Harvard Catalyst Profiles

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One or more keywords matched the following items that are connected to Brown, Jennifer
Item TypeName
Academic Article Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
Academic Article BCL2 suppresses PARP1 function and nonapoptotic cell death.
Concept Proto-Oncogene Proteins c-bcl-2
Concept Proto-Oncogene Proteins c-bcl-6
Academic Article Novel agents for the treatment of chronic lymphocytic leukemia.
Academic Article Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition.
Academic Article Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease.
Academic Article Novel treatments for chronic lymphocytic leukemia and moving forward.
Academic Article The rosy future of BCL-2 inhibition in chronic lymphocytic leukemia: pursuit of a worthy target.
Academic Article Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia.
Academic Article Chemoimmunotherapy Versus Targeted Treatment in Chronic Lymphocytic Leukemia: When, How Long, How Much, and in Which Combination?
Academic Article The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.
Academic Article Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells.
Academic Article Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation.
Academic Article The potential combination of BCL-2 inhibitors and ibrutinib as frontline therapy in chronic lymphocytic leukemia.
Academic Article Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.
Academic Article Changes in Bcl-2 members after ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL.
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  • Proto Oncogene Proteins c bcl 6
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.