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One or more keywords matched the following items that are connected to Coyle, Joseph
Item TypeName
Academic Article Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.
Academic Article Glutamatergic mechanisms in schizophrenia.
Academic Article A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia.
Academic Article Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus.
Academic Article The role of glutamatergic neurotransmission in the pathophysiology of alcoholism.
Academic Article The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia.
Academic Article D-cycloserine added to clozapine for patients with schizophrenia.
Academic Article D-serine added to clozapine for the treatment of schizophrenia.
Academic Article Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment.
Academic Article Modulation of N-methyl-D-aspartate receptor function by glycine transport.
Academic Article MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia.
Academic Article NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons.
Academic Article Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia.
Academic Article The glutamatergic dysfunction hypothesis for schizophrenia.
Academic Article Glial metabolites of tryptophan and excitotoxicity: coming unglued.
Academic Article Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
Academic Article Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.
Academic Article Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal.
Academic Article Substance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms.
Academic Article Intracellular modulation of NMDA receptor function by antipsychotic drugs.
Academic Article A brief overview of N-acetylaspartate and N-acetylaspartylglutamate.
Academic Article Neuronal D-serine regulates dendritic architecture in the somatosensory cortex.
Academic Article N-acetylaspartate in neuropsychiatric disorders.
Academic Article Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
Academic Article Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction.
Academic Article NMDA receptor and schizophrenia: a brief history.
Academic Article Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function.
Academic Article Decoding schizophrenia.
Academic Article N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases.
Academic Article Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia.
Academic Article The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex.
Academic Article Glutamate and schizophrenia: beyond the dopamine hypothesis.
Academic Article Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia.
Academic Article Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers.
Academic Article NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia.
Academic Article Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia.
Academic Article NAAG, NMDA receptor and psychosis.
Academic Article The glutamatergic basis of human alcoholism.
Academic Article Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells.
Academic Article Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.
Academic Article The immunocytochemical localization of N-acetylaspartyl glutamate, its hydrolysing enzyme NAALADase, and the NMDAR-1 receptor at a vertebrate neuromuscular junction.
Academic Article N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.
Academic Article The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina.
Academic Article Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.
Academic Article Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia.
Academic Article The GABA-glutamate connection in schizophrenia: which is the proximate cause?
Academic Article Abnormal excitatory neurotransmitter metabolism in schizophrenic brains.
Concept Receptors, N-Methyl-D-Aspartate
Concept Aspartic Acid
Academic Article Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction.
Academic Article Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.
Academic Article D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI.
Academic Article Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction.
Academic Article In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia.
Academic Article Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice.
Academic Article The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond.
Academic Article Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse.
Academic Article Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.
Academic Article History of the Concept of Disconnectivity in Schizophrenia.
Academic Article An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia.
Academic Article The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis.
Academic Article Endogenous co-agonists of the NMDA receptor modulate contextual fear in trace conditioning.
Academic Article Schizophrenia: Basic and Clinical.
Academic Article Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury.
Academic Article N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse.
Academic Article Altered CREB Binding to Activity-Dependent Genes in Serine Racemase Deficient Mice, a Mouse Model of Schizophrenia.
Academic Article Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features.
Academic Article Glutamate hypothesis in schizophrenia.
Academic Article Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene.
Academic Article Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis.
Academic Article D-Serine, the Shape-Shifting NMDA Receptor Co-agonist.
Academic Article Postsynaptic Serine Racemase Regulates NMDA Receptor Function.
Academic Article Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.