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Item TypeName
Academic Article Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys.
Academic Article Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
Academic Article BK virus-associated hemorrhagic cystitis in a Human Immunodeficiency Virus-infected patient.
Academic Article Challenges in the search for an HIV vaccine.
Academic Article Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys.
Academic Article Viral evolution and challenges in the development of HIV vaccines.
Academic Article Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
Academic Article Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination.
Academic Article Prospects for vaccine protection against HIV-1 infection and AIDS.
Academic Article Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
Academic Article Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses.
Academic Article Adenovirus vector-based vaccines for human immunodeficiency virus type 1.
Academic Article Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines.
Academic Article Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
Academic Article Cytokine-induced augmentation of DNA vaccine-elicited SIV-specific immunity in rhesus monkeys.
Academic Article Novel adenovirus vector-based vaccines for HIV-1.
Academic Article Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates.
Academic Article HIV vaccine trial canceled.
Academic Article Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following simian immunodeficiency virus challenges of vaccinated rhesus monkeys.
Academic Article Timing of plasmid cytokine (IL-2/Ig) administration affects HIV-1 vaccine immunogenicity in HIV-seronegative subjects.
Academic Article Accelerated heterologous adenovirus prime-boost SIV vaccine in neonatal rhesus monkeys.
Academic Article Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys.
Academic Article Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans.
Academic Article International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations.
Academic Article HIV-1 vaccine candidate ineffective.
Academic Article Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs.
Academic Article DNA vaccination for HIV-1 and SIV.
Academic Article Use of molecular beacons for rapid, real-time, quantitative monitoring of cytotoxic T-lymphocyte epitope mutations in simian immunodeficiency virus.
Academic Article Translational Mini-Review Series on Vaccines for HIV: T lymphocyte trafficking and vaccine-elicited mucosal immunity.
Academic Article Potent CD4+ T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF.
Academic Article Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity.
Academic Article Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.
Academic Article Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection.
Academic Article Power to detect the effects of HIV vaccination in repeated low-dose challenge experiments.
Academic Article An IL-2/Ig fusion protein influences CD4+ T lymphocytes in naive and simian immunodeficiency virus-infected Rhesus monkeys.
Academic Article Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys.
Academic Article Magnitude and diversity of cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys.
Academic Article Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta).
Academic Article Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination.
Academic Article Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.
Academic Article Mucosal trafficking of vector-specific CD4+ T lymphocytes following vaccination of rhesus monkeys with adenovirus serotype 5.
Academic Article A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates.
Academic Article Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys.
Academic Article Translational Mini-Review Series on Vaccines for HIV: Harnessing innate immunity for HIV vaccine development.
Academic Article HIV-1 vaccine development after STEP.
Academic Article Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome.
Academic Article Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors.
Academic Article Focus and breadth of cellular immune responses elicited by a heterologous insert prime-boost vaccine regimen in rhesus monkeys.
Academic Article Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells.
Academic Article Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys.
Academic Article HIV escape from cytotoxic T lymphocytes: a potential hurdle for vaccines?
Academic Article Structural constraints on viral escape from HIV- and SIV-specific cytotoxic T-lymphocytes.
Academic Article Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.
Academic Article Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys.
Academic Article Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys.
Academic Article A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys.
Academic Article Characterization of humoral and cellular immune responses elicited by a recombinant adenovirus serotype 26 HIV-1 Env vaccine in healthy adults (IPCAVD 001).
Academic Article First-in-human evaluation of the safety and immunogenicity of a recombinant adenovirus serotype 26 HIV-1 Env vaccine (IPCAVD 001).
Academic Article Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
Academic Article Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration.
Academic Article Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys.
Academic Article B7 co-stimulatory requirements differ for induction of immune responses by DNA, protein and recombinant pox virus vaccination.
Academic Article Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies.
Academic Article Challenges in the development of an HIV-1 vaccine.
Academic Article Route of adenovirus-based HIV-1 vaccine delivery impacts the phenotype and trafficking of vaccine-elicited CD8+ T lymphocytes.
Academic Article A Blueprint for HIV Vaccine Discovery.
Academic Article Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.
Concept AIDS Vaccines
Concept Simian Acquired Immunodeficiency Syndrome
Concept Acquired Immunodeficiency Syndrome
Concept AIDS Serodiagnosis
Concept AIDS-Related Opportunistic Infections
Academic Article A global approach to HIV-1 vaccine development.
