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One or more keywords matched the following items that are connected to Orkin, Stuart
Item TypeName
Academic Article Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
Academic Article Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia.
Academic Article Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor.
Academic Article Medicine. Sickle cell disease at 100 years.
Academic Article DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.
Academic Article The mutation and polymorphism of the human beta-globin gene and its surrounding DNA.
Academic Article An erythroid-specific DNA binding factor mediates increased gamma-globin expression in hereditary persistence of fetal hemoglobin (HPFH).
Academic Article Saudi Arabian sickle cell anemia. A molecular approach.
Academic Article Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation.
Academic Article Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia.
Academic Article Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion.
Academic Article A functional element necessary for fetal hemoglobin silencing.
Academic Article Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.
Academic Article An alpha-globin gene initiation codon mutation in a black family with HbH disease.
Academic Article Modifier genes in Mendelian disorders: the example of hemoglobin disorders.
Academic Article The switch from fetal to adult hemoglobin.
Academic Article Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia.
Academic Article Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia.
Academic Article Reawakening fetal hemoglobin: prospects for new therapies for the ß-globin disorders.
Academic Article Fetal hemoglobin synthesis in erythroid cultures in hereditary persistence of fetal hemoglobin and beta o-thalassemia.
Academic Article Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.
Academic Article Advances in the understanding of haemoglobin switching.
Academic Article Hydroxyurea increases fetal hemoglobin production in sickle cell anemia.
Academic Article Transcriptional silencing of fetal hemoglobin by BCL11A.
Academic Article First occurrence of Hb H in Hungary.
Academic Article MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.
Academic Article Generation of a genomic reporter assay system for analysis of ?- and ß-globin gene regulation.
Academic Article Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia.
Academic Article The thalassemias.
Academic Article Therapeutic levels of fetal hemoglobin in erythroid progeny of ß-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.
Academic Article Update on fetal hemoglobin gene regulation in hemoglobinopathies.
Academic Article Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.
Academic Article Heterogeneity of DNA deletion in gamma delta beta-thalassemia.
Academic Article Prenatal diagnosis of hemoglobin disorders by DNA analysis.
Academic Article Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Academic Article High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined.
Academic Article The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease.
Academic Article Controlling the fetal globin switch in man.
Concept Fetal Hemoglobin
Concept Hemoglobin, Sickle
Concept Hemoglobin A
Concept Hemoglobin H
Academic Article Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.
Academic Article An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.
Academic Article The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
Academic Article miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.
Academic Article BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.
Academic Article 2014 William Allan Award: A hematologist's pursuit of hemoglobin genetics.
Academic Article BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.
Academic Article EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.
Academic Article Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.
Academic Article Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
Academic Article Recent advances in globin research using genome-wide association studies and gene editing.
Grant Extending GWAS at the BCL11A locus to novel therapeutics for HbF induction
Grant Molecular Analysis of Normal and Thalassemic DNA
Academic Article Strict in vivo specificity of the Bcl11a erythroid enhancer.
Academic Article Hemoglobin genetics: recent contributions of GWAS and gene editing.
Academic Article 14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.
Academic Article Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.
Academic Article Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.
Academic Article Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation.
Academic Article Transcription factor competition at the ?-globin promoters controls hemoglobin switching.
Academic Article Author Correction: Transcription factor competition at the ?-globin promoters controls hemoglobin switching.
Academic Article A unified model of human hemoglobin switching through single-cell genome editing.
Search Criteria
  • Hemoglobin C
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.