Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Fishman, Jay
PropertyValue
overview This laboratory has focused on the molecular pathogenesis of infections in immunocompromised hosts. We have isolated and cloned the major surface antigens of the fungal pathogen Pneumocystis carinii. We have studied pathogenesis of infections by the porcine endogenous retrovirus and other porcine viruses to prevent infection in future pig-to-human xenotransplantation, as a model for organ-donor-derived infections. The virus (PERV) has been cloned and quantitative assays developed for this potential pathogen. This approach has been used nationally and internationally in the development of guidelines for screening of organ donors in solid organ transplantation and xenotransplantation including the FDA Advisory Panel on Xenotransplantation, guidelines for Harvard Medical School, US Public Health Service, Health Canada, Institute of Medicine, and World Health Organization. Clinical investigation has been an outgrowth of the Transplant Infectious Disease Program. Trials of innovative therapies for Pneumocystis infection (atovaquone) in stem cell and solid organ transplantation and of bioavailability of new antiviral agents (ganciclovir) grew directly out of clinical need for such therapies. More recently, we have developed clinical protocols for the national multicenter Clinical Trials in Organ Transplantation to monitor viral infections using novel mutiplexed viral molecular assays, approaches to antimicrobial prophylaxis (ganciclovir, valganciclovir) and therapy (posaconazole) in immunosuppressed hosts, for the harmonization of laboratory assays for viral infections across multiple assay platforms at multiple clinical centers, and for antibody responses to vaccination following heart and kidney transplantation. We have also participated in animal and human trails of the induction of immune tolerance for organ transplantation.
One or more keywords matched the following items that are connected to Fishman, Jay
Item TypeName
Academic Article Pneumocystis carinii and parasitic infections in transplantation.
Academic Article Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig-to-baboon xenotransplantation.
Academic Article Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients.
Academic Article A consideration of potential donors with active infection--is this a way to expand the donor pool?
Academic Article Infection in xenotransplantation.
Academic Article Cytomegalovirus pneumonia in transplant recipients.
Academic Article Prevention of infection due to Pneumocystis carinii.
Academic Article Postmenopausal tubo-ovarian abscess due to Pseudomonas aeruginosa in a renal transplant patient: a case report and review of the literature.
Academic Article Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry.
Academic Article Infection in organ transplantation: risk factors and evolving patterns of infection.
Academic Article Salvage therapy with voriconazole for invasive fungal infections in patients failing or intolerant to standard antifungal therapy.
Academic Article Treatment of infection due to Pneumocystis carinii.
Academic Article Effect of oral acyclovir or ganciclovir therapy after preemptive intravenous ganciclovir therapy to prevent cytomegalovirus disease in cytomegalovirus seropositive renal and liver transplant recipients receiving antilymphocyte antibody therapy.
Academic Article Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation.
Academic Article Transplantation for patients infected with human immunodeficiency virus: no longer experimental but not yet routine.
Academic Article Pre-screening of miniature swine may reduce the risk of transmitting human tropic recombinant porcine endogenous retroviruses.
Academic Article Systemic Infection, Sepsis Syndrome, and the Lungs
Academic Article Infection in organ-transplant recipients.
Academic Article Quantitation of porcine cytomegalovirus in pig tissues by PCR.
Academic Article Safety and efficacy of granulocyte colony-stimulating factor in kidney and liver transplant recipients.
Academic Article Failure of low-dose atovaquone prophylaxis against Pneumocystis jiroveci infection in transplant recipients.
Academic Article Canadian society of transplantation consensus workshop on cytomegalovirus management in solid organ transplantation final report.
Academic Article Prevention of primary cytomegalovirus disease in organ transplant recipients with oral ganciclovir or oral acyclovir prophylaxis.
Academic Article Solid organ transplantation in HIV-infected individuals: obstacles and opportunities.
Academic Article Prevention of infection in adult travelers after solid organ transplantation.
Academic Article Herpesvirus infections in xenotransplantation: pathogenesis and approaches.
Academic Article Transmission of lymphocytic choriomeningitis virus by organ transplantation.
Academic Article Infection in renal transplant recipients.
Academic Article Effect of thermal injury with Pseudomonas aeruginosa infection on pulmonary and systemic bacterial clearance.
Academic Article Miniature swine as organ donors for man: strategies for prevention of xenotransplant-associated infections
Academic Article HIV Infection and Opportunistic Pulmonary Infections in AIDS
Academic Article Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-2004. A 58-year-old man with acute myeloid leukemia and Fever after chemotherapy.
