
Academic Article Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
Academic Article Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
Academic Article The insulin signaling system.
Academic Article Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice.
Academic Article The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis.
Academic Article Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.
Academic Article Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action.
Academic Article Extended longevity in mice lacking the insulin receptor in adipose tissue.
Academic Article Insulin-like growth factor-mediated phosphorylation and protooncogene induction in Madin-Darby canine kidney cells.
Academic Article The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.
Academic Article Role for neuronal insulin resistance in neurodegenerative diseases.
Academic Article Suppression of aging in mice by the hormone Klotho.
Academic Article The differential role of Hif1ß/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation.
Academic Article Receptor antibodies as novel therapeutics for diabetes.
Academic Article An association between NIDDM and a GAA trinucleotide repeat polymorphism in the X25/frataxin (Friedreich's ataxia) gene.
Academic Article Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
Academic Article Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts.
Academic Article Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.
Academic Article Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha.
Academic Article Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.
Academic Article Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.
Academic Article Insulin receptor knockout mice.
Academic Article Role of insulin action and cell size on protein expression patterns in adipocytes.
Academic Article Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
Academic Article Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation.
Academic Article Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Academic Article A family of polypeptide substrates and inhibitors of insulin receptor kinase.
Academic Article Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.
Academic Article Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
Academic Article The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.
Academic Article Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Academic Article Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
Academic Article Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats.
Academic Article Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
Academic Article Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Academic Article Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
Academic Article Antioxidants prevent health-promoting effects of physical exercise in humans.
Academic Article SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
Academic Article Mitochondrial proton leak in obesity-resistant and obesity-prone mice.
Academic Article Central insulin action regulates peripheral glucose and fat metabolism in mice.
Academic Article Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.
Academic Article Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.
Academic Article Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
Academic Article Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes.
Academic Article Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration.
Academic Article IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Academic Article Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus.
Academic Article Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Academic Article Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies.
Academic Article Adipose depots possess unique developmental gene signatures.
Academic Article Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.
Academic Article Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice.
Academic Article Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes.
Academic Article Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells.
Academic Article Genetics of non-insulin-dependent (type-II) diabetes mellitus.
Academic Article Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging.
Academic Article The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.
Academic Article Ephs and ephrins keep pancreatic Beta cells connected.
Academic Article High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
Academic Article Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes.
Academic Article Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
Academic Article Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers.
Academic Article 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice.
Academic Article Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.
Academic Article Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.
Academic Article Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.
Academic Article Rad GTPase deficiency leads to cardiac hypertrophy.
Academic Article Molecular defects in the insulin receptor in patients with leprechaunism and in their parents.
Academic Article Health care reform--need for less emotion and more science.
Academic Article Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
Academic Article Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells.
Academic Article Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.
Academic Article Identification and importance of brown adipose tissue in adult humans.
Academic Article Differentiation-dependent phosphorylation of a 175,000 molecular weight protein in response to insulin and insulin-like growth factor-I in L6 skeletal muscle cells.
Academic Article The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
Academic Article Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells.
Academic Article Diabetes and insulin in regulation of brain cholesterol metabolism.
Academic Article Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.
Academic Article The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtubule-associated protein, and S6 kinases.
Academic Article Effect of dexamethasone on the carbohydrate chains of the insulin receptor.
Academic Article Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues.
Academic Article PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.
Academic Article The insulin receptor gene and its expression in insulin-resistant mice.
Academic Article Mir193b-365 is essential for brown fat differentiation.
Academic Article Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.
Academic Article Brown fat as a therapy for obesity and diabetes.
Academic Article Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.
Academic Article A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease.
Academic Article Cascade of autophosphorylation in the beta-subunit of the insulin receptor.
Academic Article SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Academic Article Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Academic Article Different pathways of postreceptor desensitization following chronic insulin treatment and in cells overexpressing constitutively active insulin receptors.
Academic Article Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.
Academic Article Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study.
Academic Article Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.
Academic Article Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
Academic Article New concepts in the pathogenesis of diabetes mellitus.
Academic Article Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.
Academic Article Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Academic Article Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
Academic Article Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Academic Article Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.
Academic Article New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.
Academic Article Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.
Academic Article Determinants of IDDM and perinatal mortality in children of diabetic mothers.
