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One or more keywords matched the following items that are connected to Hyman, Bradley
Item TypeName
Academic Article BACE is degraded via the lysosomal pathway.
Academic Article alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons.
Academic Article Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
Academic Article Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.
Academic Article Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Academic Article Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism.
Academic Article Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Academic Article Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Academic Article Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
Academic Article Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.
Academic Article Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
Academic Article beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging.
Academic Article The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
Academic Article The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors.
Academic Article The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.
Academic Article Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-ß precursor protein.
Academic Article Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Academic Article Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking.
Academic Article GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
Academic Article Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
Academic Article Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Academic Article Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Academic Article Beta-secretase activity increases with aging in human, monkey, and mouse brain.
Academic Article Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
Academic Article Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Academic Article Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein.
Academic Article Localization of non-N-methyl-D-aspartate glutamate receptors in normal and Alzheimer hippocampal formation.
Academic Article Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
Academic Article Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
Academic Article ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes.
Academic Article The effects of amyloid precursor protein on postsynaptic composition and activity.
Academic Article Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine.
Academic Article Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Academic Article Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology.
Concept Receptors, N-Methyl-D-Aspartate
Concept Aspartic Acid Endopeptidases
Concept Aspartic Acid
Academic Article The Golgi-Localized ?-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-ß Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).
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  • Aspartic Acid
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.