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One or more keywords matched the following items that are connected to Gygi, Steven
Item TypeName
Academic Article Characterization of mouse spleen cells by subtractive proteomics.
Academic Article Optimization and use of peptide mass measurement accuracy in shotgun proteomics.
Academic Article Phosphoproteome analysis of Drosophila melanogaster embryos.
Academic Article SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Academic Article Gas-phase rearrangements do not affect site localization reliability in phosphoproteomics data sets.
Academic Article Proteomics: the move to mixtures.
Academic Article The effects of mass accuracy, data acquisition speed, and search algorithm choice on peptide identification rates in phosphoproteomics.
Academic Article Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae.
Academic Article Intensity-based protein identification by machine learning from a library of tandem mass spectra.
Academic Article Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Academic Article BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Academic Article The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications.
Academic Article Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics.
Academic Article Large-scale phosphorylation analysis of mouse liver.
Academic Article A proteomics approach to understanding protein ubiquitination.
Academic Article Phosphoproteomic analysis of the developing mouse brain.
Academic Article A proteomic strategy for gaining insights into protein sumoylation in yeast.
Academic Article Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
Academic Article Signaling networks assembled by oncogenic EGFR and c-Met.
Academic Article Network organization of the human autophagy system.
Academic Article A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells.
Academic Article Assigning spectrum-specific P-values to protein identifications by mass spectrometry.
Academic Article Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen.
Academic Article A tissue-specific atlas of mouse protein phosphorylation and expression.
Academic Article Correct interpretation of comprehensive phosphorylation dynamics requires normalization by protein expression changes.
Academic Article An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
Academic Article Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations.
Academic Article Cellular spelunking: exploring adipocyte caveolae.
Academic Article SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.
Academic Article Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.
Academic Article Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research.
Academic Article Protein profiling with cleavable isotope-coded affinity tag (cICAT) reagents: the yeast salinity stress response.
Academic Article Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon.
Academic Article The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses.
Academic Article Hyperplexing: a method for higher-order multiplexed quantitative proteomics provides a map of the dynamic response to rapamycin in yeast.
Academic Article Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.
Academic Article The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126.
Academic Article Identification of FBXO25-interacting proteins using an integrated proteomics approach.
Academic Article MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics.
Academic Article Proteomic insights into ubiquitin and ubiquitin-like proteins.
Academic Article Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
Academic Article The impact of microRNAs on protein output.
Academic Article Catch-and-release reagents for broadscale quantitative proteomics analyses.
Academic Article A solid phase extraction-based platform for rapid phosphoproteomic analysis.
Academic Article Mass spectrometry and proteomics.
Academic Article Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry.
Academic Article Evaluation of HCD- and CID-type fragmentation within their respective detection platforms for murine phosphoproteomics.
Academic Article A protein complex network of Drosophila melanogaster.
Academic Article A quantitative atlas of mitotic phosphorylation.
Academic Article Defining the human deubiquitinating enzyme interaction landscape.
Academic Article Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling.
Academic Article Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster.
Academic Article A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.
Academic Article Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS.
Academic Article Systematic and quantitative assessment of the ubiquitin-modified proteome.
Academic Article Assessing enzyme activities using stable isotope labeling and mass spectrometry.
Academic Article SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans.
Academic Article Target-decoy search strategy for mass spectrometry-based proteomics.
Academic Article A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.
Academic Article Network-based inference from complex proteomic mixtures using SNIPE.
Academic Article A comparative proteomic analysis of human and rat embryonic cerebrospinal fluid.
Academic Article Evaluation of the utility of neutral-loss-dependent MS3 strategies in large-scale phosphorylation analysis.
Academic Article Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia.
Concept Proteomics
Academic Article Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation.
Academic Article Increasing throughput in targeted proteomics assays: 54-plex quantitation in a single mass spectrometry run.
Academic Article Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Academic Article The influence of signals from chilled roots on the proteome of shoot tissues in rice seedlings.
Academic Article Heterochromatic gene silencing by activator interference and a transcription elongation barrier.
Academic Article Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Academic Article TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.
Academic Article Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation.
Academic Article Combining amine metabolomics and quantitative proteomics of cancer cells using derivatization with isobaric tags.
Academic Article PP2ARts1 is a master regulator of pathways that control cell size.
Academic Article Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.
Academic Article Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.
Academic Article Quantitative temporal viromics: an approach to investigate host-pathogen interaction.
Academic Article MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes.
Academic Article Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database.
Academic Article Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast.
Academic Article Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos.
Academic Article Large-scale proteomic characterization of melanoma expressed proteins reveals nestin and vimentin as biomarkers that can potentially distinguish melanoma subtypes.
Academic Article Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Academic Article Quantitative Proteomics Reveal a Feedforward Model for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis.
Academic Article Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins.
Academic Article A comprehensive proteomic and phosphoproteomic analysis of yeast deletion mutants of 14-3-3 orthologs and associated effects of rapamycin.