Academic Article Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Academic Article Insulin signalling and the regulation of glucose and lipid metabolism.
Academic Article Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.
Academic Article Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus.
Academic Article Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Academic Article Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.
Academic Article Insulin stimulates p70 S6 kinase in the nucleus of cells.
Academic Article Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. I. Activation of protein kinase C stimulates tyrosine phosphorylation and activation of ErbB2 and ErbB3.
Academic Article Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. II. Comparison of phorbol ester and sphingomyelinase-induced phosphorylation of ErbB2 and ErbB3.
Academic Article Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.
Academic Article Region-specific mRNA expression of phosphatidylinositol 3-kinase regulatory isoforms in the central nervous system of C57BL/6J mice.
Academic Article Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
Academic Article Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Academic Article Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
Academic Article Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
Academic Article Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.
Academic Article Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Academic Article Quantitative dissociation between EGF effects on c-myc and c-fos gene expression, DNA synthesis, and epidermal growth factor receptor tyrosine kinase activity.
Academic Article Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.
Academic Article Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier.
Academic Article PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.
Academic Article Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice.
Academic Article Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.
Academic Article Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.
Academic Article Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.
Academic Article Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases.
Academic Article Common and distinct elements in insulin and PDGF signaling.
Academic Article Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study.
Academic Article Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system.
Academic Article Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.
Academic Article Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.
Academic Article The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.
Academic Article Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.
Academic Article Approaches to the molecular cloning of protein-tyrosine phosphatases in insulin-sensitive tissues.
Academic Article Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro.
Academic Article Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.
Academic Article Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.
Academic Article Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
Academic Article Analysis of mRNA heterogeneity by ribonuclease H mapping: application to the insulin receptor.
Academic Article Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats.
Academic Article Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q.
Academic Article Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP.
Academic Article Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Academic Article Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.
Academic Article Transplantation of adipose tissue and stem cells: role in metabolism and disease.
Academic Article Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome.
Academic Article Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.
Academic Article Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
Academic Article Dietary carbohydrate, a Big Mac, and insulin requirements in type I diabetes.
Academic Article p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.
Academic Article Effects of insulin-sensitising agents in mice with hepatic insulin resistance.
Academic Article Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
Academic Article Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.
Academic Article Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Academic Article Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.
Academic Article Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
Academic Article Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.
Academic Article Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
Academic Article GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.
Academic Article Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.
Academic Article Insulin and epidermal growth factor stimulate phosphorylation of a 170-kDa protein in intact hepatocytes immunologically related to lipocortin 1.
Academic Article Mitochondria, obesity and aging.
Academic Article Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
Academic Article Transmembrane domain inversion blocks ER release and insulin receptor signaling.
Academic Article Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.
Academic Article Adiponectin: linking the fat cell to insulin sensitivity.
Academic Article Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Academic Article Critical nodes in signalling pathways: insights into insulin action.
Academic Article Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
Academic Article The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Academic Article Developmental origin of fat: tracking obesity to its source.
Academic Article Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
Academic Article Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.
Academic Article The insulin receptor and its substrate: molecular determinants of early events in insulin action.
Academic Article Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus.
Academic Article Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
Academic Article Molecular determinants of insulin action.
Academic Article Insulin allergy and insulin resistance.
Academic Article Picking a research problem. The critical decision.
Academic Article Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.
Academic Article Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
Academic Article Medicine. Can we nip obesity in its vascular bud?
Academic Article Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.
Academic Article Pancreatic function in carboxyl-ester lipase knockout mice.
Academic Article Phosphorylation of insulin-like growth factor I receptor by insulin receptor tyrosine kinase in intact cultured skeletal muscle cells.
Academic Article Transcriptional and posttranscriptional regulation of tyrosine aminotransferase by insulin in rat hepatoma cells.
Academic Article The insulin receptor and the molecular mechanism of insulin action.
Academic Article A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.
Academic Article Hepatic insulin resistance directly promotes formation of cholesterol gallstones.
Academic Article Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism.
Academic Article Insulin enhances glucose-stimulated insulin secretion in healthy humans.
Academic Article Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.
Academic Article Insulin receptor messenger ribonucleic acid sequence alterations detected by ribonuclease cleavage in patients with syndromes of insulin resistance.
