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One or more keywords matched the following items that are connected to Lencer, Wayne
Item TypeName
Mentoring - Completed Student Project Cholera Toxin Endocytosis Via Ganglioside GM1 Enriched Detergent-Insoluble Membrane Microdomains: Molecular Mechanisms
Academic Article Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting.
Academic Article Salmonella pathogenesis: the trojan horse or the New York shuttle?
Academic Article A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.
Academic Article Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue.
Academic Article Floating the molecular machinery for t-cell activation.
Academic Article Acid secretion, ulcer disease, and cell biology.
Academic Article Floating cholera toxin into epithelial cells: functional association with caveolae-like detergent-insoluble membrane microdomains.
Academic Article Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin.
Academic Article N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.
Academic Article The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.
Academic Article A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity.
Academic Article Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine.
Academic Article Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung.
Academic Article Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells.
Academic Article Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway.
Academic Article The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function.
Academic Article Characterization of receptor-mediated signal transduction by Escherichia coli type IIa heat-labile enterotoxin in the polarized human intestinal cell line T84.
Academic Article Microbes and microbial Toxins: paradigms for microbial-mucosal toxins. V. Cholera: invasion of the intestinal epithelial barrier by a stably folded protein toxin.
Academic Article Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm.
Academic Article Patching a leaky intestine.
Academic Article Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
Academic Article Retrograde transport of cholera toxin into the ER of host cells.
Academic Article Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus.
Academic Article Characterization of the porcine neonatal Fc receptor--potential use for trans-epithelial protein delivery.
Academic Article Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate.
Academic Article The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins.
Academic Article The intracellular voyage of cholera toxin: going retro.
Academic Article Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.
Academic Article Paneth cells: on the front line or in the backfield?
Academic Article Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells.
Academic Article Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity.
Academic Article An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.
Academic Article Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia.
Academic Article Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.
Academic Article Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.
Academic Article Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.
Academic Article The potassium channel and how it works.
Academic Article Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1).
Academic Article Uncoupling of the cholera toxin-G(M1) ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of membrane cholesterol.
Academic Article Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
Academic Article A biochemical method for tracking cholera toxin transport from plasma membrane to Golgi and endoplasmic reticulum.
Academic Article Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.
Academic Article Dependence of antibody-mediated presentation of antigen on FcRn.
Academic Article Signal transduction by bacterial proteins.
Academic Article Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification.
Academic Article Discovery of dual-action membrane-anchored modulators of incretin receptors.
Academic Article Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.
Academic Article Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2.
Academic Article Differential binding kinetics of cholera toxin to intestinal microvillus membrane during development.
Academic Article Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3.
Academic Article The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells.
Academic Article Membrane traffic and the cellular uptake of cholera toxin.
Academic Article Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin.
Academic Article Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia.
Academic Article Raft trafficking of AB5 subunit bacterial toxins.
Academic Article Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation.
Academic Article Mucosal vaccination: "all politics are local".
Academic Article Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
Academic Article Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response.
Academic Article How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis.
Academic Article Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways.
Academic Article Endocytosis of cholera toxin by human enterocytes is developmentally regulated.
Academic Article Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
Academic Article A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway.
Academic Article The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.
Academic Article Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells.
Academic Article The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.
Academic Article Interaction of cholera toxin with cloned human goblet cells in monolayer culture.
Academic Article Carboxy-terminal vesicular stomatitis virus G protein-tagged intestinal Na+-dependent glucose cotransporter (SGLT1): maintenance of surface expression and global transport function with selective perturbation of transport kinetics and polarized expression.
Academic Article Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates.
Academic Article Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation.
Academic Article TorsinA participates in endoplasmic reticulum-associated degradation.
Academic Article Research agenda for pediatric gastroenterology, hepatology and nutrition: secretion and diarrhea. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation.
Academic Article Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure.
Academic Article Gangliosides are receptors for murine polyoma virus and SV40.
Academic Article Functional colocalization of water channels and proton pumps in endosomes from kidney proximal tubule.
Academic Article Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins.
