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One or more keywords matched the following items that are connected to Sayegh, Mohamed
Item TypeName
Academic Article Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients.
Academic Article Role of indirect allorecognition in allograft rejection.
Academic Article Peptide-mediated immunosuppression.
Academic Article Immunomodulatory functions of hyaluronate in the LEW-to-F344 model of chronic cardiac allograft rejection.
Academic Article Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats.
Academic Article Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade.
Academic Article Cytokine analysis of human renal allograft aspiration biopsy cultures supernatants predicts acute rejection.
Academic Article A rendezvous before rejection: where do T cells meet transplant antigens?
Academic Article Importance of hyperglycemia on the primary function of allogeneic islet transplants.
Academic Article Current and future immunosuppressive therapies: impact on chronic allograft dysfunction.
Academic Article Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection.
Academic Article Intrathymic immunomodulation of sensitized rat recipients of cardiac allografts: requirements for allorecognition pathways.
Academic Article CD4-targeted therapy and CD28-B7 costimulatory blockage may independently induce tolerance in sensitized allograft recipients.
Academic Article Immunomodulatory functions of low-molecular weight hyaluronate in an acute rat renal allograft rejection model.
Academic Article CD4-targeted therapy induces "infectious" tolerance to cardiac allografts in sensitized rat recipients.
Academic Article The role of donor and recipient B7-1 (CD80) in allograft rejection.
Academic Article Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody.
Academic Article T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection.
Academic Article Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo.
Academic Article Importance of the CD28/B7 costimulatory pathway in the development of chronic ductopenic rejection in a new model of orthotopic rat liver allotransplantation.
Academic Article CTLA4Ig and donor-specific transfusion prolongs cardiac allograft survival in the miniature swine.
Academic Article Mechanisms of targeting CD28 by a signaling monoclonal antibody in acute and chronic allograft rejection.
Academic Article Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy.
Academic Article Chronic blockade of CD28-B7-mediated T-cell costimulation by CTLA4Ig reduces intimal thickening in MHC class I and II incompatible mouse heart allografts.
Academic Article Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice.
Academic Article Evidence that therapeutic strategies targeted at CD4+ cells modulate accelerated rejection of cardiac allografts in sensitized rats by different mechanisms.
Academic Article The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant.
Academic Article Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection.
Academic Article Blocking of mononuclear cell accumulation, cytokine production, and endothelial activation within rat cardiac allografts by CD4 monoclonal antibody therapy.
Academic Article CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.
Academic Article Class II MHC allopeptide-specific T-cell clones transfer delayed type hypersensitivity responses in vivo.
Academic Article Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection.
Academic Article Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells.
Academic Article Therapeutic strategies targeted at CD4+ cells obviate accelerated rejection of cardiac allografts in sensitized rats.
Academic Article Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
Academic Article Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients.
Academic Article Allograft rejection mediated by memory T cells is resistant to regulation.
Academic Article Regulating rejection with cell therapy.
Academic Article Overcoming cardiac allograft vasculopathy (CAV) by inducing tolerance.
Academic Article Cellular and humoral mechanisms of vascularized allograft rejection induced by indirect recognition of donor MHC allopeptides.
Academic Article Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats.
Academic Article Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it.
Academic Article Tolerance and chronic rejection.
Academic Article Mechanisms of indirect allorecognition: characterization of MHC class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection.
Academic Article Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.
Academic Article Mechanisms underlying blockade of allograft acceptance by TLR ligands.
Academic Article PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.
Academic Article T-cell costimulatory blockade in experimental chronic cardiac allograft rejection: effects of cyclosporine and donor antigen.
Academic Article Effects of leflunomide and deoxyspergualin in the guinea pig-->rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin.
Academic Article Agonistic and antagonistic interactions between CTLA4Ig and donor alloantigens in sensitized rat recipients of cardiac allografts.
Academic Article Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment.
Academic Article Indirect allorecognition promotes the development of cardiac allograft vasculopathy.
Academic Article Challenges to achieving clinical transplantation tolerance.
Academic Article A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection.
Academic Article Allograft rejection in a new allospecific CD4+ TCR transgenic mouse.