Academic Article Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.
Academic Article Metabolic syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance?
Academic Article Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.
Academic Article Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats.
Academic Article Intrinsic differences in adipocyte precursor cells from different white fat depots.
Academic Article Initial processing of the insulin receptor precursor in vivo and in vitro.
Academic Article Risk of proliferative diabetic retinopathy in juvenile-onset type I diabetes: a 40-yr follow-up study.
Academic Article Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice.
Academic Article Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.
Academic Article Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.
Academic Article A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
Academic Article Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes.
Academic Article Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans.
Academic Article The changing natural history of nephropathy in type I diabetes.
Academic Article Altered expression and function of the insulin receptor in a family with lipoatrophic diabetes.
Academic Article Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1.
Academic Article Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells.
Academic Article Molecular determinants of insulin action.
Academic Article Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin.
Academic Article Insulin action and the insulin signaling network.
Academic Article Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes.
Academic Article Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.
Academic Article Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells.
Academic Article Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.
Academic Article beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
Academic Article Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance.
Academic Article Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice.
Academic Article Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.
Academic Article Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.
Academic Article Role of Foxa-2 in adipocyte metabolism and differentiation.
Academic Article Mosaic analysis of insulin receptor function.
Academic Article From mice to men: insights into the insulin resistance syndromes.
Academic Article Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.
Academic Article Modulation of expression of insulin and IGF-I receptor by Epstein-Barr virus and its gene products LMP and EBNA-2 in lymphocyte cell lines.
Academic Article Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.
Academic Article TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.
Academic Article Antibodies to the insulin receptor as tools in the study of receptor structure and function.
Academic Article A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
Academic Article Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.
Academic Article Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.
Academic Article Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose.
Academic Article Alterations in the hepatic insulin receptor kinase in genetic and acquired obesity in rats.
Academic Article Insulin-receptor gene and its expression in patients with insulin resistance.
Academic Article Role of microRNA processing in adipose tissue in stress defense and longevity.
Academic Article Acquired defect in interleukin-2 production in patients with type I diabetes mellitus.
Academic Article Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.
Academic Article Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei.
Academic Article Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
Academic Article Characterization and regulation of the mouse insulin receptor substrate gene promoter.
Academic Article Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells.
Academic Article Effect of phospholipase treatment on insulin receptor signal transduction.
Academic Article The ras-related protein rad associates with the cytoskeleton in a non-lipid-dependent manner.
Academic Article Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
Academic Article Diabetes: a strategic plan for the 21st century.
Academic Article Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice.
Academic Article Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans.
Academic Article Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Academic Article Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Academic Article The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.
Academic Article Prevalence of mutations in AGPAT2 among human lipodystrophies.
Academic Article Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
Academic Article Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
Academic Article Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.
Academic Article Evidence for a role of developmental genes in the origin of obesity and body fat distribution.
Academic Article Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.
Academic Article A patient with type B insulin resistance syndrome, responsive to immune therapy.
Academic Article Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome.
Academic Article Alterations in insulin receptor autophosphorylation in insulin resistance: correlation with altered sensitivity to glucose transport and antilipolysis to insulin.
Academic Article Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
Academic Article A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.
