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Item TypeName
Academic Article Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys.
Academic Article Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
Academic Article BK virus-associated hemorrhagic cystitis in a Human Immunodeficiency Virus-infected patient.
Academic Article Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex.
Academic Article Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys.
Academic Article Viral evolution and challenges in the development of HIV vaccines.
Academic Article Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
Academic Article Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination.
Academic Article Prospects for vaccine protection against HIV-1 infection and AIDS.
Academic Article Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
Academic Article DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate.
Academic Article Adenovirus vector-based vaccines for human immunodeficiency virus type 1.
Academic Article Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines.
Academic Article Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
Academic Article Cytokine-induced augmentation of DNA vaccine-elicited SIV-specific immunity in rhesus monkeys.
Academic Article Novel adenovirus vector-based vaccines for HIV-1.
Academic Article Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.
Academic Article Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses.
Academic Article Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates.
Academic Article Differential antigen requirements for protection against systemic and intranasal vaccinia virus challenges in mice.
Academic Article Adenovirus serotype 5 hexon mediates liver gene transfer.
Academic Article Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity.
Academic Article Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following simian immunodeficiency virus challenges of vaccinated rhesus monkeys.
Academic Article Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys.
Academic Article Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys.
Academic Article Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs.
Academic Article DNA vaccination for HIV-1 and SIV.
Academic Article CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses.
Academic Article Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys.
Academic Article Use of molecular beacons for rapid, real-time, quantitative monitoring of cytotoxic T-lymphocyte epitope mutations in simian immunodeficiency virus.
Academic Article Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.
Academic Article Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6 cells.
Academic Article Comparison of multiple vaccine vectors in a single heterologous prime-boost trial.
Academic Article Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination.
Academic Article Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys.
Academic Article Fitness costs limit viral escape from cytotoxic T lymphocytes at a structurally constrained epitope.
Academic Article An IL-2/Ig fusion protein influences CD4+ T lymphocytes in naive and simian immunodeficiency virus-infected Rhesus monkeys.
Academic Article Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys.
Academic Article Magnitude and diversity of cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys.
Academic Article Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta).
Academic Article Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity.
Academic Article Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination.
Academic Article TLR4 ligands augment antigen-specific CD8+ T lymphocyte responses elicited by a viral vaccine vector.
Academic Article Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.
Academic Article A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates.
Academic Article Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys.
Academic Article Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome.
Academic Article Focus and breadth of cellular immune responses elicited by a heterologous insert prime-boost vaccine regimen in rhesus monkeys.
Academic Article Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys.
Academic Article Modulation of DNA vaccine-elicited CD8+ T-lymphocyte epitope immunodominance hierarchies.
Academic Article Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys.
Academic Article Structural constraints on viral escape from HIV- and SIV-specific cytotoxic T-lymphocytes.
Academic Article Generation of a novel replication-incompetent adenoviral vector derived from human adenovirus type 49: manufacture on PER.C6 cells, tropism and immunogenicity.
Academic Article Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.
Academic Article Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys.
Academic Article Durable mucosal simian immunodeficiency virus-specific effector memory T lymphocyte responses elicited by recombinant adenovirus vectors in rhesus monkeys.
Academic Article An attenuated Listeria monocytogenes vector primes more potent simian immunodeficiency virus-specific mucosal immunity than DNA vaccines in mice.
Academic Article Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys.
Academic Article HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120.
Academic Article Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
Academic Article Rational design of gene-based vaccines.
Academic Article Interactions among the major and minor coat proteins of polyomavirus.
Academic Article Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys.
Academic Article B7 co-stimulatory requirements differ for induction of immune responses by DNA, protein and recombinant pox virus vaccination.
Academic Article Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies.
Academic Article Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines.
Academic Article A mAb against HLA-A2 can be influenced both positively and negatively by the associated peptide.
Academic Article Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation.
Academic Article Bovine adenovirus vectored vaccine for avian influenza.