Academic Article Central nervous system involvement in cryptococcal infection in individuals after solid organ transplantation or with AIDS.
Academic Article Cytomegalovirus in transplantation - challenging the status quo.
Academic Article Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients.
Academic Article Pulmonary Infection in Cancer and Neutropenia
Academic Article Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry.
Academic Article Introduction: infection in solid organ transplant recipients.
Academic Article Prevention of recurrent cytomegalovirus disease in renal and liver transplant recipients: effect of oral ganciclovir.
Academic Article Infections in immunocompromised hosts and organ transplant recipients: essentials.
Academic Article Xenotransplantation-associated infectious risk: a WHO consultation.
Academic Article Dosing of intravenous ganciclovir for the prophylaxis and treatment of cytomegalovirus infection in solid organ transplant recipients.
Academic Article Infection in xenotransplantation.
Academic Article The bidirectional relationship between cytomegalovirus and allograft injury.
Academic Article Combination antiviral therapy for ganciclovir-resistant cytomegalovirus infection in solid-organ transplant recipients.
Academic Article BK virus nephropathy--polyomavirus adding insult to injury.
Academic Article Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice.
Academic Article Prevention of CMV infection in transplant patients
Academic Article Opportunistic Infections. A. Bahn, R. Colvin, R. McClusky, ed
Academic Article Pulmonary imaging of pandemic influenza H1N1 infection: relationship between clinical presentation and disease burden on chest radiography and CT.
Academic Article An approach to pulmonary infections in AIDS
Academic Article Systemic Infections and the Lungs
Academic Article Donor-derived infection: old problem, new solutions?
Academic Article Long life with or without PERV.
Academic Article Disseminated Mycobacterium kansasii infection with hepatic abscesses in a renal transplant recipient.
Academic Article Retroviral restriction factors and infectious risk in xenotransplantation.
Academic Article Infection and T-lymphocyte subpopulations; changes associated with bacteremia and the acquired immunodeficiency syndrome
Academic Article Donor-derived infections in solid organ transplant recipients.
Academic Article Infections and organ transplantation: new challenges for prevention and treatment--a colloquium.
Academic Article Radiologic approaches to Pneumocystis carinii infection
Academic Article Xenosis and xenotransplantation: addressing the infectious risks posed by an emerging technology.
Academic Article BK virus in solid organ transplant recipients: an emerging syndrome.
Academic Article Listeria monocytogenes infection in caspase-11-deficient mice.
Academic Article BK nephropathy: what is the role of antiviral therapy?
Academic Article Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trial.
Academic Article Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus.
Academic Article Fungal Infection in the Organ Transplant Recipient; Challenges and Opportunities
Academic Article Uncertainty in xenotransplantation: individual benefit versus collective risk.
Academic Article Activation of cytomegalovirus in pig-to-primate organ xenotransplantation.
Academic Article Infection and T lymphocyte subpopulations: changes associated with bacteremia and the acquired immunodeficiency syndrome.
Academic Article Infection and xenotransplantation. Developing strategies to minimize risk.
Academic Article Infection in xenotransplantation: a clinical approach.
Academic Article Infection in solid-organ transplant recipients.
Academic Article Prevention of CMV infection in transplant patients.
Academic Article Activation of porcine cytomegalovirus, but not porcine lymphotropic herpesvirus, in pig-to-baboon xenotransplantation.
Academic Article Pulmonary Infections in Transplantation
Academic Article An approach to pulmonary infection in AIDS.
Academic Article Pneumocystis carinii and parasitic infections in the Immunocompromised Host in Clinical Approaches to Infections in the Compromised Host. R. Rubin, L. Young, ed
Academic Article How should we evaluate organ donors with active or prior infections?
Academic Article Overview: fungal infections in the transplant patient.
Academic Article Vancomycin-resistant Enterococcus in liver transplantation: what have we left behind?
Academic Article Overview: cytomegalovirus and the herpesviruses in transplantation.
Academic Article Pneumocystis carinii and parasitic infections in transplantation
Academic Article Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients.
Academic Article Fungal Infection in the Organ Transplant Recipient; Challenges and Opportunities
Academic Article Primary infection with cytomegalovirus in ulcerative colitis.
Academic Article Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model.