Concept Acanthosis Nigricans
Concept Immunohistochemistry
Concept Insulin-Like Growth Factor Binding Protein 1
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Concept Monosaccharide Transport Proteins
Concept Sirtuin 3
Concept Receptors, Adrenergic, beta-1
Concept Biological Evolution
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Concept Carotid Arteries
Concept Pituitary Gland
Concept Sequence Homology, Nucleic Acid
Concept Young Adult
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Concept Fasting
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Concept Animals, Genetically Modified
Concept Subcutaneous Fat, Abdominal
Concept Phosphoenolpyruvate Carboxylase
Concept 1-Phosphatidylinositol 4-Kinase
Concept Molecular Mimicry
Concept Anti-Obesity Agents
Concept Boston
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Concept Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
Concept Vasodilation
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Concept Fatty Acid Transport Proteins
Concept Alternative Splicing
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Concept Stress Fibers
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Concept Regeneration
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Concept rho GTP-Binding Proteins
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Concept Electron Transport Complex I
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Concept Electron Transport Complex IV
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Concept Up-Regulation
Concept Caspase 3
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Concept Insulin-Like Growth Factor II
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Concept Systole
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Concept Lipogenesis
Concept ATP-Binding Cassette Transporters
Concept Norepinephrine
Concept Overweight
Concept Trinucleotide Repeat Expansion
Concept ras Proteins
Concept Analysis of Variance
Concept Virulence Factors, Bordetella
Concept Weight Loss
Concept Amino Acid Transport System y+
Concept Feeding Behavior
Concept Atherosclerosis
Concept Hypothalamus, Anterior
Concept Vanadates
Concept Mice, 129 Strain
Concept Electron Transport Complex III
Concept Periodicals as Topic
Concept Calcium-Binding Proteins
Concept Metabolomics
Concept Spodoptera
Concept Nesting Behavior
Concept Response Elements
Concept Antioxidants
Concept Rotarod Performance Test
Concept Oxidation-Reduction
Concept Proto-Oncogene Proteins c-cbl
Concept Bucladesine
Concept Cytoskeleton
Concept Mitogen-Activated Protein Kinase 7
Concept Metronidazole
Concept Lipid Peroxidation
Concept Calcium
Concept Phosphothreonine
Concept Intracellular Membranes
Concept Nucleotide Mapping
Concept Coronary Vessels
Concept Precipitin Tests
Concept Hydrogen Peroxide
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Concept Cyclic AMP-Dependent Protein Kinases
Concept Colorectal Neoplasms
Concept STAT3 Transcription Factor
Concept TRPV Cation Channels
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Concept Blotting, Western
Concept Exosomes
Concept Ascorbic Acid
Concept Wolfram Syndrome
Concept Endocrinology
Concept Carbohydrate Sequence
Concept Sirtuins
Concept Mice, Nude
Concept Aminoimidazole Carboxamide
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Concept Case-Control Studies
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Concept Administration, Oral
Concept History, 19th Century
Concept Lysosomes
Concept Arginine
Concept Receptor, IGF Type 2
Concept Depression
Concept Amino Acids
Concept Combined Modality Therapy
Concept Dogs
Concept Phylogeny
Concept Chromones
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Concept Amino Acid Substitution
Concept Adrenergic beta-1 Receptor Antagonists
Concept Pentose Phosphate Pathway
Concept Binding, Competitive
Concept Blotting, Northern
Concept Hypothalamus
Concept Apoptosis Inducing Factor
Concept Vitamin E
Concept Thiazolidinediones
Concept Ovarian Follicle
Concept Mitogen-Activated Protein Kinase 1
Concept Disease Susceptibility
Concept Body Constitution
Concept Mammals
Concept Poly(ADP-ribose) Polymerases
Concept Sterol Regulatory Element Binding Protein 1
Concept Aged
Concept Encephalomyelitis, Autoimmune, Experimental
Concept 1-Methyl-3-isobutylxanthine
Concept GTP-Binding Protein gamma Subunits
Concept Electrophysiology
Concept Osteogenesis
