Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Login and Edit functionaility are currrently unavailable.

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following items that are connected to Cudkowicz, Merit
Item TypeName
Academic Article Administration of nitric oxide synthase inhibitors does not alter disease course of amyotrophic lateral sclerosis SOD1 mutant transgenic mice.
Academic Article An update on superoxide dismutase 1 in familial amyotrophic lateral sclerosis.
Academic Article Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.
Academic Article Basic fibroblast growth factor does not prolong survival in a transgenic model of familial amyotrophic lateral sclerosis.
Academic Article Coenzyme Q treatment of neurodegenerative diseases of aging.
Academic Article Increased CSF F2-isoprostane concentration in probable AD.
Academic Article Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies.
Academic Article Neuroprotective agents for clinical trials in ALS: a systematic assessment.
Academic Article Motor unit number estimation predicts disease onset and survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Academic Article The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis.
Academic Article A clinical trial of creatine in ALS.
Academic Article Validation of a new strength measurement device for amyotrophic lateral sclerosis clinical trials.
Academic Article Disease course unaltered by a single intracisternal injection of BMP-7 in ALS mice.
Academic Article Prospective study of cigarette smoking and amyotrophic lateral sclerosis.
Academic Article Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.
Academic Article Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells.
Academic Article Thrombopoietin is ineffective in a mouse model of motor neuron disease.
Academic Article Defining survival as an outcome measure in amyotrophic lateral sclerosis.
Academic Article Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.
Academic Article A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis.
Academic Article Effect of neurophilin ligands on motor units in mice with SOD1 ALS mutations.
Academic Article Prospective study of military service and mortality from ALS.
Academic Article Functional outcome measures as clinical trial endpoints in ALS.
Academic Article Is pentoxifylline safe and effective in patients with amyotrophic lateral sclerosis?
Academic Article Is erythropoietin a potential therapy for amyotrophic lateral sclerosis?
Academic Article Biomarkers for amyotrophic lateral sclerosis.
Academic Article Limited corticospinal tract involvement in amyotrophic lateral sclerosis subjects with the A4V mutation in the copper/zinc superoxide dismutase gene.
Academic Article Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis.
Academic Article IPLEX and the telephone game: the difficulty in separating myth from reality on the internet.
Academic Article Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis.
Academic Article North East ALS Study Group.
Academic Article Phase 2 study of sodium phenylbutyrate in ALS.
Academic Article SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy.
Academic Article Enhancing clinical trials in neurodegenerative disorders: lessons from amyotrophic lateral sclerosis.
Academic Article Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis.
Academic Article Lyme disease serology in amyotrophic lateral sclerosis.
Academic Article The Combined Assessment of Function and Survival (CAFS): a new endpoint for ALS clinical trials.
Academic Article Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis.
Academic Article Clinical trials in amyotrophic lateral sclerosis: the tenuous past and the promising future.
Academic Article Identification of potential CSF biomarkers in ALS.
Academic Article Biochemical alterations associated with ALS.
Academic Article 7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis.
Academic Article Measures and markers in amyotrophic lateral sclerosis.
Academic Article Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS).
Academic Article Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials.
Academic Article Galectin-3 is a candidate biomarker for amyotrophic lateral sclerosis: discovery by a proteomics approach.
Academic Article Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery.
Academic Article The natural history of ALS is changing: improved survival.
Academic Article Gender-based effect of statins on functional decline in amyotrophic lateral sclerosis.
Academic Article Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.
Academic Article Arimoclomol: a potential therapy under development for ALS.
Academic Article Emerging targets and treatments in amyotrophic lateral sclerosis.
Academic Article Medications and laboratory parameters as prognostic factors in amyotrophic lateral sclerosis.
Academic Article Proposed BioRepository platform solution for the ALS research community.
Academic Article Depression in amyotrophic lateral sclerosis.
Academic Article Therapy development for ALS: lessons learned and path forward.
Academic Article Toward more efficient clinical trials for amyotrophic lateral sclerosis.
