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One or more keywords matched the following items that are connected to Orkin, Stuart
Item TypeName
Academic Article Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG.
Academic Article Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse.
Academic Article Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.
Academic Article Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.
Academic Article Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression.
Academic Article Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus.
Academic Article Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion.
Academic Article A functional element necessary for fetal hemoglobin silencing.
Academic Article Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.
Academic Article Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Academic Article Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.
Academic Article TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Academic Article Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.
Academic Article A single cis element maintains repression of the key developmental regulator Gata2.
Academic Article ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.
Academic Article E2F-1 functions in mice to promote apoptosis and suppress proliferation.
Concept Gene Deletion
Academic Article Corepressor Rcor1 is essential for murine erythropoiesis.
Academic Article Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.
Academic Article Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9.
Academic Article Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-ß signalling.
Academic Article Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment.
Search Criteria
  • Gene Deletion
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.