Concept GRB2 Adaptor Protein
Concept Platelet-Derived Growth Factor
Concept Synaptic Transmission
Concept Adenosine Triphosphate
Concept Electron Transport Complex II
Concept Protein Biosynthesis
Concept Amino Acid Sequence
Concept Insulin-Like Growth Factor I
Concept Lipase
Concept Chromosomes, Human
Concept Receptors, G-Protein-Coupled
Concept Lipoprotein Lipase
Concept Mice, Knockout
Concept Rats, Inbred BB
Concept Saccharomyces cerevisiae
Concept Pituitary Neoplasms
Concept NADH Dehydrogenase
Concept Mice, Inbred Strains
Concept CCAAT-Enhancer-Binding Proteins
Concept Calcium Signaling
Concept NAD
Concept Obesity, Morbid
Concept Nitrites
Concept Eye Abnormalities
Concept Extracellular Signal-Regulated MAP Kinases
Concept Aldehyde Dehydrogenase
Concept Cell Size
Concept Glycine
Concept Ovary
Concept Receptors, Purinergic P2X5
Concept Electron Transport
Concept Fibroblast Growth Factor 1
Concept Leptin
Concept 3' Untranslated Regions
Concept Adipocytes, White
Concept Rats
Concept Housing, Animal
Concept Calcium-Transporting ATPases
Concept Collagen Type IV
Concept Complement C1q
Concept Sequence Homology, Amino Acid
Concept Diabetes Mellitus, Type 1
Concept Proto-Oncogene Proteins p21(ras)
Concept Succinate Dehydrogenase
Concept Autoradiography
Concept Thermogenesis
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 1
Concept Hemoglobins
Concept Peptide Mapping
Concept Wound Healing
Concept Kinetics
Concept Adipokines
Concept gamma-Aminobutyric Acid
Concept Biological Transport, Active
Concept Hypercalcemia
Concept Nucleic Acid Hybridization
Concept Cyclic AMP Response Element-Binding Protein
Concept Autoantibodies
Concept Citric Acid Cycle
Concept Ion Transport
Concept Phosphoenolpyruvate Carboxykinase (GTP)
Concept Glycogen Phosphorylase
Concept Synapses
Concept Phospholipases
Concept NADP
Concept Body Mass Index
Concept Tandem Mass Spectrometry
Concept Diagnosis, Differential
Concept Blotting, Southern
Concept Glutamine
Concept Vascular Endothelial Growth Factor A
Concept src Homology Domains
Concept Enzyme-Linked Immunosorbent Assay
Concept Protein Binding
Concept Neutrophils
Concept Intestinal Mucosa
Concept Muscular Dystrophies
Concept 1-Acylglycerol-3-Phosphate O-Acyltransferase
Concept DNA Methylation
Concept Apoptosis
Concept Receptors, Adrenergic, beta-2
Concept Calcium Channel Blockers
Concept Protein Transport
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Concept Hepatocyte Nuclear Factor 4
Concept Temperature
Concept Focal Adhesions
Concept Protein Prenylation
Concept Central Nervous System
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Concept Thinness
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Concept Spermatogenesis
Concept Methionine
Concept Thiazoles
Concept Terminology as Topic
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Concept Botulinum Toxins
Concept Protein Folding
Concept RNA, Small Interfering
Concept ras GTPase-Activating Proteins
Concept CCAAT-Enhancer-Binding Protein-alpha
Concept Blood-Brain Barrier
Concept Diabetes Mellitus, Lipoatrophic
Concept Angina Pectoris
Concept Calcimycin
Concept Mass Spectrometry
Concept Protein Processing, Post-Translational
Concept Adrenergic beta-Agonists
Concept Protein Structure, Secondary
Concept Activating Transcription Factor 6
Concept Somatomedins
Concept Ventromedial Hypothalamic Nucleus
Concept Chemistry
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Concept Cell Line, Tumor
Concept Brain-Derived Neurotrophic Factor
Concept Casein Kinase II
Concept Chromosomes, Human, Pair 2
Concept Fibroblast Growth Factor 9
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Carbohydrate Metabolism
Concept Pertussis Toxin
Concept RNA-Binding Proteins
Concept Protein Array Analysis
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Concept Mice, Inbred ICR
Concept Adenoma, Islet Cell
Concept MicroRNAs
Concept Cardiomyopathy, Dilated
Concept Zebrafish
Concept Biosynthetic Pathways
Concept Cyclic AMP
Concept Cold Temperature
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Concept Immune Sera
Concept Aspartic Acid
Concept Tryptophan
Concept Behavior, Animal
Concept Capillaries
Concept Exons
Concept Receptors, Adrenergic, beta
Concept Diabetes Mellitus, Type 2
Concept Basal Metabolism
Concept NF-E2-Related Factor 1
Concept Glucose Transporter Type 2
Concept CCAAT-Enhancer-Binding Protein-beta
Concept Ovariectomy
