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One or more keywords matched the following items that are connected to Tsokos, George
Item TypeName
Academic Article Lymphocytes, cytokines, inflammation, and immune trafficking.
Academic Article Transcriptional repression of interleukin-2 in human systemic lupus erythematosus.
Academic Article Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes.
Academic Article Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation.
Academic Article cAMP-responsive element modulator (CREM)a protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus.
Academic Article A novel isoform of the orphan receptor ROR?t suppresses IL-17 production in human T cells.
Academic Article Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE.
Academic Article Systemic lupus erythematosus: new molecular targets.
Academic Article Transcriptional regulation of interleukin 2 in SLE T cells.
Academic Article Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.
Academic Article Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus.
Academic Article Abnormal T lymphocyte signal transduction in systemic lupus erythematosus.
Academic Article Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity.
Academic Article Transcriptional regulation of IL-2 in health and autoimmunity.
Academic Article Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus.
Academic Article Kinetics of interleukin-4 induction and interferon-gamma inhibition of IgE secretion by Epstein-Barr virus-infected human peripheral blood B cells.
Academic Article Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling.
Academic Article Interleukin-2 in systemic autoimmunity hits the micro way.
Academic Article Interleukin-17 and systemic lupus erythematosus: current concepts.
Academic Article Interleukin-2 restores the depressed allogeneic cell-mediated lympholysis and natural killer cell activity in patients with systemic lupus erythematosus.
Academic Article T cell-antigen-presenting cell interactions in human systemic lupus erythematosus. Evidence for heterogeneous expression of multiple defects.
Academic Article CAMP response element modulator a expression in patients with systemic lupus erythematosus.
Academic Article IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice.
Academic Article Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription.
Academic Article Increased levels of intercellular adhesion molecule-1 in the serum of patients with systemic lupus erythematosus.
Academic Article Soluble interleukin-2 receptor is a thyroid hormone-dependent early-response marker in the treatment of thyrotoxicosis.
Academic Article Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.
Academic Article The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism.
Academic Article Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups.
Academic Article Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism.
Academic Article Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders.
Academic Article Altered signal transduction in SLE T cells.
Academic Article Deficient gamma-interferon production in patients with systemic lupus erythematosus.
Academic Article Interleukin-17-producing T cells in lupus.
Academic Article Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity.
Academic Article Elevated soluble CD8 antigen and soluble interleukin-2 receptors in the sera of patients with juvenile rheumatoid arthritis.
Academic Article Effects of cholera toxin on human B cells. Cholera toxin induces B cell surface DR expression while it inhibits anti-mu antibody-induced cell proliferation.
Academic Article Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys.
Academic Article IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.
Academic Article The role of IL-23/IL-17 axis in lupus nephritis.
Academic Article cAMP response element modulator a controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.
Academic Article Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis.
Academic Article Estrogen upregulates cyclic AMP response element modulator a expression and downregulates interleukin-2 production by human T lymphocytes.
Academic Article cAMP-responsive element modulator a (CREMa) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).
Academic Article Cholera toxin promotes the proliferation of anti-mu antibody-prestimulated human B cells.
Academic Article Effects of an aminosteroid inhibitor of phospholipase C-dependent processes on the TCR-mediated signal transduction pathway in human T cells.
Academic Article Multiple transcription factors regulate the inducible expression of the human complement receptor 2 promoter.
Academic Article The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity.
Academic Article Autoimmunity, complement activation, tissue injury and reciprocal effects.
Academic Article cAMP-responsive element modulator a (CREMa) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).
Academic Article Immunoregulatory disorders associated with hereditary angioedema. II. Serologic and cellular abnormalities.
Academic Article B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE).
Academic Article Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.
Academic Article Treatment of systemic lupus erythematosus: new advances in targeted therapy.
Academic Article Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.
Academic Article Defective CD3zeta chain expression in Herpesvirus saimiri (HVS)-derived T-cell lines in gastric adenocarcinoma.