Academic Article CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.
Academic Article Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.
Academic Article Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.
Academic Article T-cell costimulatory pathways in allograft rejection and tolerance.
Academic Article Specificity of CD4+CD25+ regulatory T cell function in alloimmunity.
Academic Article Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen.
Academic Article Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection.
Academic Article Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis.
Academic Article CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo.
Academic Article Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation.
Academic Article A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice.
Academic Article Role of nuclear factor of activated T cell (NFAT) transcription factors in skin and vascularized cardiac allograft rejection.
Academic Article Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model.
Academic Article Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients.
Academic Article Comparative strategies to induce long-term graft acceptance in fully allogeneic renal versus cardiac allograft models by CD28-B7 T cell costimulatory blockade: role of thymus and spleen.
Academic Article Effect of hepatocyte growth factor on chronic rejection in rat renal allografts.
Academic Article Distinct tolerance pathways in sensitized allograft recipients after selective blockade of activation signal 1 or signal 2.
Academic Article Regulatory T cells maintain peripheral tolerance to islet allografts induced by intrathymic injection of MHC class I allopeptides.
Academic Article The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection.
Academic Article Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection.
Academic Article Anti-CD4 monoclonal antibody effects cellular hyporesponsiveness and prolongs renal allograft survival in the rat.
Academic Article Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†).
Academic Article Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.
Academic Article Rejection of mouse cardiac allografts by costimulation in trans.
Academic Article Immunologic tolerance to renal allografts after bone marrow transplants from the same donors.
Academic Article CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy.
Academic Article Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo.
Academic Article Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Academic Article Transplant nephrectomy improves survival following a failed renal allograft.
Academic Article Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides.
Academic Article Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice.
Academic Article TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy.
Academic Article Abrogation of accelerated allograft rejection by intrathymic injection of donor spleen cells is associated with upregulation of donor-reactive IgM, IgG1, and IgG2A, but depression of IgG2B in the circulation and at the graft site.
Academic Article Detection of cardiac myosin-specific autoimmunity in a model of chronic heart allograft rejection.
Academic Article New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.
Academic Article Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival.
Academic Article A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.
Academic Article New insights in CD28-independent allograft rejection.
Academic Article A pilot study on the immunological effects of oral administration of donor major histocompatibility complex class II peptides in renal transplant recipients.
Academic Article Dual effects of the alloresponse by Th1 and Th2 cells on acute and chronic rejection of allotransplants.
Academic Article Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts.
Academic Article Late renal allograft failure secondary to thrombotic microangiopathy-human immunodeficiency virus nephropathy.
Academic Article Intrathymic injection of donor-specific X-irradiation-sensitive spleen cells abrogates accelerated rejection of cardiac allografts in sensitized rats.
Academic Article Mechanisms of oral tolerance by MHC peptides.
Academic Article A novel in vivo regulatory role of P-glycoprotein in alloimmunity.
Academic Article Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts.
Academic Article Mesenteric and intraepithelial lymphocytes are insufficient to cause rejection but able to mediate lethal graft-versus-host disease in small bowel transplants.
Academic Article A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model.
Academic Article Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients.
Academic Article In vivo evidence for the Th1/Th2 paradigm: oral alloantigen-induced modulation of accelerated allograft rejection is associated with dense intragraft IL-4.
Academic Article Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.
Academic Article Synthetic MHC class I peptide prolongs cardiac survival and attenuates transplant arteriosclerosis in the Lewis-->Fischer 344 model of chronic allograft rejection.
Academic Article The importance of targeting the CD4+ T cell subset at the time of antigenic challenge for induction of prolonged vascularized allograft survival.
Academic Article TNF:TNF-R T-Cell costimulatory pathways in transplantation.
Academic Article Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine.
Academic Article Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection.
Academic Article Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses.
Academic Article Chronic allograft dysfunction: mechanisms and new approaches to therapy.
Academic Article Prolongation of survival and preservation of allograft structure and function by a signaling CD28 mAB in a rat model of chronic kidney rejection.
Academic Article The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade.
Academic Article Further analysis of the T-cell subsets and pathways of murine cardiac allograft rejection.
