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Loss of RBF1 changes glutamine catabolism.
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.