Academic Article Proteomic Profiling of Paclitaxel Treated Cells Identifies a Novel Mechanism of Drug Resistance Mediated by PDCD4.
Academic Article QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.
Academic Article Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics.
Academic Article Evaluating multiplexed quantitative phosphopeptide analysis on a hybrid quadrupole mass filter/linear ion trap/orbitrap mass spectrometer.
Academic Article A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides.
Academic Article The BioPlex Network: A Systematic Exploration of the Human Interactome.
Academic Article Erratum: A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides.
Academic Article Comprehensive Temporal Protein Dynamics during the Diauxic Shift in Saccharomyces cerevisiae.
Academic Article Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.
Academic Article Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics.
Academic Article Proteome-wide quantitative multiplexed profiling of protein expression: carbon-source dependency in Saccharomyces cerevisiae.
Academic Article Proteomics of Primary Cilia by Proximity Labeling.
Academic Article Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains.
Academic Article Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response.
Academic Article Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.
Academic Article Blood biomarkers in a mouse model of CADASIL.
Academic Article Defining the consequences of genetic variation on a proteome-wide scale.
Academic Article Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.
Grant Functional Genomics of the Mitochondrial Proteome
Grant New and Disruptive Technologies to Study Ubiquitin Biology through Sample Multiplexing
Grant Systematic Exploration of the Human Interactome
Academic Article A Triple Knockout (TKO) Proteomics Standard for Diagnosing Ion Interference in Isobaric Labeling Experiments.
Academic Article Quantitative mass spectrometry-based multiplexing compares the abundance of 5000 S. cerevisiae proteins across 10 carbon sources.
Academic Article Nicotine-induced protein expression profiling reveals mutually altered proteins across four human cell lines.
Academic Article A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature Characterization.
Academic Article Multiplexed Phosphoproteomic Profiling Using Titanium Dioxide and Immunoaffinity Enrichments Reveals Complementary Phosphorylation Events.
Academic Article Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.
Academic Article Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2).
Academic Article Proteome-Wide Protein Expression Profiling Across Five Pancreatic Cell Lines.
Academic Article A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells.
Academic Article Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.
Academic Article ERRa Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1a-Elevated Melanomas.
Academic Article Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.
Academic Article Quantitative Phospho-proteomic Analysis of TNFa/NF?B Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death.
Academic Article Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism.
Academic Article UBE2O remodels the proteome during terminal erythroid differentiation.
Academic Article Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.
Academic Article Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages.
Grant Proteomics of Cell Signaling in Embryogenesis.
Academic Article Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.
Academic Article Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.
Academic Article Improved Method for Determining Absolute Phosphorylation Stoichiometry Using Bayesian Statistics and Isobaric Labeling.
Academic Article Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg.
Academic Article Compositional Proteomics: Effects of Spatial Constraints on Protein Quantification Utilizing Isobaric Tags.
Academic Article Multiplexed Isobaric Tag-Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy.
Academic Article Proteome-Wide Evaluation of Two Common Protein Quantification Methods.
Academic Article Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.
Academic Article Isobaric Tag-Based Protein Profiling of a Nicotine-Treated Alpha7 Nicotinic Receptor-Null Human Haploid Cell Line.
Academic Article A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.
Academic Article Apolipoprotein E is a pancreatic extracellular factor that maintains mature ß-cell gene expression.
Academic Article Proteomic profiling of yeast heterochromatin connects direct physical and genetic interactions.
Academic Article Web-Based Search Tool for Visualizing Instrument Performance Using the Triple Knockout (TKO) Proteome Standard.
Academic Article TKO6: A Peptide Standard To Assess Interference for Unit-Resolved Isobaric Labeling Platforms.
Academic Article The effects of nonignorable missing data on label-free mass spectrometry proteomics experiments.
Academic Article Active Instrument Engagement Combined with a Real-Time Database Search for Improved Performance of Sample Multiplexing Workflows.
Academic Article TomahaqCompanion: A Tool for the Creation and Analysis of Isobaric Label Based Multiplexed Targeted Assays.
Academic Article Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation.
Academic Article Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity.
Academic Article Therapy-Induced MHC I Ligands Shape Neo-Antitumor CD8 T Cell Responses during Oncolytic Virus-Based Cancer Immunotherapy.
Academic Article Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Academic Article Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance.
Academic Article Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics.
Academic Article Quantitative Proteomics of the Cancer Cell Line Encyclopedia.
Academic Article Full-Featured, Real-Time Database Searching Platform Enables Fast and Accurate Multiplexed Quantitative Proteomics.
Academic Article Benchmarking the Orbitrap Tribrid Eclipse for Next Generation Multiplexed Proteomics.
Academic Article Sample multiplexing for targeted pathway proteomics in aging mice.
Academic Article The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint.
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  • Proteomics
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.