Concept Codon
Concept Mice, Inbred C57BL
Concept Chromosomes, Human, Pair 9
Concept Mosaicism
Concept Lysine
Concept Repetitive Sequences, Nucleic Acid
Concept Anti-Inflammatory Agents
Concept Back
Concept Proto-Oncogene Proteins c-akt
Concept Hepatocyte Nuclear Factor 1-beta
Concept Enzyme Activation
Concept Computational Biology
Concept Mitochondria, Liver
Concept Insulin-Secreting Cells
Concept Body Fat Distribution
Concept Nucleus Accumbens
Concept RNA Stability
Concept Alanine Transaminase
Concept Transcytosis
Concept Fibroblast Growth Factor 2
Concept Antidepressive Agents
Concept Amino Acid Motifs
Concept Neovascularization, Physiologic
Concept Azacitidine
Concept Receptor, erbB-3
Concept Adiposity
Concept Phenylalanine
Concept Follow-Up Studies
Concept Mice, Mutant Strains
Concept Body Composition
Concept Abnormalities, Multiple
Concept E2F1 Transcription Factor
Concept ets-Domain Protein Elk-1
Concept Molecular Structure
Concept Plasmapheresis
Concept Dimerization
Concept Tumor Necrosis Factor-alpha
Concept Middle Aged
Concept Hydrolysis
Concept Arabidopsis Proteins
Concept Mice, Neurologic Mutants
Concept Osmosis
Concept Glycolysis
Concept Rats, Sprague-Dawley
Concept beta-Galactosidase
Concept Epinephrine
Concept Paracrine Communication
Concept Adaptor Proteins, Vesicular Transport
Concept Hippocampus
Concept Chromatography, Affinity
Concept United States
Concept Aging
Concept Promoter Regions, Genetic
Concept Weight Gain
Concept Rats, Zucker
Concept Adaptation, Biological
Concept Cell Line, Transformed
Concept Calmodulin
Concept Cysteine
Concept Cyclin-Dependent Kinase 4
Concept Vascular Endothelial Growth Factors
Concept Olfactory Pathways
Concept Neprilysin
Concept Rats, Inbred SHR
Concept Receptors, Adrenergic, beta-3
Concept Multiple Myeloma
Concept Chaperonin 60
Concept Cholelithiasis
Concept Receptors, Interleukin-17
Concept MAP Kinase Signaling System
Concept Nobel Prize
Concept Humans
Concept Cerebellum
Concept Diazoxide
Concept Gluconeogenesis
Concept Doxorubicin
Concept Down-Regulation
Concept Deoxyribonuclease BamHI
Concept Brain Ischemia
Concept Xenopus laevis
Concept Cattle
Concept Cyclin D3
Concept Organ Size
Concept Cell Movement
Concept Amino Acid Transport Systems, Neutral
Concept beta Catenin
Concept Spinal Cord
Concept Suppressor of Cytokine Signaling Proteins
Concept Hematopoietic Stem Cells
Concept Proto-Oncogene Proteins c-sis
Concept Jejunum
Concept Rabbits
Concept Sirtuin 1
Concept Adrenergic beta-3 Receptor Agonists
Concept Lipolysis
Concept Hepatocyte Nuclear Factor 1-alpha
Concept Glucose Transporter Type 1
Concept Protein Structure, Tertiary
Concept Adaptor Proteins, Signal Transducing
Concept RNA Processing, Post-Transcriptional
Concept Glucose Transporter Type 4
Concept Base Composition
Concept Glucose Tolerance Test
Concept Glucose Clamp Technique
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Concept Lymphocytes
Concept Burkitt Lymphoma
Concept Androstadienes
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Concept Mitochondria
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Concept Cytochromes c
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Concept Tyrosine
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Concept Circular Dichroism
Concept Class I Phosphatidylinositol 3-Kinases
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Concept Phosphorylation
Concept MAP Kinase Kinase 1
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Concept Annexins
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Concept Unfolded Protein Response
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Concept Heterotrimeric GTP-Binding Proteins
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Concept Age of Onset
Concept Actins
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Concept Receptor, Fibroblast Growth Factor, Type 1
Concept Glycosylation
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Concept Membrane Potentials
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Concept Sterol Regulatory Element Binding Proteins
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Concept Vascular Cell Adhesion Molecule-1
Concept Receptor, IGF Type 1
Concept Intestine, Small
Concept Aryl Hydrocarbon Receptor Nuclear Translocator
Concept Sodium-Glucose Transporter 1
Academic Article Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.
