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One or more keywords matched the following items that are connected to Griffin, James
Item TypeName
Academic Article Tyrosine phosphorylation of Shc is not required for proliferation or viability signaling by granulocyte-macrophage colony-stimulating factor in hematopoietic cell lines.
Academic Article p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.
Academic Article The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.
Academic Article Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Academic Article Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1).
Academic Article p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines.
Academic Article Bcr/Abl activates transcription of the Bcl-X gene through STAT5.
Academic Article t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Academic Article Mechanisms of transformation by the BCR/ABL oncogene.
Academic Article BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.
Academic Article Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.
Academic Article Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
Academic Article Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.
Academic Article Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling.
Academic Article Notch receptors and hematopoiesis.
Academic Article The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Academic Article SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL.
Academic Article Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.
Academic Article Drug resistance in mutant FLT3-positive AML.
Academic Article Mutated tyrosine kinases as therapeutic targets in myeloid leukemias.
Academic Article Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.
Academic Article Molecular mechanisms of transformation by the BCR-ABL oncogene.
Academic Article The C-terminus of c-ABL is required for proliferation and viability signaling in a c-ABL/erythropoietin receptor fusion protein.
Academic Article Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
Academic Article The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival.
Academic Article c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions.
Academic Article Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia.
Academic Article Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
Academic Article The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.
Academic Article Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease.
Academic Article A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia.
Academic Article Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.
Academic Article BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway.
Academic Article Surface immunoglobulin-mediated signal transduction involves rapid phosphorylation and activation of the protooncogene product Raf-1 in human B-cells.
Academic Article Signal transduction of the human granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins.
Academic Article NOTCH1-induced T-cell leukemia in transgenic zebrafish.
Academic Article Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways.
Academic Article Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line.
Academic Article Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.
Academic Article Involvement of the adapter protein CRKL in integrin-mediated adhesion.
Academic Article Phosphatidyl inositol signaling by BCR/ABL: opportunities for drug development.
Academic Article Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.
Academic Article Effects of recombinant human granulocyte and macrophage colony-stimulating factors on signal transduction pathways in human granulocytes.
Academic Article Critical role for Gab2 in transformation by BCR/ABL.
Academic Article The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells.
Academic Article The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
Academic Article The biology of GM-CSF: regulation of production and interaction with its receptor.
Academic Article Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Academic Article Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line.
Academic Article The human granulocyte-macrophage colony-stimulating factor receptor is capable of initiating signal transduction in NIH3T3 cells.
Academic Article Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.
Academic Article JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.
Academic Article NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a.
Academic Article Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Academic Article Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression.
Academic Article Signal transduction of steel factor and granulocyte-macrophage colony-stimulating factor: differential regulation of transcription factor and G1 cyclin gene expression, and of proliferation in the human factor-dependent cell line MO7.
Academic Article Following the cytokine signaling pathway to leukemogenesis: a chronology.
Academic Article Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.
Academic Article The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Academic Article Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion.
Academic Article Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
Academic Article The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
Academic Article Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
Academic Article FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins.
Academic Article Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.
Academic Article Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
Academic Article Granulocyte-macrophage colony-stimulating factor and steel factor induce phosphorylation of both unique and overlapping signal transduction intermediates in a human factor-dependent hematopoietic cell line.
Academic Article Hematopoietic growth factors signal through the formation of reactive oxygen species.
Academic Article Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor.
Academic Article Internalization of the granulocyte-macrophage colony-stimulating factor receptor is not required for induction of protein tyrosine phosphorylation in human myeloid cells.
Concept Signal Transduction
Academic Article Alternative splicing in chronic myeloid leukemia (CML): a novel therapeutic target?
Academic Article A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets.
Academic Article Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma.
Academic Article Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R.
Academic Article Combination therapy with nilotinib for drug-sensitive and drug-resistant BCR-ABL-positive leukemia and other malignancies.
Academic Article Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach.
Grant Abnormalities/Signal Transduction/Hematopoietic Disease
Grant ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS BY BCR/ABL
Academic Article Notch1 activation enhances proliferation via activation of cdc2 and delays differentiation of myeloid progenitors.
Academic Article The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations.
Search Criteria
  • Pathway Signal Transduction
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.