Academic Article Uric acid levels predict survival in men with amyotrophic lateral sclerosis.
Academic Article What does body mass index measure in amyotrophic lateral sclerosis and why should we care?
Academic Article Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics.
Academic Article Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis.
Academic Article Detection of serum reverse transcriptase activity in patients with ALS and unaffected blood relatives.
Academic Article Trial of celecoxib in amyotrophic lateral sclerosis.
Academic Article A high-density genome-wide association screen of sporadic ALS in US veterans.
Academic Article Intrathecal administration of recombinant human superoxide dismutase 1 in amyotrophic lateral sclerosis: a preliminary safety and pharmacokinetic study.
Academic Article Design of phase II ALS clinical trials.
Academic Article The ALS Patient Care Database: insights into end-of-life care in ALS.
Academic Article Scrutinizing enrollment in ALS clinical trials: room for improvement?
Academic Article Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients.
Academic Article Vanadium, aluminum, magnesium and manganese are not elevated in hair samples in amyotrophic lateral sclerosis.
Academic Article Vitamin E intake and risk of amyotrophic lateral sclerosis.
Academic Article Comparison of incremental with multipoint MUNE methods in transgenic ALS mice.
Academic Article Maximum voluntary isometric contraction (MVIC).
Academic Article Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice.
Academic Article Phase II/III randomized trial of TCH346 in patients with ALS.
Academic Article Lithium therapy in ALS.
Academic Article Advanced statistical methods to study the effects of gastric tube and non-invasive ventilation on functional decline and survival in amyotrophic lateral sclerosis.
Academic Article The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis.
Academic Article Minocycline for patients with ALS.
Academic Article Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate.
Academic Article Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS.
Academic Article Is it too soon for mesenchymal stem cell trials in people with ALS?
Academic Article Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS.
Academic Article Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice.
Academic Article CSF markers in amyotrophic lateral sclerosis: has the time come?
Academic Article Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomics.
Academic Article Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis.
Academic Article The use of statistical MUNE in a multicenter clinical trial.
Academic Article Revised statistical motor unit number estimation in the Celecoxib/ALS trial.
Academic Article Increased incidence of deep venous thrombosis in ALS.
Academic Article Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis.
Academic Article A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis.
Academic Article Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity.
Academic Article Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis.
Academic Article Translating preclinical insights into effective human trials in ALS.
Academic Article Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.
Academic Article Clinical significance in the change of decline in ALSFRS-R.
Concept Multiple Sclerosis, Chronic Progressive
Concept Amyotrophic Lateral Sclerosis
Academic Article Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis.
Academic Article An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study.
Academic Article Analysis of start-up, retention, and adherence in ALS clinical trials.
Academic Article Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial.
Academic Article Post-lumbar puncture headache is reduced with use of atraumatic needles in ALS.
Academic Article Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.
Academic Article Predicting success: optimizing phase II ALS trials for the transition to phase III.
Academic Article Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial.
Academic Article Opportunities for improving therapy development in ALS.
Academic Article Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial.
Academic Article Diagnostic timelines and delays in diagnosing amyotrophic lateral sclerosis (ALS).
Academic Article Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics.
Academic Article A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS.
Academic Article Seeking a measure of clinically meaningful change in ALS.
Academic Article Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients with amyotrophic lateral sclerosis.
Academic Article Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.
Academic Article Neuroprotective agents target molecular mechanisms of disease in ALS.
Academic Article Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial.
Academic Article The PRO-ACT database: design, initial analyses, and predictive features.
Academic Article Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.
Academic Article Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.
Academic Article Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?
Academic Article Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression.
Academic Article Being PRO-ACTive: What can a Clinical Trial Database Reveal About ALS?
Academic Article Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis.
Academic Article Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort.
Academic Article Reply: To PMID 25900666.
Academic Article Cortical Hyperexcitability in Amyotrophic Lateral Sclerosis: C9orf72 Repeats.
Academic Article Primary Lateral Sclerosis and Early Upper Motor Neuron Disease: Characteristics of a Cross-Sectional Population.