Academic Article Why do we reject a graft? Role of indirect allorecognition in graft rejection.
Academic Article Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy.
Academic Article Looking into the crystal ball: kidney transplantation in 2025.
Academic Article The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
Academic Article The alloantibody network following intrathymic immunomodulation of sensitized rat recipients of cardiac allografts.
Academic Article Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.
Academic Article Proinflammatory functions of vascular endothelial growth factor in alloimmunity.
Academic Article Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance.
Academic Article Downregulation of intragraft IFN-gamma expression correlates with increased IgG1 alloantibody response following intrathymic immunomodulation of sensitized rat recipients.
Academic Article Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized cardiac allografts before and after engraftment.
Academic Article Oral immunization with allogeneic splenocytes inhibits development of accelerated but not acute rejection of cardiac grafts: analysis of intragraft effector mechanisms.
Academic Article CTLA-4 up-regulation plays a role in tolerance mediated by CD45.
Academic Article Down-regulation of the immune response to histocompatibility antigens and prevention of sensitization by skin allografts by orally administered alloantigen.
Academic Article The indirect pathway of allorecognition. The occurrence of self-restricted T cell recognition of allo-MHC peptides early in acute renal allograft rejection and its inhibition by conventional immunosuppression.
Academic Article Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy.
Academic Article Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides.
Academic Article Regulatory T cells in transplantation: what we know and what we do not know.
Academic Article Intrathymic injection of donor splenocytes plus systemic antilymphocyte serum or antilymphocyte serum alone prolongs cardiac allograft survival and inhibits graft arteriosclerosis in the Lewis-to-F344 chronic rejection model.
Academic Article Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation.
Academic Article Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine.
Academic Article Inhibition of CD28-B7 T-cell costimulatory activation pathway affects intragraft cytokine and growth factor expression in chronic renal allograft rejection.
Academic Article A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy.
Academic Article The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.
Academic Article Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts.
Academic Article Intrathymic immunomodulation in sensitized rat recipients of cardiac allografts: requirements for allorecognition pathways.
Academic Article Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy.
Academic Article The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts.
Academic Article CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.
Academic Article Membranous lupus nephritis in a renal allograft: response to mycophenolate mofetil therapy.
Academic Article T-cell costimulatory pathways in allograft rejection and tolerance.
Academic Article Intrathymic tolerance in the Lewis-to-F344 chronic cardiac allograft rejection model.
Academic Article Intrathymic injection of allogeneic cells induces indefinite survival of cardiac but not small bowel grafts.
Academic Article Donor-specific transplantation unresponsiveness in sensitized rats following treatment with a nondepleting anti-CD4 MAb is associated with selective intragraft sparing of Th2-like cells.
Academic Article Chronic renal allograft dysfunction (CAD): new frontiers. Introduction.
Academic Article CD40 ligand-CD40 T cell costimulation pathway is required for host sensitization in the immune cascade leading to accelerated allograft rejection.
Academic Article B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
Academic Article Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants.
Academic Article The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation.
Academic Article Critical role of OX40 in CD28 and CD154-independent rejection.
Concept Transplantation, Homologous
Academic Article CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival.
Academic Article Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejection.
Academic Article TIM4 Regulates the Anti-Islet Th2 Alloimmune Response.
Academic Article ABCB5 Identifies Immunoregulatory Dermal Cells.
Grant INTRATHYMIC TRANSPLANTATION TOLERANCE BY MHC PEPTIDES
Grant Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
Grant INTRATHYMIC TRANSPLANTATION TOLERANCE BY MHC PEPTIDES
Grant The Role of TIM-1: TIM-4 Pathway in Allograft Rejection and Tolerance
Grant Role of Negative T Cell Costimulatory Pathways in Allograft Rejection and Toleran
Grant Immunopathogenesis of Chronic Allograft Rejection
Academic Article T cell costimulatory pathways in allograft rejection and tolerance: what's new?
Academic Article Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients.
Academic Article P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.
Academic Article Accelerated Allograft Vasculopathy With Rituximab After Cardiac Transplantation.
Academic Article Costimulation Blockade in Transplantation.
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  • Allograft
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.