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One or more keywords matched the following items that are connected to Orkin, Stuart
Item TypeName
Academic Article FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Academic Article Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.
Academic Article PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding.
Academic Article Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse.
Academic Article Transcriptional control of erythropoiesis.
Academic Article Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells.
Academic Article Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo.
Academic Article Genetics of erythropoiesis: induced mutations in mice and zebrafish.
Academic Article Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG.
Academic Article The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.
Academic Article Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1.
Academic Article Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.
Academic Article GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
Academic Article A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.
Academic Article X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.
Academic Article Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo.
Academic Article An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.
Academic Article Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis.
Academic Article Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line.
Academic Article Cell-specific transcription and cell differentiation in the erythroid lineage.
Academic Article Networking erythropoiesis.
Academic Article Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.
Academic Article The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo.
Academic Article A single cis element maintains repression of the key developmental regulator Gata2.
Academic Article Differentiation of murine erythroleukemic (Friend) cells: an in vitro model of erythropoiesis.
Academic Article Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.
Academic Article Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins.
Academic Article Transcriptional regulation of erythropoiesis: an affair involving multiple partners.
Academic Article The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.
Academic Article Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells.
Academic Article Apoptosis. Cutting red-cell production.
Academic Article Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.
Academic Article Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo.
Academic Article Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.
Academic Article GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells).
Academic Article Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.
Academic Article TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Academic Article Context-dependent function of "GATA switch" sites in vivo.
Academic Article Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.
Academic Article Development of hematopoietic cells lacking transcription factor GATA-1.
Academic Article Therapeutic levels of fetal hemoglobin in erythroid progeny of ß-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.
Academic Article Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.
Academic Article Regulation of the beta-globin locus.
Academic Article Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Academic Article Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis.
Academic Article FOG acts as a repressor of red blood cell development in Xenopus.
Academic Article ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.
Academic Article High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined.
Concept Erythropoiesis
Academic Article Corepressor Rcor1 is essential for murine erythropoiesis.
Academic Article TMEM14C is required for erythroid mitochondrial heme metabolism.
Academic Article The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
Academic Article Functional footprinting of regulatory DNA.
Academic Article Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
Grant Systems Biology Analysis of Human Erythropoiesis
Academic Article Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.
Academic Article 14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.
Academic Article FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.
Academic Article Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation.
Academic Article Enhancer dependence of cell-type-specific gene expression increases with developmental age.
Academic Article Transcription factor competition at the ?-globin promoters controls hemoglobin switching.
Search Criteria
  • Erythropoiesis
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.