Academic Article Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1.
Academic Article Shox2 is a molecular determinant of depot-specific adipocyte function.
Academic Article Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.
Academic Article Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Academic Article Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner.
Academic Article SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.
Academic Article Class IA phosphatidylinositol 3-kinase in pancreatic ß cells controls insulin secretion by multiple mechanisms.
Academic Article Divergent roles of growth factors in the GnRH regulation of puberty in mice.
Academic Article Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity.
Academic Article Turning on brown fat and muscle metabolism: hedging your bets.
Academic Article Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors.
Academic Article Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
Academic Article Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.
Academic Article Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.
Academic Article Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging.
Academic Article Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation.
Academic Article Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Academic Article A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species.
Academic Article Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice.
Academic Article p85a deficiency protects ß-cells from endoplasmic reticulum stress-induced apoptosis.
Academic Article Interplay between FGF21 and insulin action in the liver regulates metabolism.
Academic Article Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.
Academic Article Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.
Academic Article ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
Academic Article Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications.
Academic Article Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.
Academic Article Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells.
Academic Article Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.
Academic Article Severe insulin resistance alters metabolism in mesenchymal progenitor cells.
Academic Article Interplay between FGF21 and insulin action in the liver regulates metabolism.
Academic Article FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization.
Academic Article Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.
Academic Article Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity.
Academic Article Role of PKCd in Insulin Sensitivity and Skeletal Muscle Metabolism.
Academic Article CDK4 is an essential insulin effector in adipocytes.
Academic Article Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance.
Academic Article Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients.
Academic Article Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity.
Academic Article PI3-kinase mutation linked to insulin and growth factor resistance in vivo.
Academic Article Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease.
Academic Article Type 2 diabetes mellitus.
Academic Article Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain-Liver Connection.
Academic Article Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice.
Academic Article Effect of cholesterol reduction on receptor signaling in neurons.
Academic Article Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.
Academic Article Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5).
Academic Article Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability.
Academic Article Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.
Academic Article Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.
Academic Article Antibiotic effects on gut microbiota and metabolism are host dependent.
Academic Article Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.
Academic Article Bi-directional regulation of brown fat adipogenesis by the insulin receptor.
Academic Article Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.
Academic Article Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.
Academic Article Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor.
Academic Article Postnatal Growth Responses to Insulin-Like Growth Factor I in Insulin Receptor Substrate-1-Deficient Mice1.
Academic Article Positive and negative roles of p85a and p85ß regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
Academic Article Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
Academic Article Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.
Academic Article Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues.
Academic Article Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Academic Article Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.
Academic Article Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice.
Academic Article Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
Academic Article Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Academic Article Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity.
Academic Article Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes.
Academic Article Pyruvate induces torpor in obese mice.
Academic Article Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.
Academic Article Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.
Academic Article Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
Academic Article Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action.
Academic Article Insulin regulates astrocyte gliotransmission and modulates behavior.
Academic Article Regional differences in brain glucose metabolism determined by imaging mass spectrometry.
Academic Article Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes.
Academic Article Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.
Academic Article Hepatic deletion of p110a and p85a results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity.
Academic Article Attenuation of PKCd enhances metabolic activity and promotes expansion of blood progenitors.
Academic Article TRPV1 neurons regulate ß-cell function in a sex-dependent manner.
Academic Article Fatty liver disease: is it nonalcoholic fatty liver disease or obesity-associated fatty liver disease?
Academic Article Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
Academic Article Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
Academic Article Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.
Academic Article FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.
Academic Article Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.
Academic Article Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
Academic Article Viral Hormones: Expanding Dimensions in Endocrinology.
Academic Article Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.
Academic Article Identification of two microRNA nodes as potential cooperative modulators of liver metabolism.
Academic Article Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease.
Academic Article Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis.
Academic Article Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.
Academic Article Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.
Academic Article Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome.
Academic Article FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.
Academic Article Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver.
Academic Article Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity.
Academic Article Insulin/IGF1 signalling mediates the effects of ß2 -adrenergic agonist on muscle proteostasis and growth.
Academic Article Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance.
Academic Article Diabetes in ageing: pathways for developing the evidence base for clinical guidance.
Academic Article Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.