Academic Article How common are ALS plateaus and reversals?
Academic Article A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.
Academic Article Job-related formaldehyde exposure and ALS mortality in the USA.
Academic Article The Role of Environmental Toxins in Amyotrophic Lateral Sclerosis Risk.
Academic Article Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials.
Academic Article Quantitative strength testing in ALS clinical trials.
Grant Phase II/III Study of Arimoclomol in the Treatment of SOD1 Positive Familial?.
Grant CLINICAL TRIAL OF TOPIRAMATE IN ALS
Grant Multi-Center Validation of Biomarkers for Motor Neuron Disease
Grant Clinical Trial of Ceftriaxone in ALS
Grant Generation and Characterization of Amyotrophic Lateral Sclerosis iPS cells
Grant Coenzyme Q10 in Huntington's Disease
Grant RISK FACTORS AND THERAPEUTIC STRATEGIES IN ALS
Grant Metabolomic Signatures in ALS
Grant Clinical Trial of Ceftriaxone in Subjects with ALS
Academic Article Design, rationale, and baseline characteristics of the randomized double-blind phase II clinical trial of ibudilast in progressive multiple sclerosis.
Academic Article New considerations in the design of clinical trials for amyotrophic lateral sclerosis.
Academic Article Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis.
Academic Article Defining SOD1 ALS natural history to guide therapeutic clinical trial design.
Academic Article Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis.
Academic Article Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial.
Academic Article Serum urate at trial entry and ALS progression in EMPOWER.
Academic Article Fixed dynamometry is more sensitive than vital capacity or ALS rating scale.
Academic Article Erratum to: Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial.
Academic Article Outcome measures in amyotrophic lateral sclerosis clinical trials.
Academic Article Functional Decline is Associated with Hopelessness in Amyotrophic Lateral Sclerosis (ALS).
Academic Article Urate levels predict survival in amyotrophic lateral sclerosis: Analysis of the expanded Pooled Resource Open-Access ALS clinical trials database.
Academic Article Imaging of glia activation in people with primary lateral sclerosis.
Academic Article A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis.
Academic Article An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis.
Academic Article VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics.
Academic Article Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive SOD1 ALS.
Academic Article Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double-blind crossover trial.
Academic Article Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Academic Article Respiratory measures in amyotrophic lateral sclerosis.
Academic Article Understanding the use of NIV in ALS: results of an international ALS specialist survey.
Academic Article Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis.
Academic Article Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models.
Academic Article Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.
Academic Article A pilot trial of RNS60 in amyotrophic lateral sclerosis.
Academic Article Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis.
Academic Article Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach.
Academic Article A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis.
Academic Article Nutritional counseling with or without mobile health technology: a randomized open-label standard-of-care-controlled trial in ALS.
Academic Article ALS/SURV: a modification of the CAFS statistic.
Academic Article Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers.
Academic Article Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis.
Academic Article IL6 receptor358Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis.
Academic Article NurOwn, phase 2, randomized, clinical trial in patients with ALS: Safety, clinical, and biomarker results.
Academic Article Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis.
Academic Article Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS.
Academic Article Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities.
Academic Article ALS clinical research learning institutes (ALS-CRLI): empowering people with ALS to be research ambassadors.
Academic Article SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS.
Academic Article Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Academic Article Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
Academic Article Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis.
Academic Article Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Academic Article Sodium Phenylbutyrate-Taurursodiol for ALS. Reply.
Academic Article Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.
Academic Article Improving clinical trial outcomes in amyotrophic lateral sclerosis.
Academic Article Regional prefrontal cortical atrophy predicts specific cognitive-behavioral symptoms in ALS-FTD.
Academic Article Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial.
Academic Article Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients.
Academic Article Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss.
Academic Article Medical therapies for amyotrophic lateral sclerosis-related respiratory decline: an appraisal of needs, opportunities and obstacles.
Academic Article Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design.
Academic Article Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial.
Search Criteria
  • Sclerosis
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.