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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF.
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.
Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor.
MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma.
A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes.
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.
Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage.
An oncogenic role for ETV1 in melanoma.
PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
Oncogenic BRAF regulates oxidative metabolism via PGC1a and MITF.
"Lineage addiction" in human cancer: lessons from integrated genomics.
Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma.
Microphthalmia-Associated Transcription Factor
A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression.
Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation.
MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61.
Microphthalmia Associated Transcription Factor