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One or more keywords matched the following items that are connected to Letai, Anthony
Item TypeName
Academic Article Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
Academic Article Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
Academic Article BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.
Academic Article Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.
Academic Article Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.
Academic Article BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1a.
Academic Article MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts.
Academic Article BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2.
Academic Article BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.
Academic Article Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells.
Academic Article Puma strikes Bax.
Academic Article BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.
Academic Article Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
Concept Apoptosis Regulatory Proteins
Academic Article BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.
Academic Article Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
Academic Article APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.
Academic Article Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
Academic Article Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.
Academic Article Mitochondria-Judges and Executioners of Cell Death Sentences.
Academic Article Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.
Academic Article Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance.
Academic Article Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Grant Reading mitochondrial apoptotic signaling to identify active cancer therapeutics
Search Criteria
  • Apoptosis Regulatory Proteins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.