Academic Article Oxidative stress is involved in the heat stress-induced downregulation of TCR zeta chain expression and TCR/CD3-mediated [Ca(2+)](i) response in human T-lymphocytes.
Academic Article Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus.
Academic Article Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta.
Academic Article Immune cell signaling and gene transcription in human lupus: the time has come.
Academic Article The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity.
Academic Article Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin.
Academic Article Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells.
Academic Article Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice.
Academic Article Decay-accelerating factor attenuates C-reactive protein-potentiated tissue injury after mesenteric ischemia/reperfusion.
Academic Article CREMa overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.
Academic Article CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances ROR?t recruitment to the IL17A promoter in human T lymphocytes.
Academic Article Regulation of human cytotoxic responses by complement: C3, C3b and C3d preparations enhance human allogeneic cytotoxic responses.
Academic Article Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription.
Academic Article Defective antigen-presenting cell function in patients with systemic lupus erythematosus.
Academic Article Pathophysiologic aspects of lymphokines.
Academic Article IL-17 in systemic lupus erythematosus.
Academic Article Downregulation of interleukin-2 and apha-chain interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes.
Academic Article IL-17-producing T cells in lupus nephritis.
Academic Article cAMP-responsive element modulator (CREM)a protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.
Academic Article Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
Academic Article Antisense cyclic adenosine 5'-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus.
Academic Article Human in vitro allogeneic responses. Demonstration of three pathways of T helper cell activation.
Academic Article Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus.
Academic Article Induction of PP2A Bß, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus.
Concept Receptors, Interleukin
Concept Interleukin-2 Receptor alpha Subunit
Concept Interleukin-12
Concept Interleukin-1 Receptor-Associated Kinases
Concept Receptors, Interleukin-2
Concept Interleukin-17
Concept Interleukin-4
Concept Interleukin-23
Concept Interleukin-6
Concept Interleukin-10
Concept Interleukins
Concept Interleukin-2 Receptor beta Subunit
Concept Interleukin-1
Concept Interleukin-2
Concept Interleukin-3
Academic Article Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone mice.
Academic Article Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling.
Academic Article Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.
Academic Article A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus.
Academic Article CaMK4-dependent activation of AKT/mTOR and CREM-a underlies autoimmunity-associated Th17 imbalance.
Academic Article IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.
Academic Article KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3? regulatory T cells in MRL/lpr mice.
Academic Article Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling.
Academic Article T cells as a therapeutic target in SLE.
Academic Article Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.
Academic Article Systemic lupus erythematosus in 2015: Cellular and metabolic requirements of effector T cells.
Academic Article Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production.
Academic Article Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases.
Academic Article Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.
Grant Expanded Double Negative T cells in SLE
Grant Gene Transcription In SLE
Academic Article Pin1-Targeted Therapy for Systemic Lupus Erythematosus.
Academic Article Low-Dose IL-2 in the Treatment of Lupus.
Academic Article T cells and IL-17 in lupus nephritis.
Academic Article Brief Report: CD4+ T Cells From Patients With Systemic Lupus Erythematosus Respond Poorly to Exogenous Interleukin-2.
Academic Article Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.
Academic Article IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus.
Academic Article The serine/threonine protein phosphatase 2A controls autoimmunity.
Academic Article IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.
Academic Article Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.
Academic Article Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus.
Academic Article Decreased Expression of Serine/Arginine-Rich Splicing Factor 1 in T Cells From Patients With Active Systemic Lupus Erythematosus Accounts for Reduced Expression of RasGRP1 and DNA Methyltransferase 1.
Academic Article Signaling Lymphocytic Activation Molecule Family Member 1 Engagement Inhibits T Cell-B Cell Interaction and Diminishes Interleukin-6 Production and Plasmablast Differentiation in Systemic Lupus Erythematosus.
Academic Article Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study.
Academic Article Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.
Grant Phosphatases in Systemic Autoimmunity
Academic Article The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target.
Academic Article PP2A enables IL-2 signaling by preserving IL-2Rß chain expression during Treg development.
Academic Article CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells.
Academic Article Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells.
Search Criteria
  • Interleukins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.