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One or more keywords matched the following items that are connected to Orkin, Stuart
Item TypeName
Academic Article FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Academic Article Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.
Academic Article PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding.
Academic Article Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development.
Academic Article Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies.
Academic Article Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse.
Academic Article Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Academic Article Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements.
Academic Article Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
Academic Article Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.
Academic Article Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation.
Academic Article Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Academic Article Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.
Academic Article Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.
Academic Article The transcription factor GATA2 regulates differentiation of brown adipocytes.
Academic Article The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.
Academic Article Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.
Academic Article GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
Academic Article Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis.
Academic Article Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
Academic Article Guanine-adenine ligation-mediated PCR in vivo footprinting.
Academic Article The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila.
Academic Article Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse.
Academic Article Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.
Academic Article A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.
Academic Article Medicine. Sickle cell disease at 100 years.
Academic Article Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.
Academic Article FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.
Academic Article GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.
Academic Article CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.
Academic Article Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.
Academic Article Priming the hematopoietic pump.
Academic Article Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression.
Academic Article Consequences of GATA-1 deficiency in megakaryocytes and platelets.
Academic Article GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors.
Academic Article Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.
Academic Article Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location.
Academic Article A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.
Academic Article Developmental and species-divergent globin switching are driven by BCL11A.
Academic Article Systematic tracking of cell fate changes.
Academic Article Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1.
Academic Article Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1.
Academic Article Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.
Academic Article Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.
Academic Article MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity.
Academic Article The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.
Academic Article A functional element necessary for fetal hemoglobin silencing.
Academic Article The molecular genetics of thalassemia.
Academic Article Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system.
Academic Article Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.
Academic Article Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube.
Academic Article Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Academic Article A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development.
Academic Article Basic fibroblast growth factor positively regulates hematopoietic development.
Academic Article The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis.
Academic Article Modifier genes in Mendelian disorders: the example of hemoglobin disorders.
Academic Article Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins.
Academic Article The transcriptional control of hematopoiesis.
Academic Article Polycomb repressive complex 2 regulates normal development of the mouse heart.
Academic Article Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors.
Academic Article TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Academic Article DNA-binding specificity of GATA family transcription factors.
Academic Article Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.
Academic Article ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.
Academic Article Globin gene regulation and switching: circa 1990.
Academic Article Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo.
Academic Article Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
Academic Article A single cis element maintains repression of the key developmental regulator Gata2.
Academic Article Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease.
Academic Article Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma.
Academic Article p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.
Academic Article Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.
Academic Article GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.
Academic Article The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.
Academic Article Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo.
Academic Article Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.
Academic Article FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Academic Article The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
Academic Article Somatic gene therapy. Current status and future prospects.
Academic Article Regulation of globin gene expression in erythroid cells.
Academic Article Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice.
Academic Article Gene therapy of somatic cells: status and prospects.
Academic Article Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice.
Academic Article Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain.
Academic Article Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.
Academic Article Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.
Academic Article Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.
Academic Article Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo.
Academic Article Differential roles of Sall4 isoforms in embryonic stem cell pluripotency.
Academic Article A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.
Academic Article ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.
Academic Article Advances in the understanding of haemoglobin switching.
Academic Article A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development.
Academic Article Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Academic Article The SWI/SNF complex--chromatin and cancer.
Academic Article Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
Academic Article PRC2 directly methylates GATA4 and represses its transcriptional activity.
Academic Article Generation of a genomic reporter assay system for analysis of ?- and ß-globin gene regulation.
Academic Article Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.
Academic Article Early pre-B cells from normal and X-linked agammaglobulinaemia produce C mu without an attached VH region.
Academic Article Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.
Academic Article miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.
Academic Article Update on fetal hemoglobin gene regulation in hemoglobinopathies.
Academic Article The human von Willebrand factor gene. Structure of the 5' region.
Academic Article Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.
Academic Article Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60.
Academic Article Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.
Academic Article CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.
Academic Article Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1.
Academic Article Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.
Academic Article Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
Academic Article Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer.
Academic Article Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution.
Academic Article Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity.
Academic Article In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region.
Academic Article The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia.
Academic Article Regulation of the beta-globin locus.
Academic Article Abnormal RNA splicing causes one form of alpha thalassemia.
Academic Article Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
Academic Article Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Academic Article The erythroid/myeloid lineage fate paradigm takes a new player.
Academic Article Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis.
Academic Article The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.
Academic Article ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.
Academic Article The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes.
Academic Article Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.
Academic Article Controlling the fetal globin switch in man.
Academic Article Structural and functional defects in beta-thalassemia.
Academic Article Abnormal RNA processing due to the exon mutation of beta E-globin gene.
Academic Article An early haematopoietic defect in mice lacking the transcription factor GATA-2.
Academic Article Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.
Concept Gene Expression Regulation, Neoplastic
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Leukemic
Academic Article Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.
Academic Article An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.
Academic Article Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner.
Academic Article Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.
Academic Article Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.
Academic Article Corepressor Rcor1 is essential for murine erythropoiesis.
Academic Article TMEM14C is required for erythroid mitochondrial heme metabolism.
Academic Article A comparative encyclopedia of DNA elements in the mouse genome.
Academic Article Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.
Academic Article Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis.
Academic Article Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.
Academic Article The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
Academic Article Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.
Academic Article BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.
Academic Article Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2.
Academic Article Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation.
Academic Article LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice.
Academic Article Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.
Academic Article Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.
Academic Article Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.
Academic Article Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.
Academic Article Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.
Academic Article An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation.
Academic Article Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells.
Academic Article Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.
Academic Article Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.
Academic Article The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.
Academic Article Transcription control by the ENL YEATS domain in acute leukaemia.
Academic Article Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells.
Academic Article PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.
Academic Article Dissecting super-enhancer hierarchy based on chromatin interactions.
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  • Gene Expression Regulation
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.