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Search Results to Stuart Holland Orkin, M.D.

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Item TypeName
Academic Article Transcriptional control of erythropoiesis.
Academic Article Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
Academic Article Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.
Academic Article Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Academic Article Sequence of the human GATA-1 promoter.
Academic Article Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.
Academic Article Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.
Academic Article Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development.
Academic Article Guanine-adenine ligation-mediated PCR in vivo footprinting.
Academic Article Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells.
Academic Article GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.
Academic Article CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.
Academic Article Regulated expression of endothelin 1 in glomerular capillary endothelial cells.
Academic Article Consequences of GATA-1 deficiency in megakaryocytes and platelets.
Academic Article Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells.
Academic Article Thalassemia due to a mutation in the cleavage-polyadenylation signal of the human beta-globin gene.
Academic Article Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.
Academic Article The mutation and polymorphism of the human beta-globin gene and its surrounding DNA.
Academic Article Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location.
Academic Article Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1.
Academic Article Differential expression of alpha- and beta-globin genes during differentiation of cultured erythroleukemic cells.
Academic Article The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.
Academic Article Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.
Academic Article In vivo transcription of a human antithrombin III "minigene".
Academic Article Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins.
Academic Article Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.
Academic Article Activation of the erythropoietin receptor promoter by transcription factor GATA-1.
Academic Article Structure and transcription of the mouse erythropoietin receptor gene.
Academic Article Coregulator-dependent facilitation of chromatin occupancy by GATA-1.
Academic Article Cell-specific transcription and cell differentiation in the erythroid lineage.
Academic Article The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis.
Academic Article Differentiation in erythroleukemic cells and their somatic hybrids.
Academic Article The transcriptional control of hematopoiesis.
Academic Article TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Academic Article Mutation in an intervening sequence splice junction in man.
Academic Article DNA-binding specificity of GATA family transcription factors.
Academic Article Globin gene regulation and switching: circa 1990.
Academic Article Stem cells down under-ISSCR 2007.
Academic Article MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets.
Academic Article The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo.
Academic Article Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.
Academic Article Differentiation of murine erythroleukemic (Friend) cells: an in vitro model of erythropoiesis.
Academic Article Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma.
Academic Article Transcriptional regulation of erythropoiesis: an affair involving multiple partners.
Academic Article GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.
Academic Article Specific abnormalities of globin gene organization in the thalassemia syndromes.
Academic Article Regulation of globin gene expression in erythroid cells.
Academic Article Expression of GATA-binding proteins during embryonic development in Xenopus laevis.
Academic Article Chronic granulomatous disease. Molecular genetics.
Academic Article Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location.
Academic Article A functional initiator element in the human beta-globin promoter.
Academic Article The transcriptional network controlling pluripotency in ES cells.
Academic Article A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.
Academic Article Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: direct evidence for increased transcription during erythroid differentiation.
Academic Article PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
Academic Article Reverse genetics and human disease.
Academic Article Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells.
Academic Article Transcriptional silencing of fetal hemoglobin by BCL11A.
Academic Article Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.
Academic Article TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Academic Article Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.
Academic Article DNA polymorphism and molecular pathology of the human globin gene clusters.
Academic Article Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes.
Academic Article The thalassemias.
Academic Article Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.
Academic Article The human von Willebrand factor gene. Structure of the 5' region.
Academic Article Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes.
Academic Article Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
Academic Article Post-meiotic transcription of phosphoglycerate-kinase 2 in mouse testes.
Academic Article ATA box transcription mutation in beta-thalassemia.
Academic Article Polymorphism and molecular pathology of the human beta-globin gene.
Academic Article Fidelity of globin ribonucleic acid synthesis in vitro by isolated nuclei: asymmetric gene expression.
Academic Article A downstream element in the human beta-globin promoter: evidence of extended sequence-specific transcription factor IID contacts.
Academic Article Regulation of the beta-globin locus.
Academic Article Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.
Academic Article Transfer and expression of human ADA in murine hematopoietic stem cells.
Academic Article Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Academic Article Expression defects of mutant human adenosine deaminase.
Academic Article FOG acts as a repressor of red blood cell development in Xenopus.
Academic Article ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.
Academic Article Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors.
Academic Article The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease.
Academic Article Structural and functional defects in beta-thalassemia.
Concept Transcription, Genetic
Academic Article Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation.
Academic Article Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.
Academic Article Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.
Academic Article Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.
Academic Article Transcription control by the ENL YEATS domain in acute leukaemia.

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