Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following items that are connected to Griffin, James
Item TypeName
Academic Article Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells.
Academic Article Tyrosine phosphorylation of Shc is not required for proliferation or viability signaling by granulocyte-macrophage colony-stimulating factor in hematopoietic cell lines.
Academic Article The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.
Academic Article The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells.
Academic Article Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro.
Academic Article The ABL kinase inhibitor STI571 does not affect survival of hematopoietic cells after ionizing radiation.
Academic Article The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase.
Academic Article Point mutations in the FLT3 gene in AML.
Academic Article Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors.
Academic Article BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.
Academic Article The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Academic Article Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.
Academic Article Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.
Academic Article Protein kinase activity associated with simian virus 40 T antigen.
Academic Article ARG tyrosine kinase activity is inhibited by STI571.
Academic Article The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.
Academic Article The roles of FLT3 in hematopoiesis and leukemia.
Academic Article PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.
Academic Article Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation.
Academic Article A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.
Academic Article Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells.
Academic Article Drug resistance in mutant FLT3-positive AML.
Academic Article Mutated tyrosine kinases as therapeutic targets in myeloid leukemias.
Academic Article Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms.
Academic Article FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.
Academic Article cdc2 gene expression at the G1 to S transition in human T lymphocytes.
Academic Article After chronic myelogenous leukemia: tyrosine kinase inhibitors in other hematologic malignancies.
Academic Article Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
Academic Article JAK2 gets histone H3 rolling.
Academic Article Development of 'DFG-out' inhibitors of gatekeeper mutant kinases.
Academic Article The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.
Academic Article Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia.
Academic Article Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
Academic Article The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.
Academic Article Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease.
Academic Article FLT3 tyrosine kinase as a target in acute leukemias.
Academic Article Activated Jak2 with the V617F point mutation promotes G1/S phase transition.
Academic Article A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia.
Academic Article BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway.
Academic Article Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Academic Article Surface immunoglobulin-mediated signal transduction involves rapid phosphorylation and activation of the protooncogene product Raf-1 in human B-cells.
Academic Article The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo.
Academic Article Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.
Academic Article Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells.
Academic Article Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia.
Academic Article Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways.
Academic Article The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
Academic Article Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line.
Academic Article Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line.
Academic Article Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.
Academic Article Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.
Academic Article Smac mimetics: implications for enhancement of targeted therapies in leukemia.
Academic Article Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells.
Academic Article Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study.
Academic Article Wnt/ß-catenin Pathway Modulates the Sensitivity of the Mutant FLT3 Receptor Kinase Inhibitors in a GSK-3ß Dependent Manner.
Academic Article Signaling functions of the tyrosine residues in the betac chain of the granulocyte-macrophage colony-stimulating factor receptor.
Academic Article Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.
Academic Article Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I.
Academic Article Role of FLT3 in leukemia.
Academic Article Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase.
Academic Article Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.
Academic Article The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells.
Academic Article The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
Academic Article Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).
Academic Article Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines.
Academic Article High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
Academic Article Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
Academic Article FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML.
Academic Article The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity.
Academic Article PKC 412 FLT3 inhibitor therapy in AML: results of a phase II trial.
Academic Article Interaction maps for kinase inhibitors.
Academic Article Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.
Academic Article Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.
Academic Article JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.
Academic Article NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a.
Academic Article Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
Academic Article Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression.
Academic Article Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.
Academic Article The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Academic Article Infection of hematopoietic and stromal cells in human continuous bone marrow cultures by a retroviral vector containing the neomycin resistance gene.
Academic Article Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.
Academic Article Beneficial effects of combining a type II ATP competitive inhibitor with an allosteric competitive inhibitor of BCR-ABL for the treatment of imatinib-sensitive and imatinib-resistant CML.
Academic Article Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
Academic Article The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
Academic Article Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells.
Academic Article Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
Academic Article FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins.
Academic Article Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.
Academic Article Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.
Academic Article The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.
Academic Article An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRa and kit.
Academic Article Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor.
Academic Article Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.
Academic Article A sensitive high-throughput method to detect activating mutations of Jak2 in peripheral-blood samples.
Academic Article Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells.
Academic Article Discovery and characterization of novel mutant FLT3 kinase inhibitors.
Concept Thymidine Kinase
Concept Kanamycin Kinase
Concept Mitogen-Activated Protein Kinase Kinases
Concept MAP Kinase Kinase Kinases
Concept Protamine Kinase
Concept Cyclin-Dependent Kinase 2
Concept Protein Kinase Inhibitors
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Mitogen-Activated Protein Kinase 1
Concept CDC2 Protein Kinase
Concept Janus Kinase 1
Concept TYK2 Kinase
Concept Glycogen Synthase Kinase 3
Concept Focal Adhesion Kinase 1
Concept Cyclin-Dependent Kinase Inhibitor p27
Concept Janus Kinase 2
Concept Cyclin-Dependent Kinase 4
Concept Protein Kinase C
Concept Focal Adhesion Kinase 2
Concept MAP Kinase Kinase 1
Concept fms-Like Tyrosine Kinase 3
Academic Article Comparing nilotinib with dasatinib as second-line therapies in patients with chronic myelogenous leukemia resistant or intolerant to imatinib -- a retrospective chart review analysis.
Academic Article Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
Academic Article NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML.
Academic Article Discovery of a selective irreversible BMX inhibitor for prostate cancer.
Academic Article Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma.
Academic Article Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R.
Academic Article Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach.
Academic Article Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells.
Academic Article Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML.
Grant ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS BY BCR/ABL
Grant Regulation of Hematopoiesis by Notch Receptors
Academic Article Characterization of selective and potent PI3Kd inhibitor (PI3KDIN- 015) for B-Cell malignances.
Academic Article Structure-guided development of covalent TAK1 inhibitors.
Academic Article Simultaneous inhibition of Vps34 kinase would enhance PI3Kd inhibitor cytotoxicity in the B-cell malignancies.
Academic Article Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Academic Article Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase.
Academic Article Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase.
Academic Article Inhibition of USP10 induces degradation of oncogenic FLT3.
Academic Article A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
Academic Article Midostaurin, a Natural Product-Derived Kinase Inhibitor Recently Approved for the Treatment of Hematological MalignanciesPublished as part of the Biochemistry series "Biochemistry to Bedside".
Academic Article Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition.
Academic Article Notch1 activation enhances proliferation via activation of cdc2 and delays differentiation of myeloid progenitors.
Academic Article Treatment patterns and healthcare resource utilization in patients with FLT3-mutated and wild-type acute myeloid leukemia: A medical chart study.
Academic Article Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies.
Academic Article The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations.
Academic Article Effects of the multi-kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia.
Academic Article Inhibition of the deubiquitinase USP10 induces degradation of SYK.
Academic Article Repurposing of Kinase Inhibitors for Treatment of COVID-19.
Search Criteria
  • Elongation Factor 2 Kinase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.