Academic Article Immunogenicity of recombinant fiber-chimeric adenovirus serotype 35 vector-based vaccines in mice and rhesus monkeys.
Academic Article Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.
Academic Article Comparative analysis of simian immunodeficiency virus gag-specific effector and memory CD8+ T cells induced by different adenovirus vectors.
Concept Simian virus 40
Concept nef Gene Products, Human Immunodeficiency Virus
Concept Virus Internalization
Concept Virus Activation
Concept env Gene Products, Human Immunodeficiency Virus
Concept Canarypox virus
Concept Virus Latency
Concept Fowlpox virus
Concept Ectromelia virus
Concept Human T-lymphotropic virus 1
Concept RNA Virus Infections
Concept Lymphocytic choriomeningitis virus
Concept Cowpox virus
Concept BK Virus
Concept Human Immunodeficiency Virus Proteins
Concept Influenza A Virus, H5N1 Subtype
Concept Vaccinia virus
Concept pol Gene Products, Human Immunodeficiency Virus
Concept Virus Cultivation
Concept Measles virus
Concept Encephalitis Virus, Venezuelan Equine
Concept Herpesvirus 4, Human
Concept Tumor Virus Infections
Concept Dengue Virus
Concept SARS Virus
Concept Influenza A virus
Concept Herpesvirus 8, Human
Concept Virus Diseases
Concept gag Gene Products, Human Immunodeficiency Virus
Concept Simian immunodeficiency virus
Concept Vaccines, Virus-Like Particle
Concept Receptors, Virus
Concept Virus Replication
Academic Article Nonreplicating vectors in HIV vaccines.
Academic Article Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination.
Academic Article Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys.
Academic Article Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Academic Article The quest for an HIV-1 vaccine--moving forward.
Academic Article GagPol-specific CD4? T-cells increase the antibody response to Env by intrastructural help.
Academic Article The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys.
Academic Article Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.
Academic Article Adenovirus serotype 26 and 35 vectors induce simian immunodeficiency virus-specific T lymphocyte responses in foreskin in rhesus monkeys.
Academic Article Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer.
Academic Article Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies.
Academic Article First-in-human evaluation of a hexon chimeric adenovirus vector expressing HIV-1 Env (IPCAVD 002).
Academic Article Immunologic strategies for HIV-1 remission and eradication.
Academic Article Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys.
Academic Article Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer.
Academic Article Induction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humans.
Academic Article Novel vaccine vectors for HIV-1.
Academic Article Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks.
Academic Article Design of lipid nanocapsule delivery vehicles for multivalent display of recombinant Env trimers in HIV vaccination.
Academic Article Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.
Academic Article A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component.
Academic Article Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys.
Academic Article CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells.
Academic Article Antigen-specific NK cell memory in rhesus macaques.
Academic Article Attenuation of Replication-Competent Adenovirus Serotype 26 Vaccines by Vectorization.
Academic Article Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences.
Academic Article Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial.
Academic Article SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.
Academic Article Transient CD4+ T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses.
Academic Article Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys.
Academic Article Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques.
Academic Article Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy.
Academic Article Novel immunological strategies for HIV-1 eradication.
Academic Article Vaccine protection against Zika virus from Brazil.
Grant Consortia for Innovative AIDS Research in Nonhuman Primates
Grant Augmentation of DNA Vaccine-Elicited Immunity to HIV/SIV
Grant Novel Heterologous Adenovirus Prime-Boost HIV-1 Vaccine
Grant Consortium for AIDS Vaccine Research in Nonhuman Primates
Academic Article Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys.
Academic Article Inhibitory receptor expression on memory CD8 T cells following Ad vector immunization.
Academic Article Rapid development of a DNA vaccine for Zika virus.
Academic Article Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus.
Academic Article Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys.
Academic Article Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens.
Academic Article VirusSeeker, a computational pipeline for virus discovery and virome composition analysis.
Academic Article Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals.
Academic Article Prospects for a Zika Virus Vaccine.
Academic Article Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles.
Academic Article Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.
