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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice.