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One or more keywords matched the following items that are connected to Gygi, Steven
Item TypeName
Academic Article Quantitative analysis of complex protein mixtures using isotope-coded affinity tags.
Academic Article Mass spectrometric analysis of the editosome and other multiprotein complexes in Trypanosoma brucei.
Academic Article An integrated microfluidics-tandem mass spectrometry system for automated protein analysis.
Academic Article Phosphoproteome analysis of Drosophila melanogaster embryos.
Academic Article Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae.
Academic Article GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.
Academic Article SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Academic Article Gas-phase rearrangements do not affect site localization reliability in phosphoproteomics data sets.
Academic Article Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column.
Academic Article Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.
Academic Article Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Academic Article Electrophoresis combined with novel mass spectrometry techniques: powerful tools for the analysis of proteins and proteomes.
Academic Article Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS.
Academic Article Intensity-based protein identification by machine learning from a library of tandem mass spectra.
Academic Article Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.
Academic Article Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.
Academic Article Four related proteins of the Trypanosoma brucei RNA editing complex.
Academic Article The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8.
Academic Article Cdc28-dependent regulation of the Cdc5/Polo kinase.
Academic Article Structural organization of distinct domains within the non-collagenous N-terminal region of collagen type XI.
Academic Article Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
Academic Article Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase.
Academic Article Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.
Academic Article A molecular determinant for the establishment of sister chromatid cohesion.
Academic Article Large-scale phosphorylation analysis of mouse liver.
Academic Article Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis.
Academic Article The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.
Academic Article An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
Academic Article A proteomics approach to understanding protein ubiquitination.
Academic Article Identification of 14-3-3epsilon substrates from embryonic murine brain.
Academic Article Phosphoproteomic analysis of the developing mouse brain.
Academic Article A proteomic strategy for gaining insights into protein sumoylation in yeast.
Academic Article Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology.
Academic Article Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Academic Article Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.
Academic Article Phosphorylation controls autoinhibition of cytoplasmic linker protein-170.
Academic Article Correct interpretation of comprehensive phosphorylation dynamics requires normalization by protein expression changes.
Academic Article CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.
Academic Article Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry.
Academic Article SKAR is a specific target of S6 kinase 1 in cell growth control.
Academic Article PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity.
Academic Article Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.
Academic Article Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research.
Academic Article Protein profiling with cleavable isotope-coded affinity tag (cICAT) reagents: the yeast salinity stress response.
Academic Article A stress-responsive system for mitochondrial protein degradation.
Academic Article In situ observation of protein phosphorylation by high-resolution NMR spectroscopy.
Academic Article Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Academic Article The septins function in G1 pathways that influence the pattern of cell growth in budding yeast.
Academic Article p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.
Academic Article S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription.
Academic Article The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126.
Academic Article MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes.
Academic Article Identification of FBXO25-interacting proteins using an integrated proteomics approach.
Academic Article Cdc7-Dbf4 is a gene-specific regulator of meiotic transcription in yeast.
Academic Article Quantitative proteome analysis: methods and applications.
Academic Article Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog.
Academic Article A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Academic Article Protein analysis by mass spectrometry and sequence database searching: tools for cancer research in the post-genomic era.
Academic Article Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Academic Article Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
Academic Article Association of two novel proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA editing complex.
Academic Article HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.
Academic Article Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
Academic Article Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Academic Article Catch-and-release reagents for broadscale quantitative proteomics analyses.
Academic Article The tumor suppressor CYLD regulates entry into mitosis.
Academic Article Regulation of monoubiquitinated PCNA by DUB autocleavage.
Academic Article Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.
Academic Article Methylation by Set9 modulates FoxO3 stability and transcriptional activity.
Academic Article Purification and architecture of the ubiquitous Wave complex.
Academic Article Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry.
Academic Article Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradation.
Academic Article Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase.
Academic Article Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Academic Article Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.
Academic Article A quantitative atlas of mitotic phosphorylation.
Academic Article The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).
Academic Article Mapping and analysis of phosphorylation sites: a quick guide for cell biologists.
Academic Article Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
Academic Article SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
Academic Article Large-scale characterization of HeLa cell nuclear phosphoproteins.
Academic Article Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS.
Academic Article Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Academic Article RNAi-mediated targeting of heterochromatin by the RITS complex.
Academic Article SILVER helps assign peptides to tandem mass spectra using intensity-based scoring.
Academic Article Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.
Academic Article Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.
Academic Article Assessing enzyme activities using stable isotope labeling and mass spectrometry.
Academic Article SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Academic Article A high-throughput, multiplexed kinase assay using a benchtop orbitrap mass spectrometer to investigate the effect of kinase inhibitors on kinase signaling pathways.
Academic Article Acetylation-dependent regulation of Skp2 function.
Concept Amino Acid Sequence
Academic Article Correlation profiling for determining kinase-substrate relationships.
Academic Article Intramolecular interactions control Vms1 translocation to damaged mitochondria.
Academic Article Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
Academic Article The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2.
Academic Article Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development.
Academic Article Lysine 63-linked polyubiquitination is required for EGF receptor degradation.
Academic Article TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.
Academic Article PP2ARts1 is a master regulator of pathways that control cell size.
Academic Article Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin.
Academic Article SUMOylation of Psmd1 controls Adrm1 interaction with the proteasome.
Academic Article Extended ubiquitin species are protein-based DUB inhibitors.
Academic Article Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.
Academic Article UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway.
Academic Article Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics.
Academic Article An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis.
Academic Article A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides.
Academic Article The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.
Academic Article Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.
Academic Article Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine.
Academic Article Proteomics of Primary Cilia by Proximity Labeling.
Academic Article A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.
Academic Article PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
Academic Article LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.
Academic Article Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.
Academic Article Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.
Academic Article Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.
Academic Article Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage.
Academic Article Evaluating False Transfer Rates from the Match-between-Runs Algorithm with a Two-Proteome Model.
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  • Amino Acid Sequence
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.