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Skin inflammation in RelB(-/-) mice leads to defective immunity and impaired clearance of vaccinia virus.
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation.
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.
IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum.