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One or more keywords matched the following items that are connected to Hyman, Bradley
Item TypeName
Academic Article Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
Academic Article Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.
Academic Article Transgenic models of Alzheimer's disease: learning from animals.
Academic Article Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
Academic Article Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy.
Academic Article Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
Academic Article Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.
Academic Article A limited role for microglia in antibody mediated plaque clearance in APP mice.
Academic Article Serum cystatin C and the risk of Alzheimer disease in elderly men.
Academic Article Multiphoton microscopy and amyloid angiopathy.
Academic Article Tau suppression in a neurodegenerative mouse model improves memory function.
Academic Article Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
Academic Article Neuron recognition by parallel Potts segmentation.
Academic Article Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.
Academic Article Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Academic Article Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Academic Article Synaptic alterations in the rTg4510 mouse model of tauopathy.
Academic Article Fas receptor and neuronal cell death after spinal cord ischemia.
Academic Article Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease.
Academic Article Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Academic Article Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.
Academic Article Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.
Academic Article Detection of myelination using a novel histological probe.
Academic Article Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Academic Article Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.
Academic Article Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.
Academic Article Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice.
Academic Article Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons.
Academic Article Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study.
Academic Article Reversible memory loss in a mouse transgenic model of Alzheimer's disease.
Academic Article Alzheimer's disease: what multiphoton microscopy teaches us.
Academic Article Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
Academic Article Brain oligomeric ß-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice.
Academic Article Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease.
Academic Article Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
Academic Article Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice.
Academic Article Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.
Academic Article Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy.
Academic Article Dynamic feedback in an aggregation-disaggregation model.
Academic Article Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Academic Article Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Academic Article Family-based association between Alzheimer's disease and variants in UBQLN1.
Academic Article Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model.
Academic Article Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Academic Article Transcriptional dysregulation in a transgenic model of Parkinson disease.
Academic Article Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy.
Academic Article Caspase activation without apoptosis: insight into Aß initiation of neurodegeneration.
Academic Article Propagation of tau pathology in a model of early Alzheimer's disease.
Academic Article Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.
Academic Article Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Academic Article Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
Academic Article Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
Academic Article Global gene expression changes in rat retinal ganglion cells in experimental glaucoma.
Academic Article Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Academic Article EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane.
Academic Article A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.
Academic Article Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.
Academic Article Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease.
Academic Article Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.
Academic Article Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
Academic Article Abeta associated neuropil changes: correlation with neuronal loss and dementia.
Academic Article Dynamics of plaque formation in Alzheimer's disease.
Academic Article Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
Academic Article In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
Academic Article [Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease].
Academic Article Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids.
Academic Article Neuropathology of Alzheimer's disease.
Academic Article Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.
Academic Article Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice.
Academic Article Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging.
Academic Article Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.
Academic Article A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.
Academic Article In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Academic Article Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.
Academic Article In reply to Zou et al. "New amyloid plaques or a game of hide-and-seek?".
Academic Article Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.
Academic Article A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model.
Academic Article Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease.
Academic Article Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.
Academic Article Aß alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo.
Academic Article Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.
Academic Article Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.
Academic Article gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Academic Article Studying protein degradation pathways in vivo using a cranial window-based approach.
Academic Article The SIST-M: predictive validity of a brief structured clinical dementia rating interview.
Academic Article Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
Academic Article Neuronal structure is altered by amyloid plaques.
Academic Article Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study.
Academic Article Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Academic Article Inhibition of the NFAT pathway alleviates amyloid ß neurotoxicity in a mouse model of Alzheimer's disease.
Academic Article Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease.
Academic Article Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.
Concept Models, Chemical
Concept Models, Molecular
Concept Logistic Models
Concept Linear Models
Concept Disease Models, Animal
Concept Models, Statistical
Concept Models, Neurological
Concept Models, Biological
Concept Proportional Hazards Models
Academic Article Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.
Academic Article Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease.
Academic Article Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.
Academic Article Brain interstitial oligomeric amyloid ß increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.
Academic Article Human LilrB2 is a ß-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Academic Article Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.
Academic Article Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.
Academic Article Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
Academic Article Direct detection of alpha synuclein oligomers in vivo.
Academic Article Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.
Academic Article Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model.
Academic Article Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy.
Academic Article Anti-ApoE antibody given after plaque onset decreases Aß accumulation and improves brain function in a mouse model of Aß amyloidosis.
Academic Article Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease.
Academic Article Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum.
Academic Article Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.
Academic Article A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid ß in the brain in a transgenic model of Alzheimer disease.
Academic Article Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease.
Academic Article Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV.
Academic Article Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-ß plaques.
Academic Article Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
Academic Article Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice.
Academic Article Non-Fibrillar Oligomeric Amyloid-ß within Synapses.
Grant Peripherally administered gene therapy for Alzheimer's
Grant A Model of Early Alzheimer Disease
Grant APOLIPOPROTEIN E AND ALZHEIMERS DISEASE
Grant Anatomical Changes in Tau Transgenic Models
Grant Neurologic Alterations in Alzheimer's Disease
Grant Center for Alzheimer Therapeutic Science: CATS
Grant Massachusetts Alzheimer's Disease Research Center
Grant MGH/MIT MORRIS UDALL CENTER OF EXCELLENCE IN PD RESEARCH
Grant METABOLIC &EXCITOTOXIC CASCADE IN AGING &ALZHEIMERS
Grant Presenilin Biology and the Mechanisms of Alzheimer's Disease
Academic Article Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Academic Article Human tau increases amyloid ß plaque size but not amyloid ß-mediated synapse loss in a novel mouse model of Alzheimer's disease.
Academic Article Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells.
Academic Article Pathogenic PS1 phosphorylation at Ser367.
Academic Article Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease.
Academic Article Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design.
Academic Article Soluble oligomeric amyloid-ß induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.
Academic Article Enhanced Tau Aggregation in the Presence of Amyloid ß.
Academic Article Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome.
Academic Article Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults.
Academic Article Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses.
Academic Article Tau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo.
Academic Article Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery.
Academic Article ß-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals.
Academic Article The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease.
Academic Article Partial reduction of microglia does not affect tau pathology in aged mice.
Academic Article Different tau species lead to heterogeneous tau pathology propagation and misfolding.
Academic Article Tau impairs neural circuits, dominating amyloid-ß effects, in Alzheimer models in vivo.
Grant Are multiple tau species toxic in Alzheimer's Disease?
Academic Article Effects of Species-Specific Genetics on Alzheimer's Mouse Models.
Academic Article Opposing Roles of apolipoprotein E in aging and neurodegeneration.
Academic Article The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aß Plaques.
Grant Liquid liquid phase separation and tau biology
Academic Article Experimental evidence for the age dependence of tau protein spread in the brain.
Grant Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease
Academic Article Synergy between amyloid-ß and tau in Alzheimer's disease.
Academic Article A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.
Grant Synergy between amyloid and tau in Alzheimer's Disease
Grant Are multiple tau species toxic in Alzheimer's Disease?
Grant Novel Strategies and Mechanisms to Target APOE and Alzheimer's Disease
Academic Article Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
Academic Article Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.