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One or more keywords matched the following properties of Hu, Kun
keywords Nonlinear Dynamics
overview I obtained my doctoral training in statistical physics with a specific focus on nonlinear dynamic analysis and fractal physiology. During the first 5 years of my postdoctoral training, I have essentially involved in human experimental studies in two laboratories: Medical Chronobiology Program under the supervision of Dr. Steven Shea and Dr. Frank Scheer in the Division of Sleep and Circadian Disorders at BWH (sleep/circadian physiology); and SAFE (Syncope and Falls in the Elderly) Laboratory under the supervision of Dr. Vera Novak in the Division of Gerontology at Beth Israel Deaconess Medical Center (BIDMC) (for aging research). Between 2009-2011, I continued my advanced training in sleep/circadian physiology at BWH while learning about animal models involving neural lesions and gene knockouts in Dr. Clifford Saper’s lab in the Department of Neurology at BIDMC and in system biology under the guidance of Prof. Walter Fontana in the Department of System Biology at Harvard University. With my multidisciplinary training, I have been promoting the application of the concepts/methods derived from statistical physics and nonlinear dynamics in medicine during the last 16 years. To foster such translational research in sleep medicine, I established Medical Biodynamics Program (MBP) in the Division of Sleep Medicine at HMS (https://sleep.hms.harvard.edu/research/labs-divisions/medical-biodynamics-program-mbp). My research over the last decade years has been continuously funded by the NIH (K99 HL102241, R00 HL102241, R01AG048108, RF1AG059867, RF1AG064312). The on-going projects in our group are aimed to understand the physiological impacts of Alzheimer's disease, and to develop cost-efficient, non-invasive biomarkers for predicting and monitoring the progression of the disease.
One or more keywords matched the following items that are connected to Hu, Kun
Item TypeName
Academic Article White matter hyperintensities and dynamics of postural control.
Academic Article Non-random fluctuations and multi-scale dynamics regulation of human activity.
Academic Article Additive influences of the endogenous circadian system and mental stress on cardiovascular risk factors
Academic Article Multimodal Pressure Flow Analysis Enables Assessment of Cerebral Autoregulation Dynamics During Baseline Resting Conditions
Academic Article A nonlinear dynamic approach reveals a long-term stroke effect on cerebral blood flow regulation at multiple time scales.
Academic Article Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Academic Article Influences of postural tilt stress and the circadian system on cardiovascular risk factors
Academic Article Age and gender effects on postural control dynamics assessed by stabilogram-diffusion analysis
Academic Article Spurious detection of phase synchronization in coupled nonlinear oscillators.
Academic Article Influence of endogenous circadian system, physical exercise, and their interaction on cardiovascular risk factors
Academic Article Nonlinear pressure-flow relationship is able to detect asymmetry of brain blood circulation associated with midline shift.
Academic Article Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations.
Academic Article Novel multiscale regulation in human motor activity
Academic Article Effect of nonlinear filters on detrended fluctuation analysis.
Academic Article Analysis of EMG and acceleration signals for quantifying the effects of deep brain stimulation in Parkinson's disease.
Academic Article Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics.
Academic Article Synchronization patterns in cerebral blood flow and peripheral blood pressure after a minor stroke
Academic Article Nonlinear phase interaction between nonstationary signals: a comparison study of methods based on Hilbert-Huang and Fourier transforms.
Academic Article Effect of nonstationarities on detrended fluctuation analysis.
Academic Article Physiological complexity and system adaptability: evidence from postural control dynamics of older adults.
Academic Article Impact of the human circadian system, exercise, and their interaction on cardiovascular function.
Concept Autonomic Nervous System
Concept Nervous System Diseases
Concept Central Nervous System
Concept Cardiovascular System
Concept Heart Conduction System
Academic Article Effect of trends on detrended fluctuation analysis.
Academic Article The role of the circadian system in fractal neurophysiological control.
Academic Article Outlier-resilient complexity analysis of heartbeat dynamics.
Academic Article Anterior Insula Regulates Multiscale Temporal Organization of Sleep and Wake Activity.
Academic Article Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System.
Grant Harvard Older Americans Independence Center Grant
Grant Fractal Regulatory Function of the Circadian System
Grant Fractal Regulatory Function of the Circadian System
Grant Cerebromicrovascular disease in elderly with diabetes
Grant Neuropathology for disrupted multiscale activity control in Alzheimer's disease
Academic Article CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control.
Academic Article Impact of mental stress, the circadian system and their interaction on human cardiovascular function.
Academic Article The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans.
Grant Timing of Physical Activity on Cardiometabolic Health Outcomes
Grant Circadian/Sleep Disturbances and Systemic Inflammation in the Development of Delirium
Grant Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized Patients
Grant Sleep, Aging and Circadian Rhythm Disorders
Grant Circadian and behavioral factors of cardiovascular risk
Grant Effects of Circadian Disorders on the Complexity of Cardiac Dynamics
Grant Fractal regulatory function of the circadian system
Grant Chronobiology of cardiovascular and pulmonary disease
Search Criteria
  • System
  • dynamics
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.