Academic Article Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection.
Academic Article Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys.
Academic Article Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys.
Academic Article Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.
Academic Article Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys.
Academic Article Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys.
Academic Article Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques.
Academic Article Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge.
Grant Optimization of Broadly Neutralizing Antibodies for HIV Eradication
Academic Article Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.
Academic Article HIV-1 Latency by Transition.
Academic Article Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Academic Article Durability and correlates of vaccine protection against Zika virus in rhesus monkeys.
Academic Article Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials.
Academic Article Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection.
Academic Article Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.
Academic Article Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV.
Academic Article Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.
Academic Article Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys.
Academic Article First-in-Human Randomized, Controlled Trial of Mosaic HIV-1 Immunogens Delivered via a Modified Vaccinia Ankara Vector.
Academic Article Neutralizing Antibody Responses following Long-Term Vaccination with HIV-1 Env gp140 in Guinea Pigs.
Academic Article Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys.
Academic Article Zika virus vaccines.
Academic Article Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors.
Academic Article Immune Correlate-Guided HIV Vaccine Design.
Academic Article T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection.
Academic Article Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge.
Academic Article Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys.
Academic Article First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1.
Academic Article CMV Primes Functional Alternative Signaling in Adaptive ?g NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.
Academic Article Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy.
Academic Article Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.
Academic Article HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design.
Academic Article HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge.
Academic Article Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
Academic Article The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections.
Academic Article A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.
Academic Article Lack of therapeutic efficacy of an antibody to a4ß7 in SIVmac251-infected rhesus macaques.
Academic Article A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge.
Academic Article Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-aßR-/- Mice.
Academic Article Assessment of Immunogenicity and Efficacy of a Zika Vaccine Using Modified Vaccinia Ankara Virus as Carriers.
Academic Article Evolution of the innate and adaptive immune response in women with acute Zika virus infection.
Academic Article NS1 DNA vaccination protects against Zika infection through T cell-mediated immunity in immunocompetent mice.
Academic Article Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor.
Academic Article Comparison of shortened mosaic HIV-1 vaccine schedules: a randomised, double-blind, placebo-controlled phase 1 trial (IPCAVD010/HPX1002) and a preclinical study in rhesus monkeys (NHP 17-22).
Academic Article Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C.
Academic Article Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections.
Academic Article SARS-CoV-2 infection protects against rechallenge in rhesus macaques.
Academic Article Sustained maternal antibody and cellular immune responses in pregnant women infected with Zika virus and mother to infant transfer of Zika-specific antibodies.
Academic Article Immunogenicity and Efficacy of Zika Virus Envelope Domain III in DNA, Protein, and ChAdOx1 Adenoviral-Vectored Vaccines.
Academic Article Safety and immunogenicity of a Zika purified inactivated virus vaccine given via standard, accelerated, or shortened schedules: a single-centre, double-blind, sequential-group, randomised, placebo-controlled, phase 1 trial.
Academic Article Potently neutralizing and protective human antibodies against SARS-CoV-2.
Academic Article Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.
Academic Article Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics.
Academic Article Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.
Academic Article Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques.
Academic Article Models of SIV rebound after treatment interruption that involve multiple reactivation events.
Academic Article Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation.
Academic Article Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation.
Academic Article Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic.
Academic Article Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference.
Academic Article A Double-Blind, Randomized, Placebo-Controlled Phase 1 Study of Ad26.ZIKV.001, an Ad26-Vectored Anti-Zika Virus Vaccine.
Academic Article TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption.
Academic Article Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques.
Academic Article Co-infection with coronavirus disease 2019, previously undiagnosed human immunodeficiency virus, Pneumocystis jirovecii pneumonia and cytomegalovirus pneumonitis, with possible immune reconstitution inflammatory syndrome.
Academic Article Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques.
Academic Article Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice.
Academic Article Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.
Grant I4C 2.0: Immunotherapy for Cure
Academic Article SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques.
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  • Herpesvirus 4 Human
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.