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One or more keywords matched the following items that are connected to Tsokos, George
Item TypeName
Academic Article Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration.
Academic Article Molecular aspects in the pathogenesis of human systemic lupus erythematosus.
Academic Article The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells.
Academic Article Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation.
Academic Article Dissecting the molecular mechanisms of TCR zeta chain downregulation and T cell signaling abnormalities in human systemic lupus erythematosus.
Academic Article TCR zeta-chain abnormalities in human systemic lupus erythematosus.
Academic Article Heat stress downregulates TCR zeta chain expression in human T lymphocytes.
Academic Article Systemic lupus erythematosus: new molecular targets.
Academic Article Systemic lupus erythematosus. A disease with a complex pathogenesis.
Academic Article Immune cell signaling defects in lupus: activation, anergy and death.
Academic Article Emerging concepts in the molecular pathogenesis of systemic lupus erythematosus.
Academic Article T cell rewiring in differentiation and disease.
Academic Article Abnormal T lymphocyte signal transduction in systemic lupus erythematosus.
Academic Article NF-kappaB regulates the expression of the human complement receptor 2 gene.
Academic Article Immune cell signaling in lupus.
Academic Article SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells.
Academic Article T-cell signaling abnormalities in human systemic lupus erythematosus.
Academic Article Autoimmunity in systemic lupus erythematosus: integrating genes and biology.
Academic Article Transcriptional regulation of IL-2 in health and autoimmunity.
Academic Article Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus.
Academic Article Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling.
Academic Article T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho.
Academic Article T cells as therapeutic targets in SLE.
Academic Article Immune cell biochemical abnormalities in systemic lupus erythematosus.
Academic Article Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.
Academic Article Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription.
Academic Article Abnormal T cell signal transduction in systemic lupus erythematosus.
Academic Article Abnormal B cell signal transduction in systemic lupus erythematosus.
Academic Article Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function.
Academic Article Altered signal transduction in SLE T cells.
Academic Article Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity.
Academic Article T lymphocytes in systemic lupus erythematosus: an update.
Academic Article cAMP responsive element modulator: a critical regulator of cytokine production.
Academic Article How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype.
Academic Article Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus.
Academic Article Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway.
Academic Article B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.
Academic Article Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells.
Academic Article Immune cell signaling aberrations in human lupus.
Academic Article Molecular aberrations in human systemic lupus erythematosus.
Academic Article T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA.
Academic Article Effects of an aminosteroid inhibitor of phospholipase C-dependent processes on the TCR-mediated signal transduction pathway in human T cells.
Academic Article Abnormal early TCR/CD3-mediated signaling events of a snRNP-autoreactive lupus T cell clone.
Academic Article B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE).
Academic Article Fas (CD95) ligation inhibits activation of NF-kappa B by targeting p65-Rel A in a caspase-dependent manner.
Academic Article Proximal signaling control of human effector CD4 T cell function.
Academic Article Abnormalities of T cell signaling in systemic lupus erythematosus.
Academic Article Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase.
Academic Article High dose of dexamethasone upregulates TCR/CD3-induced calcium response independent of TCR zeta chain expression in human T lymphocytes.
Academic Article Methods and protocols to study T cell signaling abnormalities in human systemic lupus erythematosus.
Academic Article Immune cell signaling and gene transcription in human lupus: the time has come.
Academic Article Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases.
Academic Article Cross-linking of the Fas/APO-1 antigen suppresses the CD3-mediated signal transduction events in human T lymphocytes.
Academic Article The alter ego of heat shock proteins.
Academic Article TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.
Academic Article Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus.
Academic Article Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus.
Academic Article Downregulation of interleukin-2 and apha-chain interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes.
Academic Article CREMa suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells.
Academic Article Syk kinase as a treatment target for therapy in autoimmune diseases.
Concept Signal Transduction
Academic Article The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients.
Academic Article Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling.
Academic Article The role of T cells in systemic lupus erythematosus: an update.
Academic Article T cells as a therapeutic target in SLE.
Academic Article Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3? in Human T Cells.
Academic Article Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.
Academic Article Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue damage and fibrosis in a bleomycin-induced scleroderma mouse model.
Academic Article N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome.
Academic Article Phosphatase PP2A is requisite for the function of regulatory T cells.
Academic Article Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production.
Academic Article T cells in Systemic Lupus Erythematosus.
Academic Article Pin1-Targeted Therapy for Systemic Lupus Erythematosus.
Academic Article New insights into the immunopathogenesis of systemic lupus erythematosus.
Academic Article Immune cell signaling in autoimmune diseases.
Academic Article Microglia-dependent synapse loss in type I interferon-mediated lupus.
Academic Article Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.
Academic Article SLE-Associated Defects Promote Altered T Cell Function.
Academic Article Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
Academic Article CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Academic Article PP2A enables IL-2 signaling by preserving IL-2Rß chain expression during Treg development.
Academic Article CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells.
Academic Article Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity.
Academic Article Notch notches lupus.
Academic Article IL-23/IL-17 Axis in Inflammatory Rheumatic Diseases.
Academic Article Current insights and future prospects for the pathogenesis and treatment for rheumatoid arthritis.
Academic Article The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway.
Search Criteria
  • Pathway Signal Transduction
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.