Academic Article Nonreplicating vectors in HIV vaccines.
Academic Article Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys.
Academic Article Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Academic Article The quest for an HIV-1 vaccine--moving forward.
Academic Article The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys.
Academic Article First-in-human evaluation of a hexon chimeric adenovirus vector expressing HIV-1 Env (IPCAVD 002).
Academic Article Immunologic strategies for HIV-1 remission and eradication.
Academic Article Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys.
Academic Article SIV- and Vaccine-elicited NK Cell Memory in Rhesus Macaques.
Academic Article Common features of mucosal and peripheral antibody responses elicited by candidate HIV-1 vaccines in rhesus monkeys.
Academic Article Plasmablast Phenotype and Mucosal Antibodies to V2 in Vaccine-induced Protection Against SIVmac251.
Academic Article The immune space: a concept and template for rationalizing vaccine development.
Academic Article Induction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humans.
Academic Article Novel vaccine vectors for HIV-1.
Academic Article Accelerating HIV-1 Vaccine Efficacy Trials.
Academic Article Quantification of the epitope diversity of HIV-1-specific binding antibodies by peptide microarrays for global HIV-1 vaccine development.
Academic Article A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component.
Academic Article Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys.
Academic Article Antigen-specific NK cell memory in rhesus macaques.
Academic Article Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.
Academic Article Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences.
Academic Article Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention: A Randomized Trial.
Academic Article Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial.
Academic Article Broadly Neutralizing Antibodies for HIV Eradication.
Academic Article SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.
Academic Article Transient CD4+ T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses.
Academic Article Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys.
Academic Article Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques.
Academic Article International AIDS Society global scientific strategy: towards an HIV cure 2016.
Academic Article New concepts in HIV-1 vaccine development.
Grant METAGENOMICS OF ENTERIC DISEASE IN SIV-INFECTED AND UNINFECTED MACAQUES
Grant Consortia for Innovative AIDS Research in Nonhuman Primates
Grant New England Primate Research Center Base Grant
Grant Cytokine-Augmented DNA Vaccine-Elicited Immunity to HIV
Grant METAGENOMICS OF ENTERIC DISEASE IN SIV-INFECTED AND UNINFECTED MACAQUES
Grant Consortium for AIDS Vaccine Research in Nonhuman Primates
Grant Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery
Academic Article Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus.
Academic Article Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys.
Academic Article Systems serology for evaluation of HIV vaccine trials.
Academic Article Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles.
Academic Article Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys.
Academic Article Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.
Academic Article Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys.
Academic Article Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys.
Academic Article Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge.
Academic Article Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.
Academic Article Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.
Academic Article Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.
Academic Article Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV.
Academic Article First-in-Human Randomized, Controlled Trial of Mosaic HIV-1 Immunogens Delivered via a Modified Vaccinia Ankara Vector.
Academic Article Neutralizing Antibody Responses following Long-Term Vaccination with HIV-1 Env gp140 in Guinea Pigs.
Academic Article A step forward for HIV vaccines.
Academic Article Immune Correlate-Guided HIV Vaccine Design.
Academic Article T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection.
Academic Article Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19).
Academic Article Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys.
Academic Article First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1.
Academic Article CMV Primes Functional Alternative Signaling in Adaptive ?g NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.
Academic Article Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy.
Academic Article Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.
Academic Article HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge.
Academic Article Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
Academic Article Neutralizing antibodies for HIV-1 prevention.
Academic Article The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections.
Academic Article A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.
Academic Article Lack of therapeutic efficacy of an antibody to a4ß7 in SIVmac251-infected rhesus macaques.
Academic Article A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge.
Academic Article Comparison of shortened mosaic HIV-1 vaccine schedules: a randomised, double-blind, placebo-controlled phase 1 trial (IPCAVD010/HPX1002) and a preclinical study in rhesus monkeys (NHP 17-22).
Academic Article Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C.
Academic Article Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption.
Academic Article Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.
Academic Article Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques.
Academic Article Models of SIV rebound after treatment interruption that involve multiple reactivation events.
Academic Article Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study.
Academic Article Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation.
Academic Article Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation.
Academic Article Adenovirus-vectored vaccine containing multidimensionally conserved parts of the HIV proteome is immunogenic in rhesus macaques.
Academic Article TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption.
Academic Article Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques.
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  • Acquired Immunodeficiency Syndrome
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.