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One or more keywords matched the following items that are connected to Clardy, Jon
Item TypeName
Academic Article Honulactones: new bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena.
Academic Article Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella.
Academic Article Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Academic Article The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus.
Academic Article Synthesis and biological evaluation of analogues of the antibiotic pantocin B.
Academic Article Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: a potent and stereoselective NMDA receptor antagonist.
Academic Article Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium.
Academic Article High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development.
Academic Article Development of a fluorescence polarization based assay for histone deacetylase ligand discovery.
Academic Article Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge.
Academic Article Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water.
Academic Article Long-chain N-acyltyrosine synthases from environmental DNA.
Academic Article Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus.
Academic Article New antibiotics from bacterial natural products.
Academic Article Two new roridins isolated from Myrothecium sp.
Academic Article New natural product families from an environmental DNA (eDNA) gene cluster.
Academic Article Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.
Academic Article A chemical study of cyclic depsipeptides produced by a sponge-derived fungus.
Academic Article Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis.
Academic Article Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA.
Academic Article Colorimetric high-throughput screen for detection of heme crystallization inhibitors.
Academic Article High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Academic Article Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens.
Academic Article The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes.
Academic Article Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens.
Academic Article Unusual C25 steroids produced by a sponge-derived Penicillium citrinum.
Academic Article Antifungal diterpenoid alkaloids from Delphinium denudatum.
Academic Article Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
Academic Article Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus.
Academic Article Bactobolin resistance is conferred by mutations in the L2 ribosomal protein.
Academic Article Natural products: Beyond grind and find.
Academic Article FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.
Academic Article Topoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp.
Academic Article Letter: A revised structure of vermiculine. A novel macrolide dilactone antibiotic from Penicillium vermiculatum.
Academic Article Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery.
Academic Article The chemistry of signal transduction.
Academic Article CR377, a new pentaketide antifungal agent isolated from an endophytic fungus.
Academic Article Relative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp.
Academic Article Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.
Academic Article Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin.
Academic Article Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.
Academic Article Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom.
Academic Article Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Academic Article A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid.
Academic Article Preparation of a psammaplysene-based library.
Academic Article One pathway, many products.
Academic Article Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.
Academic Article Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
Academic Article Catecholate siderophores protect bacteria from pyochelin toxicity.
Academic Article A further study of the cytotoxic constituents of a milnamide-producing sponge.
Academic Article Isolation and structure/activity features of halomon-related antitumor monoterpenes from the red alga Portieria hornemannii.
Academic Article A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal.
Academic Article Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
Academic Article Siderophores from neighboring organisms promote the growth of uncultured bacteria.
Academic Article Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.
Academic Article Dictyoxepin and dictyolene, two new diterpenes from the marine alga Dictyota acutiloba (Phaeophyta)
Academic Article Structure of the spiroketal-macrolide ossamycin.
Academic Article Production of kanosamine by Bacillus cereus UW85.
Academic Article Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes.
Academic Article A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines.
Academic Article ZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A.
Academic Article Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride.
Academic Article The total synthesis of pantocin B.
Academic Article The cytosporones, new octaketide antibiotics isolated from an endophytic fungus.
Academic Article Oppositol, a brominated sesquiterpene alcohol of a new skeletal class from the red alga, Laurencia subopposita.
Academic Article Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115.
Academic Article The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
Academic Article Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp.
Academic Article Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.
Academic Article A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity.
Academic Article Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin.
Academic Article Tyrosol is a quorum-sensing molecule in Candida albicans.
Academic Article Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.
Academic Article Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes.
Academic Article FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells.
Academic Article Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.
Academic Article Bacterial protection of beetle-fungus mutualism.
Academic Article Fluoroprostaglandins: synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-, (-)-ent-12-fluoro-, (+)-15-epi-fluoro-, and (-)-ent-15 epi-12-fluoroprostaglandin F2 alpha.
Academic Article Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.
Academic Article Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases.
Academic Article Stopping trouble before it starts.
Academic Article Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85.
Academic Article Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Academic Article Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
Academic Article Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E.
Academic Article Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis.
Academic Article Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA.
Academic Article Actin-aggregating cucurbitacins from Physocarpus capitatus.
Academic Article Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.
Academic Article Rhizobium etli CE3 carries vir gene homologs on a self-transmissible plasmid.
Academic Article The biosynthetic gene cluster of Pantocin a provides insights into biosynthesis and a tool for screening.
Academic Article High-throughput Plasmodium falciparum growth assay for malaria drug discovery.
Academic Article Using the heat-shock response to discover anticancer compounds that target protein homeostasis.
Concept Antiparasitic Agents
Concept Base Sequence
Concept Neuroprotective Agents
Concept Antineoplastic Agents, Phytogenic
Concept Intercalating Agents
Concept Antineoplastic Agents
Concept Abortifacient Agents, Nonsteroidal
Concept Immunosuppressive Agents
Concept Vasodilator Agents
Concept Anti-Bacterial Agents
Concept Anti-Infective Agents
Concept Anti-HIV Agents
Concept Trypanocidal Agents
Concept Alkylating Agents
Concept Antiprotozoal Agents
Concept Antifungal Agents
Academic Article Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil).
Academic Article Closing in on a new treatment for sleeping sickness.
Academic Article Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor.
Academic Article Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery.
Academic Article Isolation and structural elucidation of an antioxidative agent, naphterpin.
Academic Article A new naphthaquinone antibiotic from a new species of yeast.
Academic Article Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.
Academic Article Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Academic Article A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth.
Academic Article Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.
Academic Article Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.
Academic Article A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.
Academic Article Discovery of Dual-Stage Malaria Inhibitors with New Targets.
Academic Article Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A.
Grant New England Regional Center of Excellence in Biodefense and Emerging Infectious D
Grant High-throughput Screens for P. falciparum Malaria (RMI)
Grant Centers for Medical Countermeasures Against Radiation
Grant An Undulator Resource for Structural Biology
Grant Phenotypic-based high throughput screens-Plasmodium(RMI)
Grant Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates
Grant Discovery of Natural Product based Drugs and Bioenergetic Materials from CR
Grant Structural and Functional Studies on Proteins
Grant International Center for the Evaluation of East Asian Botanicals for Cancer
Grant Target-Based High-Throughput Screens for Plasmodium falciparum Malaria
Grant Potential Drugs from Poorly Understood Costa Rican Biota
Grant Applications of Natural Products to Chemical Biology
Grant Chemical biology of bacterial symbionts
Academic Article Homodimericin A: A Complex Hexacyclic Fungal Metabolite.
Academic Article Compounds that select against the tetracycline-resistance efflux pump.
Academic Article Selvamicin, an atypical antifungal polyene from two alternative genomic contexts.
Academic Article A common bacterial metabolite elicits prion-based bypass of glucose repression.
Academic Article Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.
Academic Article The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.
Grant Chemical biology of bacterial symbionts
Grant Identification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopy
Academic Article Chemical Interaction among Termite-Associated Microbes.
Academic Article The Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds.
Academic Article Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.
Academic Article Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.
Academic Article A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae.
Academic Article Pyonitrins A-D: Chimeric Natural Products Produced by Pseudomonas protegens.
Academic Article Parsing Molecules for Drug Discovery.
Academic Article A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity.
Academic Article A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E.
Academic Article Burkholderia from Fungus Gardens of Fungus-Growing Ants Produces Antifungals That Inhibit the Specialized Parasite Escovopsis.
Academic Article A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.