Academic Article Infectious complications of antilymphocyte therapies in solid organ transplantation.
Academic Article Pandemic Swine flu 2009.
Academic Article Overview: Pulmonary Infection in Special Hosts
Academic Article Xenotransplantation: infectious risk revisited.
Academic Article Viral infection in the renal transplant recipient.
Academic Article NK cells, innate immunity and hepatitis C infection after liver transplantation.
Academic Article Prophylaxis, preemption and drug resistance in CMV infection: too little, too much or just right?
Academic Article Transmission of infection with human allografts: essential considerations in donor screening.
Academic Article Human immunodeficiency virus type 1 infection of human macrophages modulates the cytokine response to Pneumocystis carinii.
Academic Article Preventing Infection in Xenotransplantation: Xenosis from miniature swine
Academic Article New rat model of Pneumocystis carinii infection.
Academic Article Asymptomatic cryptococcal infection in solid organ transplant recipients
Academic Article Protozoan Infection of the Lung (Pneumocystis)
Academic Article Prevention of infection caused by Pneumocystis carinii in transplant recipients.
Academic Article The risk of infection in xenotransplantation. Introduction.
Academic Article Smallpox and live-virus vaccination in transplant recipients.
Academic Article Presentation of the PATH Alliance registry for prospective data collection and analysis of the epidemiology, therapy, and outcomes of invasive fungal infections.
Academic Article Transplantation microbiology: an evolving pillar of transplant care.
Academic Article Viral infection induces de novo lesions of coronary allograft vasculopathy through a natural killer cell-dependent pathway.
Academic Article Use of induced sputum specimens for microbiologic diagnosis of infections due to organisms other than Pneumocystis carinii.
Concept Wound Infection
Concept Klebsiella Infections
Concept Cytomegalovirus Infections
Concept Bacterial Infections
Concept Streptococcal Infections
Concept Gram-Positive Bacterial Infections
Concept Opportunistic Infections
Concept Pneumocystis Infections
Concept Herpesviridae Infections
Concept Central Nervous System Infections
Concept Mycobacterium Infections
Concept Retroviridae Infections
Concept Tumor Virus Infections
Concept HIV Infections
Concept Polyomavirus Infections
Concept Epstein-Barr Virus Infections
Concept Coronavirus Infections
Concept AIDS-Related Opportunistic Infections
Concept Infection Control
Concept Protozoan Infections
Concept Cross Infection
Concept Arenaviridae Infections
Concept Staphylococcal Infections
Concept Orthomyxoviridae Infections
Concept Central Nervous System Fungal Infections
Concept Pneumococcal Infections
Concept Pseudomonas Infections
Academic Article Opportunistic infections--coming to the limits of immunosuppression?
Academic Article Assessment of infectious risk in clinical xenotransplantation: the lessons for clinical allotransplantation.
Academic Article From the classic concepts to modern practice.
Academic Article Central nervous system syndromes in solid organ transplant recipients.
Academic Article Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model.
Academic Article Results of life-supporting galactosyltransferase knockout kidneys in cynomolgus monkeys using two different sources of galactosyltransferase knockout Swine.
Academic Article Reply to Antinori et al.
Academic Article Donor-derived infection--the challenge for transplant safety.
Academic Article Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards.
Academic Article Genome-wide inactivation of porcine endogenous retroviruses (PERVs).
Academic Article The Cell Biology of Cytomegalovirus: Implications for Transplantation.
Grant ALVEOLAR MACROPHAGE RESPONSE TO MYCOBACTERIAL CELL WALL
Academic Article Zika Virus in Transplantation: Emerging Infection and Opportunities.
Academic Article Infection in Organ Transplantation.
Academic Article Discrepant serological assays for Pneumococcus in renal transplant recipients - a prospective study.
Academic Article Utilization of increased risk for transmission of infectious disease donor organs in solid organ transplantation: Retrospective analysis of disease transmission and safety.
Academic Article Infectious disease risks in xenotransplantation.
Academic Article Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig-to-baboon renal xenotransplantation in vivo.
Academic Article Donor-derived infections and infectious risk in xenotransplantation and allotransplantation.
Academic Article Infection in xenotransplantation: opportunities and challenges.
Academic Article The Immunocompromised Transplant Recipient and SARS-CoV-2 Infection.
Academic Article Prevention of infection in xenotransplantation: Designated pathogen-free swine in the safety equation.
Search Criteria
  • Infection
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.