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One or more keywords matched the following items that are connected to Ruvkun, Gary
Item TypeName
Academic Article The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
Academic Article A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Academic Article The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
Academic Article Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.
Academic Article Functional genomic analysis of RNA interference in C. elegans.
Academic Article VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth.
Academic Article Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.
Academic Article A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.
Academic Article The tiny RNA world.
Academic Article Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
Academic Article A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.
Academic Article Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
Academic Article The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
Academic Article A common theme for LIM homeobox gene function across phylogeny?
Academic Article C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.
Academic Article Detection of broadly expressed neuronal genes in C. elegans.
Academic Article The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
Academic Article The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.
Academic Article A novel repeat domain that is often associated with RING finger and B-box motifs.
Academic Article Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.
Academic Article Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.
Academic Article Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.
Academic Article Systematic analysis of genes required for synapse structure and function.
Academic Article Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.
Academic Article Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Academic Article The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification.
Academic Article An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
Academic Article Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
Academic Article Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Academic Article Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
Academic Article Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.
Academic Article MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.
Academic Article The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
Academic Article The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development.
Academic Article The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.
Academic Article The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.
Academic Article DAF-16 target genes that control C. elegans life-span and metabolism.
Academic Article PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.
Academic Article Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal.
Academic Article Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.
Academic Article Fat metabolism links germline stem cells and longevity in C. elegans.
Academic Article The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
Academic Article MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline.
Academic Article New insights into siRNA amplification and RNAi.
Academic Article Lifespan regulation by evolutionarily conserved genes essential for viability.
Academic Article A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
Academic Article daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Academic Article The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Academic Article Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.
Academic Article A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.
Academic Article The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.
Academic Article Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
Academic Article Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?
Academic Article Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.
Academic Article Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.
Academic Article Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.
Academic Article Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.
Academic Article Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.
Academic Article DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.
Academic Article The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.
Academic Article Analysis of xbx genes in C. elegans.
Academic Article A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.
Academic Article Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.
Academic Article mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
Academic Article The perfect storm of tiny RNAs.
Academic Article The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.
Academic Article Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway.
Academic Article Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.
Academic Article Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
Academic Article Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.
Academic Article Regulation of the C. elegans molt by pqn-47.
Academic Article Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.
Academic Article The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.
Academic Article A whole-genome RNAi Screen for C. elegans miRNA pathway genes.
Academic Article A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
Academic Article Prediction of C. elegans longevity genes by human and worm longevity networks.
Academic Article High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes.
Academic Article Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.
Academic Article Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
Academic Article Heterochronic genes in development and evolution.
Academic Article Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.
Academic Article daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.
Academic Article Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.
Academic Article ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
Concept Caenorhabditis elegans Proteins
Academic Article DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.
Academic Article MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
Academic Article Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death.
Academic Article Dual regulation of the lin-14 target mRNA by the lin-4 miRNA.
Academic Article Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.
Academic Article MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation.
Academic Article Caenorhabditis elegans pathways that surveil and defend mitochondria.
Academic Article Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.
Academic Article piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.
Academic Article Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.
Academic Article Dialogue between E. coli free radical pathways and the mitochondria of C. elegans.
Academic Article A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.
Academic Article Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
Academic Article The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes.
Academic Article Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs.
Academic Article Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.
Academic Article DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.
Academic Article Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes.
Academic Article Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression.
Academic Article Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity.
Academic Article Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons.
Academic Article Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism.
Academic Article Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response.
Academic Article Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.
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  • Caenorhabditis elegans Proteins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.