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One or more keywords matched the following items that are connected to Letai, Anthony
Item TypeName
Academic Article Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
Academic Article Restoring cancer's death sentence.
Academic Article Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
Academic Article Control of mitochondrial apoptosis by the Bcl-2 family.
Academic Article Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
Academic Article BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.
Academic Article BCL-2: found bound and drugged!
Academic Article Growth factor withdrawal and apoptosis: the middle game.
Academic Article Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.
Academic Article Rational design of therapeutics targeting the BCL-2 family: are some cancer cells primed for death but waiting for a final push?
Academic Article Targeting the B-cell lymphoma/leukemia 2 family in cancer.
Academic Article The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance.
Academic Article Mimicking the BH3 domain to kill cancer cells.
Academic Article Laying the foundations of programmed cell death.
Academic Article Regulation of Bcl-2 family proteins by posttranslational modifications.
Academic Article MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts.
Academic Article BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2.
Academic Article Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.
Academic Article BH3-only proteins and their effects on cancer.
Academic Article Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
Academic Article BCL2 suppresses PARP1 function and nonapoptotic cell death.
Academic Article Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML.
Academic Article Pharmacological manipulation of Bcl-2 family members to control cell death.
Academic Article BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.
Academic Article Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells.
Academic Article BCL-2 inhibition: stemming the tide of myeloid malignancies.
Academic Article Diagnosing and exploiting cancer's addiction to blocks in apoptosis.
Academic Article BH3 domains as BCL-2 inhibitors: prototype cancer therapeutics.
Academic Article The landscape of somatic copy-number alteration across human cancers.
Academic Article BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.
Academic Article An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Academic Article Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
Academic Article Antiapoptotic BCL-2 is required for maintenance of a model leukemia.
Concept bcl-X Protein
Concept Proto-Oncogene Proteins c-bcl-2
Academic Article BH3 profiling in whole cells by fluorimeter or FACS.
Academic Article Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition.
Academic Article BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions.
Academic Article Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
Academic Article Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.
Academic Article Priming BCL-2 to kill: the combination therapy of tamoxifen and ABT-199 in ER+ breast cancer.
Academic Article Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis.
Academic Article Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells.
Academic Article Bcl-xL controls a switch between cell death modes during mitotic arrest.
Academic Article Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts.
Academic Article Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.
Academic Article Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.
Academic Article Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
Academic Article RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
Academic Article Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.
Academic Article Cell Death and Cancer Therapy: Don't Forget to Kill the Cancer Cell!
Academic Article MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.
Academic Article Mitochondria-Judges and Executioners of Cell Death Sentences.
Academic Article BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.
Academic Article iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry.
Academic Article The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.
Academic Article Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.
Academic Article Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilization.
Academic Article Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
Academic Article Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.
Academic Article Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance.
Academic Article Bruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.
Academic Article Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
Academic Article Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Academic Article BCL-XL directly modulates RAS signalling to favour cancer cell stemness.
Academic Article Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.
Academic Article Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax.
Academic Article Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.
Academic Article BCL-2 inhibition in AML: an unexpected bonus?
Academic Article Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.
Academic Article Targeted inhibition of PI3Ka/d is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL.
Academic Article Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.
Academic Article Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling.
Academic Article Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer.
Academic Article Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.
Academic Article Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.
Academic Article Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes.
Academic Article Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.
Academic Article ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins.
Search Criteria
  • Proto Oncogene Proteins c bcl 6
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.