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One or more keywords matched the following items that are connected to Tsokos, George
Item TypeName
Academic Article N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells.
Academic Article Association of deficient type II protein kinase A activity with aberrant nuclear translocation of the RII beta subunit in systemic lupus erythematosus T lymphocytes.
Academic Article The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells.
Academic Article Cytoprotection and regulation of heat shock proteins induced by heat shock in human breast cancer T47-D cells: role of [Ca2+]i and protein kinases.
Academic Article Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes.
Academic Article Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation.
Academic Article Characterization of distinct heat shock- and thapsigargin-induced cytoprotective proteins in FRTL-5 thyroid cells.
Academic Article Abnormal T lymphocyte signal transduction in systemic lupus erythematosus.
Academic Article Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain.
Academic Article 17 beta-estradiol-induced increases in glucose-regulated protein 78kD and 94kD protect human breast cancer T47-D cells from thermal injury.
Academic Article Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells.
Academic Article Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice.
Academic Article c-Jun and Ets2 proteins regulate expression of spleen tyrosine kinase in T cells.
Academic Article Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases.
Academic Article ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.
Academic Article Altered signal transduction in SLE T cells.
Academic Article Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV.
Academic Article Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production.
Academic Article Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus.
Academic Article Clinical significance of low creatine phosphokinase values in patients with connective tissue diseases.
Academic Article Effects of an aminosteroid inhibitor of phospholipase C-dependent processes on the TCR-mediated signal transduction pathway in human T cells.
Academic Article Overexpression of HSP-70 inhibits the phosphorylation of HSF1 by activating protein phosphatase and inhibiting protein kinase C activity.
Academic Article Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion.
Academic Article FcRgamma chain does not replace CD3zeta chain in CD3zeta-deficient T lymphocytes of patients with gastric adenocarcinoma.
Academic Article Proximal signaling control of human effector CD4 T cell function.
Academic Article Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.
Academic Article Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase.
Academic Article Dexamethasone modulates TCR zeta chain expression and antigen receptor-mediated early signaling events in human T lymphocytes.
Academic Article Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta.
Academic Article Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases.
Academic Article Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury.
Academic Article Biochemical requirements for the expression of heat shock protein 72 kda in human breast cancer MCF-7 cells.
Academic Article Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus.
Academic Article Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells.
Academic Article CREMa suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells.
Academic Article Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.
Academic Article Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells.
Academic Article Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion.
Academic Article Syk kinase as a treatment target for therapy in autoimmune diseases.
Concept Mitogen-Activated Protein Kinase Phosphatases
Concept Creatine Kinase
Concept Janus Kinase 3
Concept Protein Kinase Inhibitors
Concept Cyclic AMP-Dependent Protein Kinase Type II
Concept Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
Concept Glycogen Synthase Kinase 3
Concept ZAP-70 Protein-Tyrosine Kinase
Concept MAP Kinase Signaling System
Concept Protein Kinase C
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 4
Concept Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
Academic Article The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients.
Academic Article Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling.
Academic Article CaMK4-dependent activation of AKT/mTOR and CREM-a underlies autoimmunity-associated Th17 imbalance.
Academic Article KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3? regulatory T cells in MRL/lpr mice.
Academic Article Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue damage and fibrosis in a bleomycin-induced scleroderma mouse model.
Academic Article Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.
Academic Article Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
Academic Article Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
Academic Article Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases.
Grant Targeting CaMK4 in SLE
Grant Gene Transcription In SLE
Academic Article Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.
Academic Article CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
Academic Article Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.
Academic Article CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells.
Academic Article Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
Academic Article TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.
Academic Article cAMP Response Element Modulator a Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.
Academic Article N-glycosylated IgG in patients with kidney transplants increases calcium/calmodulin kinase IV in podocytes and causes injury.
Academic Article IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation.
Academic Article Complement activation and increased expression of Syk, mucin-1 and CaMK4 in kidneys of patients with COVID-19.
Search Criteria
  • Elongation Factor 2 Kinase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.