Concept GTPase-Activating Proteins
Concept Lysosome-Associated Membrane Glycoproteins
Concept Structure-Activity Relationship
Concept cdc42 GTP-Binding Protein
Concept Electrophysiological Phenomena
Concept Cell Survival
Concept Substrate Specificity
Concept Transcription, Genetic
Concept Cell Differentiation
Concept Absorption
Concept Receptors, Guanylate Cyclase-Coupled
Concept Pregnancy
Concept Ion Channel Gating
Concept Lipid Metabolism
Concept Genome-Wide Association Study
Concept Protein Sorting Signals
Concept Cell Membrane Permeability
Concept Gene Knockdown Techniques
Concept Base Sequence
Concept Hydrogen-Ion Concentration
Concept Cell Compartmentation
Concept trans-Golgi Network
Concept Bacterial Physiological Phenomena
Concept Carbohydrate Conformation
Concept Gastric Mucosa
Concept Genetic Predisposition to Disease
Concept Genetic Loci
Concept Golgi Apparatus
Concept Intestinal Absorption
Concept Glioma
Concept Dose-Response Relationship, Drug
Concept Glycolipids
Concept Protein Denaturation
Concept Glycocalyx
Concept Enzyme Induction
Concept Transduction, Genetic
Concept Gene Targeting
Concept Adrenal Glands
Concept Binding Sites
Concept Genotype
Concept Genes, Dominant
Concept Blood Glucose
Concept Receptors, Glucagon
Concept Cytoplasmic Granules
Concept Green Fluorescent Proteins
Concept Guanylate Cyclase
Concept Membrane Fusion
Concept Lymphocyte Activation
Concept Gastric Acid
Concept Water-Electrolyte Balance
Concept Oxidation-Reduction
Concept Protein Stability
Concept Glycosphingolipids
Concept Electric Impedance
Concept Gastroenterology
Concept Immunity, Mucosal
Concept Polymorphism, Genetic
Concept Genetic Testing
Concept Child Nutritional Physiological Phenomena
Concept Receptors, Gastrointestinal Hormone
Concept Crystallization
Concept Homeostasis
Concept Amino Acid Sequence
Concept Algorithms
Concept Stress, Physiological
Concept Receptors, G-Protein-Coupled
Concept Calcium Signaling
Concept Gene Expression Regulation, Neoplastic
Concept Antibody Specificity
Concept Guinea Pigs
Concept Wound Healing
Concept Kinetics
Concept Maternal-Fetal Exchange
Concept Biological Transport, Active
Concept Cross-Priming
Concept Ion Transport
Concept Permeability
Concept Gene Expression Profiling
Concept Respiration
Concept Tissue Distribution
Concept Protein Binding
Concept Virulence
Concept Protein Transport
Concept Temperature
Concept Motor Activity
Concept Protein Folding
Concept Endocytosis
Concept Immunity, Active
Concept Protein Processing, Post-Translational
Concept Interferon-gamma
Concept Protein Structure, Secondary
Concept Glucose
Concept Molecular Sequence Data
Concept Conserved Sequence
Concept Half-Life
Concept Gangliosides
Concept Biosynthetic Pathways
Concept Immunity, Innate
Concept rab GTP-Binding Proteins
Concept Organ Specificity
Concept Exocytosis
Concept Cell Polarity
Concept Gene Expression Regulation
Concept Enzyme Activation
Concept Evolution, Molecular
Concept Protons
Concept Glucagon-Like Peptide 1
Concept Transcytosis
Concept Amino Acid Motifs
Concept Gene Expression Regulation, Bacterial
Concept Plasmids
Concept Mutation, Missense
Concept Molecular Structure
Concept Dimerization
Concept Point Mutation
Concept Transfection
Concept Hydrolysis
Concept Osmosis
Concept Glycoproteins
Concept United States
Concept Chromosomes, Human, Pair 6
Concept rhoA GTP-Binding Protein
Concept MAP Kinase Signaling System
Concept Down-Regulation
Concept Mutation
Concept Antigen Presentation
Concept Membrane Glycoproteins
Concept Scattering, Radiation
Concept Biological Transport
Concept Acylation
Concept Potassium Channels, Voltage-Gated
Concept Protein Structure, Tertiary
Concept Genetic Engineering
Concept Electrophoresis, Polyacrylamide Gel
Concept G(M1) Ganglioside
Concept Major Histocompatibility Complex
Concept Solubility
Concept Host-Pathogen Interactions
Concept Protein Conformation
Concept Gastric Inhibitory Polypeptide
Concept Phenotype
Concept Immunity, Maternally-Acquired
Concept Cell Proliferation
Concept Biotinylation
Concept Time Factors
Concept Drug Synergism
Concept Genes, MHC Class I
Concept Gap Junctions
Concept Phosphorylation
Concept North America
Concept Placental Circulation
Concept Surface Properties
Concept Signal Transduction
Concept Unfolded Protein Response
Concept Sequence Tagged Sites
Concept Gammaherpesvirinae
Concept Gene Expression
Concept Glycosylation
Concept Membrane Potentials
Concept Cell Communication
Concept RNA Interference
Concept Thermodynamics
Concept Polymorphism, Single Nucleotide
Concept Bacterial Adhesion
Concept Immunity
Concept Electric Conductivity
Concept Ubiquitination
Concept Sodium-Glucose Transporter 1
Academic Article The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling.
Academic Article Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules.
Academic Article Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain.
Academic Article Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.
Academic Article Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1.
Academic Article Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.
Academic Article Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen.
Academic Article 4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.
Academic Article Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics.
Academic Article Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway.
Academic Article Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W.
Academic Article Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.
Grant Intestinal Disease - enterocyte toxin interaction
Grant Intestinal Disease-enterocyte toxin interaction
Grant FASEB Summer Research Conference 2009
Grant Integrated Epithelial and Mucosal Biology
Grant FcRn-dependent sorting of IgG and IgG-opsinized antigens by epithelial cells
Grant Harnessing the biology of glycosphingolipid trafficking for biologic drug delivery
Grant Unsaturated glycoceramide as novel platform for mucosal vaccine and drug delivery
Grant Training in Pediatric Gastroenterology and Nutrition
Academic Article CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types.
Academic Article Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains.
Academic Article Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia.
Academic Article A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis.
Academic Article Opening CFTR in the Intestine: Flushing on Demand.
Academic Article Membrane Transport across Polarized Epithelia.
Academic Article Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.
Academic Article Retraction Notice to: The Unfolded Protein Response Element IRE1a Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.
Academic Article Advances in Evaluation of Chronic Diarrhea in Infants.
Academic Article Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.
Academic Article CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.
Academic Article INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.
Academic Article Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells.
Grant COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository
Academic Article A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response.
Academic Article A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization.
Academic Article IRE1ß negatively regulates IRE1a signaling in response to endoplasmic reticulum stress.
Academic Article Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers.
Academic Article Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin.
Grant Mechanisms of action for the IBD-risk gene INAVA: an epithelial guard receptor for inflammation and integrity of the intestinal barrier
Search Criteria
  • G
  • M1
  • Ganglioside
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.